# STOCKHOLM 1.0
#=GF ID   NrfD_2
#=GF AC   PF14589.1
#=GF DE   Polysulfide reductase
#=GF AU   Coggill P
#=GF SE   CATH:2vpzC00, Pfam-B_200168
#=GF GA   27.00 27.00;
#=GF TC   28.90 28.60;
#=GF NC   26.60 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18536726
#=GF RT   Molecular mechanism of energy conservation in polysulfide
#=GF RT   respiration.
#=GF RA   Jormakka M, Yokoyama K, Yano T, Tamakoshi M, Akimoto S,
#=GF RA   Shimamura T, Curmi P, Iwata S;
#=GF RL   Nat Struct Mol Biol. 2008;15:730-737.
#=GF CC   Bacterial polysulfide reductase is an integral membrane protein
#=GF CC   complex responsible for quinone-coupled reduction of
#=GF CC   polysulfide, a process important in extreme environments such as
#=GF CC   deep-sea vents and hot springs. Polysulfides are a class of
#=GF CC   compounds composed of chains of sulfur atoms, which in their
#=GF CC   simplest form are present as an anion with general formula
#=GF CC   Sn(2-). In nature, polysulfides are found in particularly high
#=GF CC   concentrations in extreme volcanic or geothermically active
#=GF CC   environments. Here, the reduction and oxidation of polysulfides
#=GF CC   are vital processes for many bacteria and are essential steps in
#=GF CC   the global sulfur cycle. In particular, the reduction of
#=GF CC   polysulfide to hydrogen sulfide in these environments is usually
#=GF CC   linked to energy-generating respiratory processes, supporting
#=GF CC   growth of many microorganisms, particularly hyperthermophiles.
#=GF SQ   3
#=GS E8PMP4_THESS/2-252  AC E8PMP4.1
#=GS E4U7K8_OCEP5/2-264  AC E4U7K8.1
#=GS Q72LA6_THET2/2-252  AC Q72LA6.1
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPZ G; 1-251;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPZ C; 2-252;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPW G; 1-251;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPY G; 1-251;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPY C; 2-252;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPW C; 2-252;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPX G; 1-251;
#=GS Q72LA6_THET2/2-252  DR PDB; 2VPX C; 2-252;
E8PMP4_THESS/2-252             TEFYGLPNAGEFWHWTNLLHFILVGLAGGMAFLTALLHLKGHPEARRYTLWALGLIALDLFVLWAESPARFRFTHVWLFLSFHPTSPIWWGSWGLALSFVSAGLLYLGKGPSKPLAWGLLAFSLVALAYPGMALAVNLNRPLWNALLAGLFPLTALVLGLGVAVLMKSSWALYP.LRILLGASLFLAFLYPFTLT...LEAR..GHLWEEGGVLYGLFLALG....LGAFGKESLAPWAAFLAAAG...LRALLVAVGQWQGL..G
E4U7K8_OCEP5/2-264             TTFYGLPGAEAFWHWTTLVHFLLVALAGGTAFYTAVLGIRRAASARGLAWLALAFIVLDLFMLWAESPARFRFSHVWLFLSFEPASAIWWGAWGLATSALMLLLLALGLGPARFWAGVLALTSAVVLAYPGYALAANAARPLWDHLLLAFFPASGLLLALAVLVWLRPAEEAAPWLQVAALASLALAALYPVALASGGADARLAFALWLRG...WGWFLLGGGLLFLAAFLARRAPALAGACALAGAFVLRSWIVEQGQHSFFVHG
Q72LA6_THET2/2-252             AEFYGLPNAQEFWHWTNALHFVLVGLAGGVALLAALLHLKGDAEARRYTLYALMLIALDLFILWAESPARFRFTHIWLFLSFHPTSPIWWGAWGLGLGFLTGGLLYLGKGSQRALAWALLVFSLVALSYPGLALAVNLNRPLWNGLMAGLFPLTALVLALGLAALLKSPWALFP.LRVLAGASLLLALLYPLTLP...PEAR..GHLLEEAGFWYGLFLLLG....LGTFWQERLAPWAGLLAAAG...LRALLVLAGQWQGL..G
#=GR Q72LA6_THET2/2-252  SS    -EEES--S-S-SS-HHHHHHHHHHHHHHHHHHHHHHHHHCT-TTHCCCHHHHHHHHHHHHHHHHCT-TTCCCT-GGGGCSS--TT-HHHHHHHHHHHHHHHHHHHHTT-S-SSTCHHHHHHHHHHHHHHHHHHHHT-TTSTTS-TTHHHHHHHHHHHHHHHHHHHTT-STTCCH.HHHHHHHHHHHHHHCGGGS-...HHHH..HHHHHHSSCCHHHHHHHH....GGGGSTTTTHHHHHHHHHHH...HHHHHHHHT-----..-
#=GC SS_cons                   -EEES--S-S-SS-HHHHHHHHHHHHHHHHHHHHHHHHHCT-TTHCCCHHHHHHHHHHHHHHHHCT-TTCCCT-GGGGCSS--TT-HHHHHHHHHHHHHHHHHHHHTT-S-SSTCHHHHHHHHHHHHHHHHHHHHT-TTSTTS-TTHHHHHHHHHHHHHHHHHHHTT-STTCCH.HHHHHHHHHHHHHHCGGGS-...HHHH..HHHHHHSSCCHHHHHHHH....GGGGSTTTTHHHHHHHHHHH...HHHHHHHHT-----..-
#=GC seq_cons                  TEFYGLPNApEFWHWTNLLHFlLVGLAGGsAFLTALLHLKGcAEARRYTLaALuLIALDLFlLWAESPARFRFTHVWLFLSFHPTSPIWWGAWGLALSFLouGLLYLGKGPuRsLAWuLLlFSLVALAYPGhALAVNLNRPLWNuLLAGLFPLTALVLALGVAVLLKSuWALaP.LRVLAGASLhLAhLYPlTLs...sEAR..GHLWEEGGhhYGLFLLLG....LGAFhpERLAPWAGhLAAAG...LRALLVtsGQWQGL..G
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