Summary: Pathogen effector; putative necrosis-inducing factor
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Pathogen effector; putative necrosis-inducing factor Provide feedback
The domain corresponds to the mature part of the Ecp2 effector protein from the tomato pathogen Cladopsorium fulvum. Effectors are low molecular weight proteins that are secreted by bacteria, oomycetes and fungi to manipulate their hosts and adapt to their environment. Ecp2 is a 165 amino acid secreted protein that was originally identified as a virulence factor in C. fulvum, since disruption reduces virulence of the fungus on tomato plants. We have recently determined that Ecp2 is a member of a novel, widely distributed and highly diversified within the fungal kingdom multigene superfamily, which we have designated Hce2, for Homologs of C. fulvum Ecp2 effector. Although Ecp2 is present in most organisms as a small secreted protein, the mature part of this protein can be found fused to other protein domains, including the fungal Glycoside Hydrolase family 18, Glyco_hydro_18 PF00704 and other, unknown, protein domains. The intrinsic function of Ecp2 remains unknown but it is postulated by  that it is a necrosis-inducing factor in plants that serves pathogenicity on the host.
Van den Ackerveken GF, Van Kan JA, Joosten MH, Muisers JM, Verbakel HM, De Wit PJ;, Mol Plant Microbe Interact. 1993;6:210-215.: Characterization of two putative pathogenicity genes of the fungal tomato pathogen Cladosporium fulvum. PUBMED:8471794 EPMC:8471794
Lauge R, Joosten MH, Haanstra JP, Goodwin PH, Lindhout P, De Wit PJ;, Proc Natl Acad Sci U S A. 1998;95:9014-9018.: Successful search for a resistance gene in tomato targeted against a virulence factor of a fungal pathogen. PUBMED:9671796 EPMC:9671796
Stergiopoulos I, van den Burg HA, Okmen B, Beenen HG, van Liere S, Kema GH, de Wit PJ;, Proc Natl Acad Sci U S A. 2010;107:7610-7615.: Tomato Cf resistance proteins mediate recognition of cognate homologous effectors from fungi pathogenic on dicots and monocots. PUBMED:20368413 EPMC:20368413
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This family is new in this Pfam release.
|Author:||Stergiopoulos I, Coggill P|
|Number in seed:||39|
|Number in full:||124|
|Average length of the domain:||102.60 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||20.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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