Summary: Phage phiEco32-like COOH.NH2 ligase-type 2
Phage phiEco32-like COOH.NH2 ligase-type 2 Provide feedback
A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis .
Iyer LM, Abhiman S, Maxwell Burroughs A, Aravind L;, Mol Biosyst. 2009;5:1636-1660.: Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins. PUBMED:20023723 EPMC:20023723
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025681
This entry represents a family of COOH-NH2 ligases/GCS superfamily found in the neighbourhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis [PUBMED:20023723].
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a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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This clan represents a superfamily of carboxylate-amine/ammonia ligases  that includes Gamma-Glutamylcysteine synthetase (gamma-GCS) and glutamine synthetase (GS). Gamma-Glutamylcysteine synthetase (gamma-GCS) catalyses the first step in the de novo biosynthesis of glutathione.
The clan contains the following 9 members:Amidoligase_2 ATP-gua_Ptrans COOH-NH2_lig DUF2126 GCS GCS2 Gln-synt_C Glu_cys_ligase Pup_ligase
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Author:||Iyer LM, Abhiman S, Burroughs AM, Aravind L|
|Number in seed:||8|
|Number in full:||44|
|Average length of the domain:||234.20 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||50.04 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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