# STOCKHOLM 1.0 #=GF ID NrfD_2 #=GF AC PF14589.8 #=GF DE Polysulfide reductase #=GF AU Coggill P;0000-0001-5731-1588 #=GF SE CATH:2vpzC00, Pfam-B_200168 #=GF GA 27.00 27.00; #=GF TC 27.40 27.20; #=GF NC 26.80 26.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF CL CL0308 #=GF RN [1] #=GF RM 18536726 #=GF RT Molecular mechanism of energy conservation in polysulfide #=GF RT respiration. #=GF RA Jormakka M, Yokoyama K, Yano T, Tamakoshi M, Akimoto S, #=GF RA Shimamura T, Curmi P, Iwata S; #=GF RL Nat Struct Mol Biol. 2008;15:730-737. #=GF DR INTERPRO; IPR032796; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC Bacterial polysulfide reductase is an integral membrane protein #=GF CC complex responsible for quinone-coupled reduction of #=GF CC polysulfide, a process important in extreme environments such as #=GF CC deep-sea vents and hot springs. Polysulfides are a class of #=GF CC compounds composed of chains of sulfur atoms, which in their #=GF CC simplest form are present as an anion with general formula #=GF CC Sn(2-). In nature, polysulfides are found in particularly high #=GF CC concentrations in extreme volcanic or geothermically active #=GF CC environments. Here, the reduction and oxidation of polysulfides #=GF CC are vital processes for many bacteria and are essential steps in #=GF CC the global sulfur cycle. In particular, the reduction of #=GF CC polysulfide to hydrogen sulfide in these environments is usually #=GF CC linked to energy-generating respiratory processes, supporting #=GF CC growth of many microorganisms, particularly hyperthermophiles. #=GF SQ 2 #=GS E4U7V7_OCEP5/1-254 AC E4U7V7.1 #=GS E4U7K8_OCEP5/1-265 AC E4U7K8.1 E4U7V7_OCEP5/1-254 MTGEWGIYIVLYFW..........LAAMGGGAFLIA.LGLRDERARRSGAFLAFIGIVIGALLLIVDLGQPVRFWH..LLVGFHPISVMWLGSAVLALSGLGLFLLLV....MREWPGWLVWVTAILVLLVVGYTGVLLMA.TARPFWSGSPLMPWIFLASAYTTGAALLVLLGNRE...PGLHRISFNFALIEIVLVVAHLIWTYP..LAKNAVQAALTGELAWAFWGFVVLGVALPLYMEA..QRRAASLAALLVLAGGFLLRYFIVYAGQTG..VLRF E4U7K8_OCEP5/1-265 MTTFYGLPGAEAFWHWTTLVHFLLVALAGGTAFYTAVLGIRRAASARGLAWLALAFIVLDLFMLWAESPARFRFSHVWLFLSFEPASAIWWGAWGLATSALMLLLLALGLGPARFWAGVLALTSAV....VLAYPGYALAANAARPLW..DHLLLAFFPASGLLLALAVLVWLRPAEEAAPWLQVA....ALASLALAA.....LYPVALASGGADARLAFALWLRGWGWFLLGGGL.LFLAAFLARRAPALAGACALAGAFVLRSWIVEQGQHSFFVHGF #=GC seq_cons MTs.aGl.hs.hFW..........lAhhGGsAFhhA.LGlRcttutRuhAaLAhhhIVlshhhLhs-.st.hRF.H..LhluFcPhSshWhGuhsLAhSuLhLhLLhl....hR.WsGhLshsoAl....VluYsGhhLhA.sARPhW..s.Lh.hhF.ASuhhhuhAlLVhLtstE...PhLphh....ALhplsLss.....hYP..LApsuspAtLshtLhhthWGahlLGsuL.LahtA..tRRAsuLAuhhsLAGuFlLR.aIV.tGQpu..VhtF //