Summary: Alternative WD40 repeat motif
Alternative WD40 repeat motif Provide feedback
WD repeats are short subdomains of about 40 amino acids and fold into 4 antiparallel beta hairpins. This domain here has been detected on the C-terminus of WD repeat-containing protein 18 during target selection by the Joint Center for Structural Genomics.
Internal database links
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR026987
WD repeats are short subdomains of about 40 amino acids and fold into 4 anti-parallel beta hairpins. The domain represented by this entry has been detected on the C terminus of WD repeat-containing protein 18 (Wdr18), which palys a role during development [PUBMED:21876750].
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Joint Center of Structural Genomics (JCSG)|
|Number in seed:||9|
|Number in full:||68|
|Average length of the domain:||47.40 aa|
|Average identity of full alignment:||63 %|
|Average coverage of the sequence by the domain:||11.14 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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