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57  structures 6763  species 0  interactions 35622  sequences 5603  architectures

Family: TPR_19 (PF14559)

Summary: Tetratricopeptide repeat

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Tetratricopeptide repeat Provide feedback

No Pfam abstract.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(146)
Full
(35622)
Representative proteomes UniProt
(157130)
RP15
(5982)
RP35
(17527)
RP55
(33693)
RP75
(54062)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(146)
Full
(35622)
Representative proteomes UniProt
(157130)
RP15
(5982)
RP35
(17527)
RP55
(33693)
RP75
(54062)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(146)
Full
(35622)
Representative proteomes UniProt
(157130)
RP15
(5982)
RP35
(17527)
RP55
(33693)
RP75
(54062)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q87RI8
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Eberhardt R
Number in seed: 146
Number in full: 35622
Average length of the domain: 65.20 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 13.77 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.0 25.0
Noise cut-off 24.9 24.9
Model length: 68
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TPR_19 domain has been found. There are 57 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096MJ38 View 3D Structure Click here
A0A0P0VEB0 View 3D Structure Click here
A0A0P0XBC4 View 3D Structure Click here
A0A0R4IWM4 View 3D Structure Click here
A0A1D6DZE5 View 3D Structure Click here
A0A1D6FLB1 View 3D Structure Click here
A0A1D6KJP4 View 3D Structure Click here
A0A1D6LEY9 View 3D Structure Click here
A0A1D6N6Y3 View 3D Structure Click here
A0A1D6NJK2 View 3D Structure Click here
A0A1D8PQM5 View 3D Structure Click here
A0A2R8PWG5 View 3D Structure Click here
A0A2R8PYN3 View 3D Structure Click here
A0A368UGZ5 View 3D Structure Click here
A0A368UGZ5 View 3D Structure Click here
A1A5S1 View 3D Structure Click here
A1Z8E9 View 3D Structure Click here
A3KDM3 View 3D Structure Click here
A3KDM3 View 3D Structure Click here
A3QK11 View 3D Structure Click here
A4HS50 View 3D Structure Click here
A4HYI1 View 3D Structure Click here
A4I2R4 View 3D Structure Click here
A4IBU6 View 3D Structure Click here
B0BNG0 View 3D Structure Click here
B0BNG0 View 3D Structure Click here
B0R0W1 View 3D Structure Click here
B3DJA9 View 3D Structure Click here
B3DJF2 View 3D Structure Click here
B4FDG5 View 3D Structure Click here
B6SLI0 View 3D Structure Click here
B6SSY1 View 3D Structure Click here
C4J723 View 3D Structure Click here
D3ZE49 View 3D Structure Click here
D3ZZJ4 View 3D Structure Click here
D4A2M3 View 3D Structure Click here
E7F507 View 3D Structure Click here
E9PV48 View 3D Structure Click here
F6ZE64 View 3D Structure Click here
G3V897 View 3D Structure Click here
I1K480 View 3D Structure Click here
I1KBC8 View 3D Structure Click here
I1KC83 View 3D Structure Click here
I1KSN5 View 3D Structure Click here
I1KU07 View 3D Structure Click here
I1KU07 View 3D Structure Click here
I1L1N9 View 3D Structure Click here
I1LWZ1 View 3D Structure Click here
I1M3M3 View 3D Structure Click here
I1M5T8 View 3D Structure Click here
I1M5T8 View 3D Structure Click here
I1MHE8 View 3D Structure Click here
I1MJA0 View 3D Structure Click here
I1N4V8 View 3D Structure Click here
I1N6L5 View 3D Structure Click here
K7KL29 View 3D Structure Click here
K7KLL1 View 3D Structure Click here
K7KZD4 View 3D Structure Click here
K7VJP9 View 3D Structure Click here
O13754 View 3D Structure Click here
P25638 View 3D Structure Click here
P37650 View 3D Structure Click here
P38825 View 3D Structure Click here
P66948 View 3D Structure Click here
P77395 View 3D Structure Click here
Q10NP2 View 3D Structure Click here
Q15006 View 3D Structure Click here
Q15006 View 3D Structure Click here
Q2G042 View 3D Structure Click here
Q337L2 View 3D Structure Click here
Q3UV71 View 3D Structure Click here
Q4CQ55 View 3D Structure Click here
Q4CYP7 View 3D Structure Click here
Q4D1B0 View 3D Structure Click here
Q4D5B0 View 3D Structure Click here
Q4D661 View 3D Structure Click here
Q4D7D9 View 3D Structure Click here
Q4DQE3 View 3D Structure Click here
Q4DR66 View 3D Structure Click here
Q4DSP8 View 3D Structure Click here
Q4E3Y7 View 3D Structure Click here
Q4E652 View 3D Structure Click here
Q54J83 View 3D Structure Click here
Q54M21 View 3D Structure Click here
Q54Y92 View 3D Structure Click here
Q54Y92 View 3D Structure Click here
Q55CE4 View 3D Structure Click here
Q5APB7 View 3D Structure Click here
Q5N719 View 3D Structure Click here
Q5N7T3 View 3D Structure Click here
Q64112 View 3D Structure Click here
Q64345 View 3D Structure Click here
Q65XE1 View 3D Structure Click here
Q66GN3 View 3D Structure Click here
Q6AYE7 View 3D Structure Click here
Q6P0U6 View 3D Structure Click here
Q6P0U6 View 3D Structure Click here
Q6TGY8 View 3D Structure Click here
Q6Z0Z6 View 3D Structure Click here
Q6Z6E3 View 3D Structure Click here
Q7K0X3 View 3D Structure Click here
Q7K0X3 View 3D Structure Click here
Q7K7W5 View 3D Structure Click here
Q86WT1 View 3D Structure Click here
Q8C0S4 View 3D Structure Click here
Q8GUP0 View 3D Structure Click here
Q8IUR5 View 3D Structure Click here
Q8K2L8 View 3D Structure Click here
Q8LGU6 View 3D Structure Click here
Q8N5M4 View 3D Structure Click here
Q8VY89 View 3D Structure Click here
Q8WVT3 View 3D Structure Click here
Q91YR7 View 3D Structure Click here
Q93YR3 View 3D Structure Click here
Q94A56 View 3D Structure Click here
Q9LS48 View 3D Structure Click here
Q9R0T3 View 3D Structure Click here
Q9SD20 View 3D Structure Click here