# STOCKHOLM 1.0
#=GF ID   FANCI_S1
#=GF AC   PF14675.7
#=GF DE   FANCI solenoid 1
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:Q9NVI1
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.70;
#=GF NC   23.50 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21764741
#=GF RT   Structure of the FANCI-FANCD2 complex: insights into the Fanconi
#=GF RT   anemia DNA repair pathway.
#=GF RA   Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O,
#=GF RA   Elledge SJ, Pavletich NP;
#=GF RL   Science. 2011;333:312-316.
#=GF DR   INTERPRO; IPR029308;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is the solenoid 1 (S1) domain of the Fanconi anemia group I
#=GF CC   protein [1].
#=GF SQ   27
#=GS H3BEB6_LATCH/62-281   AC H3BEB6.1
#=GS W5NBC0_LEPOC/64-278   AC W5NBC0.1
#=GS M3ZFI5_XIPMA/61-280   AC M3ZFI5.2
#=GS H2RKZ1_TAKRU/57-276   AC H2RKZ1.2
#=GS F6U1I1_XENTR/62-281   AC F6U1I1.1
#=GS F6ZAA0_HORSE/151-369  AC F6ZAA0.2
#=GS F2Z414_MOUSE/62-280   AC F2Z414.1
#=GS F2UC89_SALR5/162-396  AC F2UC89.1
#=GS W4XSR8_STRPU/66-282   AC W4XSR8.1
#=GS K1RGE4_CRAGI/65-281   AC K1RGE4.1
#=GS E9FS18_DAPPU/75-295   AC E9FS18.1
#=GS B4LNT0_DROVI/65-286   AC B4LNT0.2
#=GS B4MPL1_DROWI/57-278   AC B4MPL1.1
#=GS B4HSC1_DROSE/66-287   AC B4HSC1.1
#=GS B4GI47_DROPE/66-287   AC B4GI47.1
#=GS B0W1E3_CULQU/64-287   AC B0W1E3.1
#=GS Q7Q1S0_ANOGA/59-282   AC Q7Q1S0.4
#=GS W5J4J4_ANODA/64-287   AC W5J4J4.1
#=GS D6WCF1_TRICA/63-284   AC D6WCF1.2
#=GS K7J1W5_NASVI/62-283   AC K7J1W5.1
#=GS E2AAC5_CAMFO/60-281   AC E2AAC5.1
#=GS E2BQZ8_HARSA/60-276   AC E2BQZ8.1
#=GS J9JMK7_ACYPI/73-284   AC J9JMK7.2
#=GS D7FNN8_ECTSI/97-372   AC D7FNN8.1
#=GS F0ZVY5_DICPU/230-451  AC F0ZVY5.1
#=GS H9G4R5_ANOCA/62-282   AC H9G4R5.2
#=GS F1P1Z1_CHICK/62-282   AC F1P1Z1.2
H3BEB6_LATCH/62-281              IQRRLHVYKHCVQLAESGD.LQMEVVSEIIGLLMLETHQLPGPALVELASLYVDAIKEGS...............................ISNG.KSLELFPTVLTALS......AE.ESLAYGKGQL.SGEEYKKQLINSLCSSRWDPQAVIHFTSMFRDVPLSAEEL...QFVMDKVIRMF.SKLDLQEIPPLVYQLLLLSAKGGKKRV..LEGIIAFFSQQDEK......QKEEQKDSESLE...................VEIASVPRDQLHH....VEGTVILHVVFAVK
W5NBC0_LEPOC/64-278              VSHRLLVYKHCIQLCESGD.LQLEVVSDIVGLLMLEVQDAP..HLLQLSQC...PPCGGE...............................LPAG.LGLRSLLTVPQALA......AT.ETLTYGKGEL.SGEEYKKQLINSLCSSRWDPQSVIHLTSMFRDVPLSVEEL...QFVVEKVLRMF.SKLDLQEIPPSVYQLLLLTAKGCKKLV..LEGVINYFNEQDRQ......QKEGQKDSESVG...................VDVAPVPQDQLRH....VEGTVILHVVFAVR
M3ZFI5_XIPMA/61-280              ANRRLLVYEHLIPLCESGD.LQAEVAADIIGLLMLETHTLSGSSLAKLATLFVDAIKVGK...............................MGSG.KSLELFPTILTALA......AC.AALSYGKGEL.SGEEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSAEEL...QFLVDKVLRMF.FKMDLQEVPPLVYQLLLLSAKGCKKPI..LDGIVGYFRDQDDR......QEEEQKDGVNLH...................LEVQTIPQDQLRH....VEGTVILHIVFAIR
H2RKZ1_TAKRU/57-276              SNRRLLVYQHCIPLCESGD.LQAEVAADIIGLLMLETHALPGSCLAQLATLFLEAIKGGK...............................IGNG.KSLELFPTVITALS......AC.ETLSYGKGEL.SGEEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSTEEL...RFLIEKILRML.TKLDLQEVPPLVYQLLLLSAKGCKKQI..LDGIISYFKEQDDC....LEEERKKGNSMDL.....................EVQSMPQDELRH....VEGTTVIHIVFALR
F6U1I1_XENTR/62-281              VQRRLTVYRHCIQLVESGD.LQREVASEIMGLLMLEVHLFPGASLIELANLFVDAVKGGS...............................LSNG.KSLDLFPTVLSALS......SK.ESLAYGKGEL.TGEEFKKQLINSLCSSRWDPQSVIFLTSMFRDVSLSVEEL...QFVVEKVLRML.SKLDLQEMPPLVYQLLLLSAKGSKKNI..VEGIITIFNDLDQK......QLIQQENSISLD...................LEDATIPQDQLCH....VEGTIILHIVFAIK
F6ZAA0_HORSE/151-369             ALRRLKIYTCCIQLVESGD.LHKEVASEIIGLLMLEAHNFPGPLLVELANEFVGAIKEGS...............................LMNG.KSLELLPIILTALA.....TKK.ENLAYGKGEL.NGEECKKQLINALCSGRWNQQYVIQLTSMFRDVPLTAEEM...EFVMEKVLRMF.SKLNLQEIPPLVYQLLVLSSKGSRKKV..LEGIISFFSELDKQ......HNEEQSGDELL.....................DLVTVPSGELRH....VEGTIILHIVFAIK
F2Z414_MOUSE/62-280              ALRRYKIYSCCIQLVESGD.LQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDR...............................LVNG.KSLELLPIILTALA.....TKK.EVLACGKGDL.NGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEM...NLVVAKVLTMF.SKLNLQEIPPLVYQLLVLSSKGSRRSV..LDGIIAFFRELDKQ......HREEQSSDELSE....................L.ITAPADELYH....VEGTVILHIVFAIK
F2UC89_SALR5/162-396             ....ESVCLFLMQLIEDPG.LHATLCSDLLDVLMVGVDSLSGDGLVAVCTQILRAVKAANGNEITQNSTTATPMSPNNKPSPSKRRGTQPRTGTG.KVFELMPKALSRLE..........TLDAITGELDTGNAFKSFFLNRLCNMPWPPQHVLPIADAFKTVNFDADQF...KFAAAKLVRSL.HDVATEEVPPLVYQLLLLSAKGQRAVI..LQGVLAFCAAQSSA.......................................AVQAPTAALRHALTQAQGTVLMHISFAVK
W4XSR8_STRPU/66-282              ...RVLLCKSALKVLGGQE.VSSKMASEIIGYLLIEIGNFPVSCLVEIADMFMDAVKSKD...............................IRNG.RAFELLPKVISTLA......AM.ETVTKDSNRM.SGQEFKDHLLNNFCSCRWESQCAIHLASVFREIPLSSDQL...QFVINKLLRVL.KHVDLQELPPLVYQLLLLSSKGHKKIV..LEGLTGFFAEQDRR......LQERQGKENGEE...................LVSSSFSKELLRH....TEGTIIIHITFSIK
K1RGE4_CRAGI/65-281              ....TALYKRCIEILEKNE.LSSKLASNLAGMLLLETDLLQNSALAEICSLFIDMVKSGS...............................IQCG.KGLALLPKILSVIA......LE.ETVSYGESSL.NGEKYKSHVINSLCSCKWNSQSVLHLAGMFKDIALTNEEL...RFVLEKIIRMM.KDLELTDLPSLVYQLLLLSTKGHKKLV..IDGVTKYFIEQDAR......HKDHDPNEFSEDL..................LEGDNASIETLRQ....TEGTIILHINFAIS
E9FS18_DAPPU/75-295              .....NVMKSILTELCDSEAVPENCAVDIVHLMSLNSHDLSSNNLAELVQLCLSFIEKGK...............................NLKG.KWLSLFPMIFSELA......KQ.NRVNVEGNTL.TGEEYCSEIISSLCETEIATDDAVAFTAVLRELKIPPSTV...NKFVLKLCAIV.PEMEPQEVPPFVYQLLFLCYQSDHLVP..LQHLTKYFDNKLRRCGQIANISSSRGNSMDIE...................SEIESGSPKEILQ....AKATSIFHIFRAA.
B4LNT0_DROVI/65-286              QEKRFACVRCFLDGLRKVE.MGYKLTIDLITRICQDLGSYTADHLNWIVEHCMDDMRAGD...............................AKCV.AWKDLLPETLLVLA......VQ.PRLIINGIAM.TGPELRDTTVRNLSAMRWPIAILTPIADMFSMLKLSNGER...FTVLNKFAGAL.QDLSPMELPALCFQLFSMCTSAAQLII.PLLALEKYFHRNYYK..RLFSDMCSNSTDLDS......................IDAFSDKELRE....AEETVLHHLNYCTM
B4MPL1_DROWI/57-278              CEKRFACVCHFLDGLRTLE.LSYKQTFDLIARLSQDLVTFSPSELVWIVDHCVDGLRLGD...............................AKCV.GWKDLLPETLIVLT......AT.PQFLVNGVST.NGLQYRNSIINSLSTMRWPATILTPIADMFRALHLSNAEI...LTVLNKFAGAL.QELSPMELPALCFQLFSMCNSASKLII.PLLALEKYFHRNYYK..RLFSDMCSNSTDLDS......................IDSFSDKELRE....AEETILHHLNYCTM
B4HSC1_DROSE/66-287              LAKRFECVRSFMDGLSSTE.LSYKQTFDLITRLSQDLATFPSEQLAWIVEHCMDGIRQGD...............................AKCV.GWKDLLPDALSLLL......AR.PRFLLNGISI.DGTEFRDTTVRSIATMQWPASILTPIADMFKSMNLSSAEI...VTVLNKFSGAL.QELSPMELPALCFQLFSMCSTASQLII.PLLALEKYFHRNYYK..RLFSDMCSNSTNLDS......................IDLFSDKELRE....AEETILHHLNYCTM
B4GI47_DROPE/66-287              KKKRFALVQCFMDGLRSVE.LNYKQSFDLITRLAQDLPTFSADELAWIIEHCVDGMRQGD...............................AKCV.GWKDLLPDSLALLS......AT.PRFILNGVGT.DGTEYRNNTVKSICTMRWPSSILTPIADMFKAINLSNGEI...LTVLNKFSGAL.QELSPMELPALCFQLFSMCQNASQLIV.PLLALEKYFQRNYYK..RLFSDMSSNSTDFDS......................IDPFSDKELRE....AEETILHHLNYCTM
B0W1E3_CULQU/64-287              SDKRFQITMAVLQQLNRVE.LATKVAFDIVSRLVLDLPKFGPDQLVEILEYCVESIRAGD...............................PKCM.GWKDLLPDVLSLLS......QQVGRISVNGFIM.TGVEYRKKVLDELFKMKIQNGILTSFTGMFREVQLSREEA...TLLVGKVCDAI.RHLEALEIPALTFQLFHVCLKYSSLLVLPIYALQKYFHKHYYK..KIASNDCGDSTDFDS......................IEPVSDKELRE....AEETILYHLSNVTE
Q7Q1S0_ANOGA/59-282              AGRRFELVMAVLQHLNVVE.LSTKQVFDLIARLLTDLPSLTPEQLVEICELCIESIRAGD...............................PKCL.TWKHLLPQTLLQLS......GNAGRLNANGMLL.TGAEYRQKVLEEIFKMKLQLAILTALCGMFRDLTLSKDET...SIFVTKVSDSL.KNIEPLELPPLACQLFHVCLKHPSLLVVPLMALQKYFHKNYYK..KVLSNENSDTTDFDS......................IDRYSDSEIRE....AEETILFHLSNVTE
W5J4J4_ANODA/64-287              REKRFELIMAVLRHTNVVE.LSTKQMFDLIARLLTDLPTFSSEQLVEMCELCIESIRVGD...............................PKCL.SWKHLLPQTLAQLN......DSVGRFNANGMLL.TGTDYRIKVLGELFKMKLLPAILTPLCAMFRDFNLSREET...ATFVTKISDSI.KQIEPLELPPLAFQLFRVCLKNPGQLIVPLMALQKYFHKNYYK..KVLSNANSDTTDFDS......................IDRYSDTEIRE....AEETILYHLSNVTE
D6WCF1_TRICA/63-284              HNKRYGVVLSVIEELDRSE.VSSFHSNAITSRICTELAKFQTEHLLKLCDFCVESLQSGR...............................VSQM.SWKEILPQLLNVLS......KK.EHVDVEGEEI.SGIEYKHQVINNICTLQWSPNIVVNLTQMFIDLSLSKEEH...LQVVNKLAKQL.EKMTPQEVPPFVYQLLKFCKNSSASVI..FIKLQHYFALRYHDKFLDQTASSSESSEMDL......................IEDASSQDILE....AEATVLYHIHSLA.
K7J1W5_NASVI/62-283              HDKWQKLVKAIFDALKKTK.VTSKHAENIVSRIVVDFPMFERAHLVKLVDYFLDRIRNND...............................DDFM.SWKDVLPLLLERLE......EE.NNINHRGSDV.TGKDYKIIIIRSICDIDWEPSILTSLAKMFVELMAEVKDKVIWDTIMKALTNKL.MTVDLNELPPLAHQMLKLGCEHNSTLL..FSTLSKYFAENYVNVSDDDANSQETSESII.......................SSKVSLKELQE....VESTVIYYIYQ...
E2AAC5_CAMFO/60-281              YSKRLKLVESVLKTLGKAK.VSINYVNDIVTRIVEDFPNYPKLHLIKLVDFCLARIRNNE...............................DEFR.SWKDLLPILLEVLE......EE.KCINYMNGEV.SGSKYKSIIVNNICNSEWNTEIMPSLTKMFRDISLQKEDH...TTVITVLCTRM.QNIPLEEVPPFVHQSLRLCTNQDSKLL..LEALRRYFAQCFSQAN.SDSVDTFETKLKKE......................FSMINPREVQD....IESTVLYHIYQAAQ
E2BQZ8_HARSA/60-276              YSKRLKLVESTLKVLAKAK.VSISHVNDIVNRIVVDFPNYPKLHLIRLVEFCLTSIRNND...............................DEFR.SWKDLLPVLLEVLE......EE.KYINYMNGEV.SGSKYKSLIINNICISEWNTEIMPSIAMMFRDMSLEKEDH...TLVFTVLCTRL.QNIPLEELPPFVHQALRFCNNQDSKHL..LEALRRYFTTRFSQIN.SDDINTFET...........................IDTVSAKEIQD....VESTVLYHIYQAAQ
J9JMK7_ACYPI/73-284              ...VENVYEYVLNAINNAE.IPEKMKVCLISRLSLELNKLSTKQLIKFINMCKKDIEESN...............................ENCVQSWKELFPHILKIVS......EI.KLIRTEELEM.TGADYKEMIITDICRFKVQPNISVALALMFRGTLLTEKEH...ELVIKTLCSYF.GQMKPLEIPPILQQILHFCSSGDFLTL..FCTLQKYFDDKYHLDQSNDANCALE............................IEGSEKKEFLE....AESTVLFLLED...
D7FNN8_ECTSI/97-372              AARVQEIAVVGIKAIHSGL.VVDKPAQELQNVLLAELGDISPDHAPAIVNAVLAPLLEASKCQGRLTVGHQR.......QSSEREMSEEAAASFL.VVLDILPKVLSVTAGVPTLSEE.DPVPEDVRGL.SGAQYKDRVVSCLFRARWPGAVSVGMCQTLRDLDLGERHL...SVAVSRVLRHLRKNAKLHDLPALTYQLLLLAGRGCKEAA..LEGVIQVFNRLDAEAADREDAAAGAAGGIPIRPISGGRGGGGGGSIGRGGGGGLGTNSTEELRF....VEGTILLHFNFAMK
F0ZVY5_DICPU/230-451             ....EILQEFVKQIIQYKSGIEEKQLNQCVDILLSECDGINRQSYRDIAESIADTLHSNR.................................RA.PILLLLPKSLEQLSFLSTPASM.E..........SDESFKSQIIKKIVESEWNKEIFISTISMLNDLQLNKSDL...ELVINKIFNES.KDLIKDEYISLVHQLILLSSKGLKGVI..MKGICELFSNIEKSEQDRELGYNDNNNYTSSFKM...............INNHGESNNLNELFC....VESIIFQQLNISIK
H9G4R5_ANOCA/62-282              VVRRLSVYKHCIQLVESGD.LHVESASEIIRLLMLEAHKLPGPALADLATLFVDAVKGGG...............................LLSG.KSLELFPTVLTALA.....TSK.ETLVYGTGEL.NGEELKKQLINTLCSSRWGHQHVIHLTSMFRDVPLSTEEL...QFVVEKVLRMF.PKLDLQEIPPLVYQLLLLSSKGSKKNI..LQGIINFFNQMDKK......LKEEQKNSESMD...................LEEATVPADQLRH....VEGTIVLHIVLAIN
F1P1Z1_CHICK/62-282              VLRRLQVYKHCVSLVESGD.LHVGKVSEIIGLLMLEARQLPGHALAELATLFVEVIKRGS...............................LSNG.KSLELFSTVLTALS.....NSK.ESLAYGKGEL.NGEEFKKQLINTLCSSKWDPQCVIHLANMFRDIPLSGEEL...QFVVEKVLRMF.SKLDLQEIPPLVYQLLLLSAKGSKKTV..LEGIISFFNQLDKR......QKEEQRVPQSAD...................LEVATVPLDQLRH....VEGTVILHIVSAIN
#=GC seq_cons                    ht+Rhplhppslphlcss-.Lptchss-lluhLhl-hsshssspLsclsshhl-ul+sGc...............................hpss.phh-LLPplLssLu......tp.pplshstspl.oGpEYKpplIssLCsh+WssphlltlssMFRDlsLos-Eh...phVlsKlhphh.pclshpElPPLVaQLLhLss+uspphl..LpulhpYFpcp.pc......pppppssshs.......................lsshspcELRc....sEuTllhHlshuhp
//