Summary: A nuclease of the HNH/ENDO VII superfamily with conserved WHH
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A nuclease of the HNH/ENDO VII superfamily with conserved WHH Provide feedback
WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems  and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis .
Zhang D, Iyer LM, Aravind L;, Nucleic Acids Res. 2011;39:4532-4552.: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. PUBMED:21306995 EPMC:21306995
Internal database links
|Similarity to PfamA using HHSearch:||Colicin-DNase|
This tab holds annotation information from the InterPro database.
InterPro entry IPR032869
WHH domain containing protein is a predicted nuclease of the HNH/ENDO VII superfamily. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems [PUBMED:21306995] and functions as a toxin module. It is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis [PUBMED:21306995].
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This superfamily defined originally by SCOP contains a diverse range of endonucleases. Later Grishin identified the MH1 domain as belonging to the superfamily .
The clan contains the following 23 members:AHH Colicin-DNase DFF40 DUF1524 DUF968 Endonuclea_NS_2 Endonuclease_1 Endonuclease_7 Endonuclease_NS GH-E HNH HNH_2 HNH_3 HNH_4 HNH_5 HNHc_6 ICEA LHH MH1 NinG RecA_dep_nuc WHH zf-His_Me_endon
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Curation and family details
|Author:||Zhang D, Iyer LM, Aravind L;|
|Number in seed:||30|
|Number in full:||212|
|Average length of the domain:||43.60 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||9.46 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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