# STOCKHOLM 1.0
#=GF ID   FANCI_S1
#=GF AC   PF14675.1
#=GF DE   FANCI solenoid 1
#=GF AU   Eberhardt R
#=GF SE   Jackhmmer:Q9NVI1
#=GF GA   25.00 25.00;
#=GF TC   25.40 26.90;
#=GF NC   23.20 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21764741
#=GF RT   Structure of the FANCI-FANCD2 complex: insights into the Fanconi
#=GF RT   anemia DNA repair pathway.
#=GF RA   Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O,
#=GF RA   Elledge SJ, Pavletich NP;
#=GF RL   Science. 2011;333:312-316.
#=GF CC   This is the solenoid 1 (S1) domain of the Fanconi anemia group I
#=GF CC   protein [1].
#=GF SQ   16
#=GS B4QGN7_DROSI/55-279  AC B4QGN7.1
#=GS B5DZ45_DROPS/64-288  AC B5DZ45.1
#=GS B4MPL1_DROWI/55-279  AC B4MPL1.1
#=GS B4LNT0_DROVI/63-287  AC B4LNT0.1
#=GS D7FNN8_ECTSI/95-373  AC D7FNN8.1
#=GS B3KNW8_HUMAN/60-281  AC B3KNW8.1
#=GS F2Z414_MOUSE/60-281  AC F2Z414.1
#=GS D2JYR7_XENLA/60-282  AC D2JYR7.1
#=GS E7FB45_DANRE/66-288  AC E7FB45.1
#=GS B0I564_CHICK/60-283  AC B0I564.1
#=GS D6WCF1_TRICA/39-264  AC D6WCF1.1
#=GS E2BQZ8_HARSA/58-277  AC E2BQZ8.1
#=GS E2AAC5_CAMFO/58-282  AC E2AAC5.1
#=GS B0W1E3_CULQU/62-288  AC B0W1E3.1
#=GS Q7Q1S0_ANOGA/57-283  AC Q7Q1S0.4
#=GS E3XGA2_ANODA/62-310  AC E3XGA2.1
B4QGN7_DROSI/55-279             DALAKRFECVRSFMDGLSSTELSYKQTFDLITRLSQDLATFPSEQLAWIVEHCMDGI........................RQGDAKCVGWKDLLPDALSL......LLAR.PRFLLNGISIDGTEFRDTTVRSIATMQWPASILTPIADMFKTINLSSGEIVTVLNKFSGALQE.LSPMELPALCFQLFSVC.STASQLIIPLLALEKYFHRNYYKRLFSDMCSNST....NLDSI......................DLFSDKELREAEETILHHLNYCTMY
B5DZ45_DROPS/64-288             ESKKKRFALVQCFMDGLRSIELNYKQSFDLITRLAQDLPTFSADELAWIIEHCVDGM........................RQGDAKCVGWKDLLPDSLAL......LSAT.PRFILNGVGTDGTEYRNNTVKSICTMRWPSSILTPIADMFKAINLSNGEILTVLNKFSGALQE.LSPMELPALCFQLFSMC.QNASQLIVPLLALEKYFQRNYYKRLFSDMSSNST....DFDSI......................DPFSDKELREAEETILHHLNYCTMY
B4MPL1_DROWI/55-279             ESCEKRFACVCHFLDGLRTLELSYKQTFDLIARLSQDLVTFSPSELVWIVDHCVDGL........................RLGDAKCVGWKDLLPETLIV......LTAT.PQFLVNGVSTNGLQYRNSIINSLSTMRWPATILTPIADMFRALHLSNAEILTVLNKFAGALQE.LSPMELPALCFQLFSMC.NSASKLIIPLLALEKYFHRNYYKRLFSDMCSNST....DLDSI......................DSFSDKELREAEETILHHLNYCTMY
B4LNT0_DROVI/63-287             ETQEKRFACVRCFLDGLRKVEMGYKLTIDLITRICQDLGSYTADHLNWIVEHCMDDM........................RAGDAKCVAWKDLLPETLLV......LAVQ.PRLIINGIAMTGPELRDTTVRNLSAMRWPIAILTPIADMFSMLKLSNGERFTVLNKFAGALQD.LSPMELPALCFQLFSMC.TSAAQLIIPLLALEKYFHRNYYKRLFSDMCSNST....DLDSI......................DAFSDKELREAEETVLHHLNYCTMY
D7FNN8_ECTSI/95-373             GTAARVQEIAVVGIKAIHSGLVVDKPAQELQNVLLAELGDISPDHAPAIVNAVLAPLLEASKCQGRLTVGHQRQSSEREMSEEAAASFLVVLDILPKVLSVTAGVPTLSEE.DPVPEDVRGLSGAQYKDRVVSCLFRARWPGAVSVGMCQTLRDLDLGERHLSVAVSRVLRHLRKNAKLHDLPALTYQLLLLAGRGCKEAA..LEGVIQVFNRLDAEAADREDAAAGAAGGIPIRPI..SGGRGGGGGGSIGRGGGGGLGTNSTEELRFVEGTILLHFNFAMKQ
B3KNW8_HUMAN/60-281             AGTLRRRKIYTCCIQLVESGDLQKEIVSEIIGLLMLEAHHFPGPLLVELANEFISAV........................REGSLVNGKSLELLPIILTA......LATKKENLAYGKGVLSGEECKKQLINTLCSGRWDQQYVIQLTSMFKDVPLTAEEVEFVVEKALSMFSK.MNLQEIPPLVYQLLVLSSKGSRKSV..LEGIIAFFSALDKQHNEEQSGDELL....DV..V.......................TVPSGELRHVEGTIILHIVFAIKL
F2Z414_MOUSE/60-281             DGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAV........................REDRLVNGKSLELLPIILTA......LATKKEVLACGKGDLNGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLTMFSK.LNLQEIPPLVYQLLVLSSKGSRRSV..LDGIIAFFRELDKQHREEQSSDELS....EL..I.......................TAPADELYHVEGTVILHIVFAIKL
D2JYR7_XENLA/60-282             VAVRRRLAVYRHCIQLVESGDLQREVASEIMGLLMLEVHHFPGASLIELANLFADAV........................KAGTLSNGKSLDLFPTVLTA......LSSK.ESLAYGKGELTGEEFKKQLINSLCSSRWDPQSVIFLTSMFRDVSLSAEELQFVVEKVLRMLSK.LDLQEMPPLVYQLLLLSAKGSKKNI..VEGIITIFNDLDQKQLVQQENSESL....DLEDA.......................TIPQDQLHHVEGTIILHIVFAIKL
E7FB45_DANRE/66-288             HGANRRLLVYKHCIPLCESGDLQTEVASDIIGLLMLDTHSLPGPALATLASLYVDAI........................KVGEMNSGRSLELFPTILTA......LSAT.DALAYGKGELTGNEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSTEELQFLIEKILRMFLK.LDLQEIPPLVYQLLLLSAKGCKKLV..LEGIINYFKKQDQLQKEEQRNGECE....DVEVQ.......................TIPQDQLRHVEGTVILHIVFAIRL
B0I564_CHICK/60-283             SGVLRRLQVYKHCVSLVESGDLHVGKVSEIIGLLMLEARQLPGHALAELATLFVEVI........................KRGSLSNGKSLELFSTVLTA......LSNSKESLAYGKGELNGEEFKKQLINTLCSSKWDPQCVIHLANMFRDIPLSGEELQFVVEKVLRMFSK.LDLQEIPPLVYQLLLLSAKGSKKTV..LEGIISFFNQLDKRQKEEQRVPQSA....DLEVA.......................TVPLDQLRHVEGTVILHIVSAINL
D6WCF1_TRICA/39-264             NSHNKRYGVVLSVIEELDRSEVSSFHSNAITSRICTELAKFQTEHLLKLCDFCVESL........................QSGRVSQMSWKEILPQLLNV......LSKK.EHVDVEGEEISGIEYKHQVINNICTLQWSPNIVVNLTQMFIDLSLSKEEHLQVVNKLAKQLEK.MTPQEVPPFVYQLLKFCKNSSASVI..FIKLQHYFALRYHDKFLDQTASSSE..SSEMDLI......................EDASSQDILEAEATVLYHIHSLAFV
E2BQZ8_HARSA/58-277             NLYSKRLKLVESTLKVLAKAKVSISHVNDIVNRIVVDFPNYPKLHLIRLVEFCLTSI........................RNNDDEFRSWKDLLPVLLEV......LEEE.KYINYMNGEVSGSKYKSLIINNICISEWNTEIMPSIAMMFRDMSLEKEDHTLVFTVLCTRLQN.IPLEELPPFVHQALRFCNNQDSKHL..LEALRRYFTTRFSQINSDDINTFET.....IDTV.........................SAKEIQDVESTVLYHIYQAAQL
E2AAC5_CAMFO/58-282             KLYSKRLKLVESVLKTLGKAKVSINYVNDIVTRIVEDFPNYPKLHLIKLVDFCLARI........................RNNEDEFRSWKDLLPILLEV......LEEE.KCINYMNGEVSGSKYKSIIVNNICNSEWNTEIMPSLTKMFRDISLQKEDHTTVITVLCTRMQN.IPLEEVPPFVHQSLRLCTNQDSKLL..LEALRRYFAQCFSQANSDSVDTFETKLKKEFSMI.........................NPREVQDIESTVLYHIYQAAQL
B0W1E3_CULQU/62-288             KTSDKRFQITMAVLQQLNRVELATKVAFDIVSRLVLDLPKFGPDQLVEILEYCVESI........................RAGDPKCMGWKDLLPDVLSL......LSQQVGRISVNGFIMTGVEYRKKVLDELFKMKIQNGILTSFTGMFREVQLSREEATLLVGKVCDAIRH.LEALEIPALTFQLFHVCLKYSSLLVLPIYALQKYFHKHYYKKIASNDCGDST....DFDSI......................EPVSDKELREAEETILYHLSNVTEF
Q7Q1S0_ANOGA/57-283             RCAGRRFELVMAVLQHLNVVELSTKQVFDLIARLLTDLPSLTPEQLVEICELCIESI........................RAGDPKCLTWKHLLPQTLLQ......LSGNAGRLNANGMLLTGAEYRQKVLEEIFKMKLQLAILTALCGMFRDLTLSKDETSIFVTKVSDSLKN.IEPLELPPLACQLFHVCLKHPSLLVVPLMALQKYFHKNYYKKVLSNENSDTT....DFDSI......................DRYSDSEIREAEETILFHLSNVTEF
E3XGA2_ANODA/62-310             ACREKRFELIMAVLRHTNVVELSTKQMFDLIARLLTDLPTFSSEQLVEMCELCIESI........................RLGDPKCLSWKHLLPQTLAQ......LNDSVGRFNANGMLLTGTDYRIKVLGELFKMKLLPAILTPLCAMFRDFNLSREETATFVTKISDSIKQ.IEPLELPPLAFQLFRVCLKNPGQLIVPLMALQKYFHKNYYKKVLSNANSDTT....DFDSIGEWMLENQQHDKNATQASSSRTDRYSDTEIREAEETILYHLSNVTEF
#=GC seq_cons                   pstp+Rhplspsslptlcss-Lshchs.DlIuRLhhDlssassppLlcls-hCl-ul........................RtG-spshsWK-LLPplLss......Lusp.tplshsshtloGsEY+cpllssLssh+WsspIlsslssMFRDlsLSpEEhphVlsKlsstlpc.ls..ElPPLsaQLhplC.psuupll..L.uLp+YFpcpahc+h.sptsopoo....Dl-sI.......................shSscELR-sEtTlLaHls.ssph
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