Summary: Effector protein
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Effector protein Provide feedback
This family of proteins contains an HEXXH motif, typical of zinc metallopeptidases. The family includes the E. coli effector protein NleD, which cleaves and inactivates c-Jun N-terminal kinase (JNK) .
Baruch K, Gur-Arie L, Nadler C, Koby S, Yerushalmi G, Ben-Neriah Y, Yogev O, Shaulian E, Guttman C, Zarivach R, Rosenshine I;, EMBO J. 2011;30:221-231.: Metalloprotease type III effectors that specifically cleave JNK and NF-kappaB. PUBMED:21113130 EPMC:21113130
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR028208
This entry represents Escherichia coli effector protein NleD-like proteins.
Enteropathogenic E. coli infection can trigger an inflammatory response in host cells. This inflammatory response can then be inhibited by injecting several effectors that block the NF-kappa B pathway to the host cells. One of these effectors from E. coli, NleD, cleaves and inactivates c-Jun N-terminal kinase (JNK), which is a serine/threonine kinase that affects the regulation of cellular proliferation, apoptosis, inflammation, and tumorigenesis [PUBMED:21113130]. NleD contains an HEXXH motif, typical of zinc metallopeptidases [PUBMED:21113130].
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Clan MA is one of two zinc-dependent metallopeptidases that contain the HEXXH motif. The two histidines are zinc ligands. The structures of this clan show the active site is between its two sub-domains.
The clan contains the following 58 members:Aspzincin_M35 Astacin BSP DUF1570 DUF2201_N DUF2268 DUF3152 DUF3267 DUF3633 DUF3810 DUF4157 DUF4344 DUF45 DUF4953 DUF955 HRXXH Peptidase_M1 Peptidase_M10 Peptidase_M11 Peptidase_M13 Peptidase_M2 Peptidase_M27 Peptidase_M3 Peptidase_M30 Peptidase_M32 Peptidase_M35 Peptidase_M36 Peptidase_M4 Peptidase_M41 Peptidase_M43 Peptidase_M48 Peptidase_M4_C Peptidase_M50 Peptidase_M50B Peptidase_M54 Peptidase_M56 Peptidase_M57 Peptidase_M6 Peptidase_M60 Peptidase_M61 Peptidase_M64 Peptidase_M66 Peptidase_M7 Peptidase_M8 Peptidase_M9 Peptidase_M91 Peptidase_Mx Peptidase_Mx1 Peptidase_U49 Reprolysin Reprolysin_2 Reprolysin_3 Reprolysin_4 Reprolysin_5 SprT-like WLM Zn_peptidase Zn_peptidase_2
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Curation and family details
|Number in seed:||13|
|Number in full:||431|
|Average length of the domain:||162.90 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||42.90 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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