Summary: Bifunctional transglycosylase second domain
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Bifunctional transglycosylase second domain Provide feedback
UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle .
Sung MT, Lai YT, Huang CY, Chou LY, Shih HW, Cheng WC, Wong CH, Ma C;, Proc Natl Acad Sci U S A. 2009;106:8824-8829.: Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. PUBMED:19458048 EPMC:19458048
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Curation and family details
This family is new in this Pfam release.
|Number in seed:||119|
|Number in full:||1054|
|Average length of the domain:||84.40 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||10.57 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UB2H domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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