Summary: Rapamycin-insensitive companion of mTOR RasGEF_N domain
Rapamycin-insensitive companion of mTOR RasGEF_N domain Provide feedback
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM;, Curr Biol. 2004;14:1296-1302.: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. PUBMED:15268862 EPMC:15268862
Internal database links
|SCOOP:||Arm_2 V-ATPase_H_N KAP DRIM UME RIX1 DUF1981|
|Similarity to PfamA using HHSearch:||RasGEF_N|
External database links
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Curation and family details
This family is new in this Pfam release.
|Seed source:||Pfam-B_389 (release 26.0)|
|Number in seed:||35|
|Number in full:||251|
|Average length of the domain:||112.50 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||8.19 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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