Summary: ComG operon protein 7
ComG operon protein 7 Provide feedback
This family is required for DNA-binding during transformation of competent bacterial cells .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR020372
This entry represents comG operon protein 7, ComGG. It is required for DNA-binding during transformation of competent bacterial cells [PUBMED:9422590]. About half of pre-ComGG is present as a peripheral membrane protein and the other half as an integral protein. Upon partial processing, ComGG is translocated to a position outside the membrane [PUBMED:9723928].
ComK activates transcription at the comG promoter by stabilising the binding of RNA polymerase to the comG promoter [PUBMED:14762007]. The comG operon of B. subtilis encodes seven membrane associated proteins which function in binding of transforming DNA to the competent cell surface [PUBMED:9723928]. ComGC, GD, GE and GG have N-terminal sequence motifs typical of type 4 pre-pilins and are processed by a pathway that requires the product of comC, also an essential competence gene. When strains missing each of the 7 proteins are created, they were all found to be nontransformable and failed to bind transforming DNA to the cell surface [PUBMED:9422590]. Another gene, comZ (yjzA) positively affects the expression of comG but does not affect the expression of comK and the other three late competence operons [PUBMED:10940045].
Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. Cells that take up DNA inevitably acquire the nucleotides the DNA consists of, and, because nucleotides are needed for DNA and RNA synthesis and are expensive to synthesise, these may make a significant contribution to the cell's energy budget [PUBMED:11483988]. The lateral gene transfer caused by competence also contributes to the genetic diversity that makes evolution possible.
DNA usually becomes available by the death and lysis of other cells. Competent bacteria use components of extracellular filaments called type 4 pili to create pores in their membranes and pull DNA through the pores into the cytoplasm. This process, including the development of competence and the expression of the uptake machinery, is regulated in response to cell-cell signalling and/or nutritional conditions [PUBMED:8901420].
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Curation and family details
|Number in seed:||18|
|Number in full:||125|
|Average length of the domain:||94.30 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||78.36 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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