Summary: Acidic N-terminal SPT6
Acidic N-terminal SPT6 Provide feedback
The N-terminus of SPT6 is highly acidic. The full SPT6 protein is a transcription regulator, but the exact function of this acidic region is not certain.
McDonald SM, Close D, Xin H, Formosa T, Hill CP;, Mol Cell. 2010;40:725-735.: Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding. PUBMED:21094070 EPMC:21094070
Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bahler J, Winston F;, Mol Cell Biol. 2011;31:4193-4204.: Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. PUBMED:21844224 EPMC:21844224
Swanson MS, Carlson M, Winston F;, Mol Cell Biol. 1990;10:4935-4941.: SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus. PUBMED:2201908 EPMC:2201908
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This family is new in this Pfam release.
|Seed source:||pfam-B_9510 (release 26.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||58|
|Number in full:||252|
|Average length of the domain:||90.40 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||6.20 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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