# STOCKHOLM 1.0 #=GF ID FANCI_S1 #=GF AC PF14675.7 #=GF DE FANCI solenoid 1 #=GF AU Eberhardt R;0000-0001-6152-1369 #=GF SE Jackhmmer:Q9NVI1 #=GF GA 25.00 25.00; #=GF TC 25.20 25.70; #=GF NC 23.50 24.70; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 21764741 #=GF RT Structure of the FANCI-FANCD2 complex: insights into the Fanconi #=GF RT anemia DNA repair pathway. #=GF RA Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, #=GF RA Elledge SJ, Pavletich NP; #=GF RL Science. 2011;333:312-316. #=GF DR INTERPRO; IPR029308; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This is the solenoid 1 (S1) domain of the Fanconi anemia group I #=GF CC protein [1]. #=GF SQ 27 #=GS H3BEB6_LATCH/62-281 AC H3BEB6.1 #=GS W5NBC0_LEPOC/64-278 AC W5NBC0.1 #=GS M3ZFI5_XIPMA/61-280 AC M3ZFI5.2 #=GS H2RKZ1_TAKRU/57-276 AC H2RKZ1.2 #=GS F6U1I1_XENTR/62-281 AC F6U1I1.1 #=GS F6ZAA0_HORSE/151-369 AC F6ZAA0.2 #=GS F2Z414_MOUSE/62-280 AC F2Z414.1 #=GS F2UC89_SALR5/162-396 AC F2UC89.1 #=GS W4XSR8_STRPU/66-282 AC W4XSR8.1 #=GS K1RGE4_CRAGI/65-281 AC K1RGE4.1 #=GS E9FS18_DAPPU/75-295 AC E9FS18.1 #=GS B4LNT0_DROVI/65-286 AC B4LNT0.2 #=GS B4MPL1_DROWI/57-278 AC B4MPL1.1 #=GS B4HSC1_DROSE/66-287 AC B4HSC1.1 #=GS B4GI47_DROPE/66-287 AC B4GI47.1 #=GS B0W1E3_CULQU/64-287 AC B0W1E3.1 #=GS Q7Q1S0_ANOGA/59-282 AC Q7Q1S0.4 #=GS W5J4J4_ANODA/64-287 AC W5J4J4.1 #=GS D6WCF1_TRICA/63-284 AC D6WCF1.2 #=GS K7J1W5_NASVI/62-283 AC K7J1W5.1 #=GS E2AAC5_CAMFO/60-281 AC E2AAC5.1 #=GS E2BQZ8_HARSA/60-276 AC E2BQZ8.1 #=GS J9JMK7_ACYPI/73-284 AC J9JMK7.2 #=GS D7FNN8_ECTSI/97-372 AC D7FNN8.1 #=GS F0ZVY5_DICPU/230-451 AC F0ZVY5.1 #=GS H9G4R5_ANOCA/62-282 AC H9G4R5.2 #=GS F1P1Z1_CHICK/62-282 AC F1P1Z1.2 H3BEB6_LATCH/62-281 IQRRLHVYKHCVQLAESGD.LQMEVVSEIIGLLMLETHQLPGPALVELASLYVDAIKEGS...............................ISNG.KSLELFPTVLTALS......AE.ESLAYGKGQL.SGEEYKKQLINSLCSSRWDPQAVIHFTSMFRDVPLSAEEL...QFVMDKVIRMF.SKLDLQEIPPLVYQLLLLSAKGGKKRV..LEGIIAFFSQQDEK......QKEEQKDSESLE...................VEIASVPRDQLHH....VEGTVILHVVFAVK W5NBC0_LEPOC/64-278 VSHRLLVYKHCIQLCESGD.LQLEVVSDIVGLLMLEVQDAP..HLLQLSQC...PPCGGE...............................LPAG.LGLRSLLTVPQALA......AT.ETLTYGKGEL.SGEEYKKQLINSLCSSRWDPQSVIHLTSMFRDVPLSVEEL...QFVVEKVLRMF.SKLDLQEIPPSVYQLLLLTAKGCKKLV..LEGVINYFNEQDRQ......QKEGQKDSESVG...................VDVAPVPQDQLRH....VEGTVILHVVFAVR M3ZFI5_XIPMA/61-280 ANRRLLVYEHLIPLCESGD.LQAEVAADIIGLLMLETHTLSGSSLAKLATLFVDAIKVGK...............................MGSG.KSLELFPTILTALA......AC.AALSYGKGEL.SGEEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSAEEL...QFLVDKVLRMF.FKMDLQEVPPLVYQLLLLSAKGCKKPI..LDGIVGYFRDQDDR......QEEEQKDGVNLH...................LEVQTIPQDQLRH....VEGTVILHIVFAIR H2RKZ1_TAKRU/57-276 SNRRLLVYQHCIPLCESGD.LQAEVAADIIGLLMLETHALPGSCLAQLATLFLEAIKGGK...............................IGNG.KSLELFPTVITALS......AC.ETLSYGKGEL.SGEEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSTEEL...RFLIEKILRML.TKLDLQEVPPLVYQLLLLSAKGCKKQI..LDGIISYFKEQDDC....LEEERKKGNSMDL.....................EVQSMPQDELRH....VEGTTVIHIVFALR F6U1I1_XENTR/62-281 VQRRLTVYRHCIQLVESGD.LQREVASEIMGLLMLEVHLFPGASLIELANLFVDAVKGGS...............................LSNG.KSLDLFPTVLSALS......SK.ESLAYGKGEL.TGEEFKKQLINSLCSSRWDPQSVIFLTSMFRDVSLSVEEL...QFVVEKVLRML.SKLDLQEMPPLVYQLLLLSAKGSKKNI..VEGIITIFNDLDQK......QLIQQENSISLD...................LEDATIPQDQLCH....VEGTIILHIVFAIK F6ZAA0_HORSE/151-369 ALRRLKIYTCCIQLVESGD.LHKEVASEIIGLLMLEAHNFPGPLLVELANEFVGAIKEGS...............................LMNG.KSLELLPIILTALA.....TKK.ENLAYGKGEL.NGEECKKQLINALCSGRWNQQYVIQLTSMFRDVPLTAEEM...EFVMEKVLRMF.SKLNLQEIPPLVYQLLVLSSKGSRKKV..LEGIISFFSELDKQ......HNEEQSGDELL.....................DLVTVPSGELRH....VEGTIILHIVFAIK F2Z414_MOUSE/62-280 ALRRYKIYSCCIQLVESGD.LQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDR...............................LVNG.KSLELLPIILTALA.....TKK.EVLACGKGDL.NGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEM...NLVVAKVLTMF.SKLNLQEIPPLVYQLLVLSSKGSRRSV..LDGIIAFFRELDKQ......HREEQSSDELSE....................L.ITAPADELYH....VEGTVILHIVFAIK F2UC89_SALR5/162-396 ....ESVCLFLMQLIEDPG.LHATLCSDLLDVLMVGVDSLSGDGLVAVCTQILRAVKAANGNEITQNSTTATPMSPNNKPSPSKRRGTQPRTGTG.KVFELMPKALSRLE..........TLDAITGELDTGNAFKSFFLNRLCNMPWPPQHVLPIADAFKTVNFDADQF...KFAAAKLVRSL.HDVATEEVPPLVYQLLLLSAKGQRAVI..LQGVLAFCAAQSSA.......................................AVQAPTAALRHALTQAQGTVLMHISFAVK W4XSR8_STRPU/66-282 ...RVLLCKSALKVLGGQE.VSSKMASEIIGYLLIEIGNFPVSCLVEIADMFMDAVKSKD...............................IRNG.RAFELLPKVISTLA......AM.ETVTKDSNRM.SGQEFKDHLLNNFCSCRWESQCAIHLASVFREIPLSSDQL...QFVINKLLRVL.KHVDLQELPPLVYQLLLLSSKGHKKIV..LEGLTGFFAEQDRR......LQERQGKENGEE...................LVSSSFSKELLRH....TEGTIIIHITFSIK K1RGE4_CRAGI/65-281 ....TALYKRCIEILEKNE.LSSKLASNLAGMLLLETDLLQNSALAEICSLFIDMVKSGS...............................IQCG.KGLALLPKILSVIA......LE.ETVSYGESSL.NGEKYKSHVINSLCSCKWNSQSVLHLAGMFKDIALTNEEL...RFVLEKIIRMM.KDLELTDLPSLVYQLLLLSTKGHKKLV..IDGVTKYFIEQDAR......HKDHDPNEFSEDL..................LEGDNASIETLRQ....TEGTIILHINFAIS E9FS18_DAPPU/75-295 .....NVMKSILTELCDSEAVPENCAVDIVHLMSLNSHDLSSNNLAELVQLCLSFIEKGK...............................NLKG.KWLSLFPMIFSELA......KQ.NRVNVEGNTL.TGEEYCSEIISSLCETEIATDDAVAFTAVLRELKIPPSTV...NKFVLKLCAIV.PEMEPQEVPPFVYQLLFLCYQSDHLVP..LQHLTKYFDNKLRRCGQIANISSSRGNSMDIE...................SEIESGSPKEILQ....AKATSIFHIFRAA. B4LNT0_DROVI/65-286 QEKRFACVRCFLDGLRKVE.MGYKLTIDLITRICQDLGSYTADHLNWIVEHCMDDMRAGD...............................AKCV.AWKDLLPETLLVLA......VQ.PRLIINGIAM.TGPELRDTTVRNLSAMRWPIAILTPIADMFSMLKLSNGER...FTVLNKFAGAL.QDLSPMELPALCFQLFSMCTSAAQLII.PLLALEKYFHRNYYK..RLFSDMCSNSTDLDS......................IDAFSDKELRE....AEETVLHHLNYCTM B4MPL1_DROWI/57-278 CEKRFACVCHFLDGLRTLE.LSYKQTFDLIARLSQDLVTFSPSELVWIVDHCVDGLRLGD...............................AKCV.GWKDLLPETLIVLT......AT.PQFLVNGVST.NGLQYRNSIINSLSTMRWPATILTPIADMFRALHLSNAEI...LTVLNKFAGAL.QELSPMELPALCFQLFSMCNSASKLII.PLLALEKYFHRNYYK..RLFSDMCSNSTDLDS......................IDSFSDKELRE....AEETILHHLNYCTM B4HSC1_DROSE/66-287 LAKRFECVRSFMDGLSSTE.LSYKQTFDLITRLSQDLATFPSEQLAWIVEHCMDGIRQGD...............................AKCV.GWKDLLPDALSLLL......AR.PRFLLNGISI.DGTEFRDTTVRSIATMQWPASILTPIADMFKSMNLSSAEI...VTVLNKFSGAL.QELSPMELPALCFQLFSMCSTASQLII.PLLALEKYFHRNYYK..RLFSDMCSNSTNLDS......................IDLFSDKELRE....AEETILHHLNYCTM B4GI47_DROPE/66-287 KKKRFALVQCFMDGLRSVE.LNYKQSFDLITRLAQDLPTFSADELAWIIEHCVDGMRQGD...............................AKCV.GWKDLLPDSLALLS......AT.PRFILNGVGT.DGTEYRNNTVKSICTMRWPSSILTPIADMFKAINLSNGEI...LTVLNKFSGAL.QELSPMELPALCFQLFSMCQNASQLIV.PLLALEKYFQRNYYK..RLFSDMSSNSTDFDS......................IDPFSDKELRE....AEETILHHLNYCTM B0W1E3_CULQU/64-287 SDKRFQITMAVLQQLNRVE.LATKVAFDIVSRLVLDLPKFGPDQLVEILEYCVESIRAGD...............................PKCM.GWKDLLPDVLSLLS......QQVGRISVNGFIM.TGVEYRKKVLDELFKMKIQNGILTSFTGMFREVQLSREEA...TLLVGKVCDAI.RHLEALEIPALTFQLFHVCLKYSSLLVLPIYALQKYFHKHYYK..KIASNDCGDSTDFDS......................IEPVSDKELRE....AEETILYHLSNVTE Q7Q1S0_ANOGA/59-282 AGRRFELVMAVLQHLNVVE.LSTKQVFDLIARLLTDLPSLTPEQLVEICELCIESIRAGD...............................PKCL.TWKHLLPQTLLQLS......GNAGRLNANGMLL.TGAEYRQKVLEEIFKMKLQLAILTALCGMFRDLTLSKDET...SIFVTKVSDSL.KNIEPLELPPLACQLFHVCLKHPSLLVVPLMALQKYFHKNYYK..KVLSNENSDTTDFDS......................IDRYSDSEIRE....AEETILFHLSNVTE W5J4J4_ANODA/64-287 REKRFELIMAVLRHTNVVE.LSTKQMFDLIARLLTDLPTFSSEQLVEMCELCIESIRVGD...............................PKCL.SWKHLLPQTLAQLN......DSVGRFNANGMLL.TGTDYRIKVLGELFKMKLLPAILTPLCAMFRDFNLSREET...ATFVTKISDSI.KQIEPLELPPLAFQLFRVCLKNPGQLIVPLMALQKYFHKNYYK..KVLSNANSDTTDFDS......................IDRYSDTEIRE....AEETILYHLSNVTE D6WCF1_TRICA/63-284 HNKRYGVVLSVIEELDRSE.VSSFHSNAITSRICTELAKFQTEHLLKLCDFCVESLQSGR...............................VSQM.SWKEILPQLLNVLS......KK.EHVDVEGEEI.SGIEYKHQVINNICTLQWSPNIVVNLTQMFIDLSLSKEEH...LQVVNKLAKQL.EKMTPQEVPPFVYQLLKFCKNSSASVI..FIKLQHYFALRYHDKFLDQTASSSESSEMDL......................IEDASSQDILE....AEATVLYHIHSLA. K7J1W5_NASVI/62-283 HDKWQKLVKAIFDALKKTK.VTSKHAENIVSRIVVDFPMFERAHLVKLVDYFLDRIRNND...............................DDFM.SWKDVLPLLLERLE......EE.NNINHRGSDV.TGKDYKIIIIRSICDIDWEPSILTSLAKMFVELMAEVKDKVIWDTIMKALTNKL.MTVDLNELPPLAHQMLKLGCEHNSTLL..FSTLSKYFAENYVNVSDDDANSQETSESII.......................SSKVSLKELQE....VESTVIYYIYQ... E2AAC5_CAMFO/60-281 YSKRLKLVESVLKTLGKAK.VSINYVNDIVTRIVEDFPNYPKLHLIKLVDFCLARIRNNE...............................DEFR.SWKDLLPILLEVLE......EE.KCINYMNGEV.SGSKYKSIIVNNICNSEWNTEIMPSLTKMFRDISLQKEDH...TTVITVLCTRM.QNIPLEEVPPFVHQSLRLCTNQDSKLL..LEALRRYFAQCFSQAN.SDSVDTFETKLKKE......................FSMINPREVQD....IESTVLYHIYQAAQ E2BQZ8_HARSA/60-276 YSKRLKLVESTLKVLAKAK.VSISHVNDIVNRIVVDFPNYPKLHLIRLVEFCLTSIRNND...............................DEFR.SWKDLLPVLLEVLE......EE.KYINYMNGEV.SGSKYKSLIINNICISEWNTEIMPSIAMMFRDMSLEKEDH...TLVFTVLCTRL.QNIPLEELPPFVHQALRFCNNQDSKHL..LEALRRYFTTRFSQIN.SDDINTFET...........................IDTVSAKEIQD....VESTVLYHIYQAAQ J9JMK7_ACYPI/73-284 ...VENVYEYVLNAINNAE.IPEKMKVCLISRLSLELNKLSTKQLIKFINMCKKDIEESN...............................ENCVQSWKELFPHILKIVS......EI.KLIRTEELEM.TGADYKEMIITDICRFKVQPNISVALALMFRGTLLTEKEH...ELVIKTLCSYF.GQMKPLEIPPILQQILHFCSSGDFLTL..FCTLQKYFDDKYHLDQSNDANCALE............................IEGSEKKEFLE....AESTVLFLLED... D7FNN8_ECTSI/97-372 AARVQEIAVVGIKAIHSGL.VVDKPAQELQNVLLAELGDISPDHAPAIVNAVLAPLLEASKCQGRLTVGHQR.......QSSEREMSEEAAASFL.VVLDILPKVLSVTAGVPTLSEE.DPVPEDVRGL.SGAQYKDRVVSCLFRARWPGAVSVGMCQTLRDLDLGERHL...SVAVSRVLRHLRKNAKLHDLPALTYQLLLLAGRGCKEAA..LEGVIQVFNRLDAEAADREDAAAGAAGGIPIRPISGGRGGGGGGSIGRGGGGGLGTNSTEELRF....VEGTILLHFNFAMK F0ZVY5_DICPU/230-451 ....EILQEFVKQIIQYKSGIEEKQLNQCVDILLSECDGINRQSYRDIAESIADTLHSNR.................................RA.PILLLLPKSLEQLSFLSTPASM.E..........SDESFKSQIIKKIVESEWNKEIFISTISMLNDLQLNKSDL...ELVINKIFNES.KDLIKDEYISLVHQLILLSSKGLKGVI..MKGICELFSNIEKSEQDRELGYNDNNNYTSSFKM...............INNHGESNNLNELFC....VESIIFQQLNISIK H9G4R5_ANOCA/62-282 VVRRLSVYKHCIQLVESGD.LHVESASEIIRLLMLEAHKLPGPALADLATLFVDAVKGGG...............................LLSG.KSLELFPTVLTALA.....TSK.ETLVYGTGEL.NGEELKKQLINTLCSSRWGHQHVIHLTSMFRDVPLSTEEL...QFVVEKVLRMF.PKLDLQEIPPLVYQLLLLSSKGSKKNI..LQGIINFFNQMDKK......LKEEQKNSESMD...................LEEATVPADQLRH....VEGTIVLHIVLAIN F1P1Z1_CHICK/62-282 VLRRLQVYKHCVSLVESGD.LHVGKVSEIIGLLMLEARQLPGHALAELATLFVEVIKRGS...............................LSNG.KSLELFSTVLTALS.....NSK.ESLAYGKGEL.NGEEFKKQLINTLCSSKWDPQCVIHLANMFRDIPLSGEEL...QFVVEKVLRMF.SKLDLQEIPPLVYQLLLLSAKGSKKTV..LEGIISFFNQLDKR......QKEEQRVPQSAD...................LEVATVPLDQLRH....VEGTVILHIVSAIN #=GC seq_cons ht+Rhplhppslphlcss-.Lptchss-lluhLhl-hsshssspLsclsshhl-ul+sGc...............................hpss.phh-LLPplLssLu......tp.pplshstspl.oGpEYKpplIssLCsh+WssphlltlssMFRDlsLos-Eh...phVlsKlhphh.pclshpElPPLVaQLLhLss+uspphl..LpulhpYFpcp.pc......pppppssshs.......................lsshspcELRc....sEuTllhHlshuhp //