Summary: Centrosome localisation domain of Cep57
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Centrosome localisation domain of Cep57 Provide feedback
The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, PF06657 is the microtubule-binding region of Cep57.
Momotani K, Khromov AS, Miyake T, Stukenberg PT, Somlyo AV;, Biochem J. 2008;412:265-273.: Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. PUBMED:18294141 EPMC:18294141
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025913
The CLD or centrosome localisation domain of Cep57 is found at the N terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component [PUBMED:18294141]. This N-terminal region can also multimerise with the N terminus of other Cep57 molecules.
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|Molecular function||gamma-tubulin binding (GO:0043015)|
|identical protein binding (GO:0042802)|
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Curation and family details
|Number in seed:||8|
|Number in full:||162|
|Average length of the domain:||161.50 aa|
|Average identity of full alignment:||53 %|
|Average coverage of the sequence by the domain:||39.03 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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