Summary: MgrB protein
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The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive promoter . Deletion of mgrB results in a potent increase in PhoP-regulated transcription . The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.
Kato A, Tanabe H, Utsumi R;, J Bacteriol. 1999;181:5516-5520.: Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters. PUBMED:10464230 EPMC:10464230
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This tab holds annotation information from the InterPro database.
InterPro entry IPR020907
This entry represents MgrB, a short lipoprotein that is induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system [PUBMED:10464230]. Deletion of MgrB results in a potent increase in PhoP-regulated transcription [PUBMED:20041203].
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Curation and family details
|Number in seed:||9|
|Number in full:||2051|
|Average length of the domain:||29.00 aa|
|Average identity of full alignment:||91 %|
|Average coverage of the sequence by the domain:||62.51 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
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