Summary: Ubinuclein conserved middle domain
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Ubinuclein conserved middle domain Provide feedback
Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF)  . The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.
Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD;, Mol Cell Biol. 2009;29:758-70.: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. PUBMED:19029251 EPMC:19029251
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Curation and family details
|Seed source:||Joint Center of Structural Genomics (JCSG)|
|Number in seed:||12|
|Number in full:||163|
|Average length of the domain:||196.10 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||21.34 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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