Summary: CAAD domains of cyanobacterial aminoacyl-tRNA synthetase
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CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Provide feedback
This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids . aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.
Luque I, Riera-Alberola ML, Andujar A, Ochoa de Alda JA;, Mol Biol Evol. 2008;25:2369-2389.: Intraphylum diversity and complex evolution of cyanobacterial aminoacyl-tRNA synthetases. PUBMED:18775898 EPMC:18775898
Olmedo-Verd E, Santamaria-Gomez J, Ochoa de Alda JA, Ribas de Pouplana L, Luque I;, J Biol Chem. 2011;286:41057-41068.: Membrane anchoring of aminoacyl-tRNA synthetases by convergent acquisition of a novel protein domain. PUBMED:21965654 EPMC:21965654
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025564
This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids [PUBMED:18775898]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.
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Curation and family details
|Number in seed:||124|
|Number in full:||551|
|Average length of the domain:||82.50 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||35.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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