# STOCKHOLM 1.0 #=GF ID APCDDC #=GF AC PF14921.7 #=GF DE Adenomatosis polyposis coli down-regulated 1 #=GF AU Coggill P;0000-0001-5731-1588 #=GF GA 27.0 27.0 #=GF NC 26.8 26.0 #=GF TC 27.2 28.3 #=GF SE Jackhmmer:Q8NCL9 #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 12384519 #=GF RT Isolation of a novel human gene, APCDD1, as a direct target of #=GF RT the beta-Catenin/T-cell factor 4 complex with probable #=GF RT involvement in colorectal carcinogenesis. #=GF RA Takahashi M, Fujita M, Furukawa Y, Hamamoto R, Shimokawa T, Miwa #=GF RA N, Ogawa M, Nakamura Y; #=GF RL Cancer Res. 2002;62:5651-5656. #=GF RN [2] #=GF RM 20393562 #=GF RT APCDD1 is a novel Wnt inhibitor mutated in hereditary #=GF RT hypotrichosis simplex. #=GF RA Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, #=GF RA Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, #=GF RA Christiano AM; #=GF RL Nature. 2010;464:1043-1047. #=GF DR INTERPRO; IPR029405; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC The domain is duplicated in most members of this family. APCDD #=GF CC is directly regulated by the beta-catenin/Tcf complex, and its #=GF CC elevated expression promotes proliferation of colonic epithelial #=GF CC cells in vitro and in vivo [1]. APCDD1 has an N-terminal #=GF CC signal-peptide and a C-terminal transmembrane region. The #=GF CC domain is rich in cysteines, there being up to 12 such residues, #=GF CC a structural motif important for interaction between Wnt ligands #=GF CC and their receptors. APCDD1 is expressed in a broad repertoire #=GF CC of cell types, indicating that it may regulate a diverse range #=GF CC of biological processes controlled by Wnt signalling [2]. #=GF SQ 98 F1NSX1.2/26-266 RCRQQLRHLQDGARIA-ARLPP.RLEGQWVS.TGCEVRPG........PEFLTRSYLFY.......A..N..R.....L.FKAFQF.YYWDPSCREPSYSLVIKG.......KL.R.L......R.QA...SWI..TRG...ATEADYH......LHKVGIVFHSQKAMREVASR.INQSsg.egC..SGFL..PPGRAWAPR......ALYELLS-........-AKTE-................................RDC.T.A.ALG..FA..M..H..ELSLVRVERHHQPl........................................................pgLQ.QSGSS....LVEE.LYLGDIHTDW...L..E..R.L..H...Y...RPTGYQRP.LQSVVHH..MHPCPACGVIYRADEHHPPILP F1NSX1.2/270-452 ------------------ELPV.QLSGSWVS.TRCEVRPA........VLFLTRYFIFH......gS..N..H.....T.WQGYYY.HYSDPLCKQPTFTIYASG.......RY.T.Q......G.VP...SSK..VRG...GMELAFK......VTQARVTPMDQVTVMMLNSS.EPGS.....C..-GLA..SSWS---AG......VEQDITP-........--T---................................NGC.L.AlGIR..LP..H..T..EYELFRTEHDPKE...........................................................--.-----....-RSL.LYIGERPTDG...S..SpdR.P..D...K...RPTSYQAP.LVQCAA-..---------------------- Q8J025.1/51-282 QCHHMLKHLHNGARIT-VQMPP.TIEGHWVS.TGCEVRSG........PEFITRSYRFY.......H..N..N.....T.FKAYQF.YYGSNRCTNPTYTLIIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LHNVQVICHTEAVAEKLGQQ.VNRT.....C..PGFL..ADGGPWVQD......VAYDLWR-........-EENG-................................CEC.T.K.AVN..FA..M..H..ELQLIRVEKQYLH...........................................................--.HNLDH....LVEE.LFLGDIHTDA...T..Q..R.M..F...Y...RPSSYQPP.LQNAKNH..DHACIACRIIYRSDEHHPPILP Q8J025.1/290-466 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPVCKHPTFSIYARG.......RY.S.R......G.VL...SSR..VMG...GTEFVFK......VNHMKVTPMDAATASLLNVF.NGNE.....C..-GAE..GSWQ---VG......IQQDVTH-........---TN-................................-GC.V.AlGIK..LP..H..T..EYEIFKMEQDARG...........................................................--.-----....-RYL.LFNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LVQC---..---------------------- F1M5Q7.2/51-282 QCHHMLKHLHNGARIT-VQMPP.TIEGHWVS.TGCEVRSG........PEFITRSYRFY.......N..N..N.....T.FKAYQF.YYGSNRCTNPTYTLIIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LHGVQVICHTEAVAEQLSRL.VNRT.....C..PGFL..ASGGPWVQD......VAYDLWQ-........-EESS-................................HEC.T.K.AVN..FA..M..H..ELQLIRVEKQYPH...........................................................--.HSLDH....LVEE.LFLGDIHTDA...T..Q..R.V..F...Y...RPSSYQPP.LQNAKNH..NHACIACRIIYRSDEHHPPILP F1M5Q7.2/290-466 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPVCKHPTFTIYARG.......RY.S.R......G.VL...SSR..VMG...GTEFVFK......VNHMKVTPMDAATASLLNVF.SGNE.....C..-GAE..GSWQ---VG......IQQDVTH-........---TN-................................-GC.V.AlGIK..LP..H..T..EYEIFKMEQDARG...........................................................--.-----....-RYL.LFNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LVQC---..---------------------- Q3U128.1/51-282 QCHHMLKHLHNGARIT-VQMPP.TIEGHWVS.TGCEVRSG........PEFMTRSYRFY.......N..N..N.....T.FKAYQF.YYGSNRCTNPTYTLIIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LHGVQVICHTEAVAEQLSRL.VNRT.....C..PGFL..APGGPWVQD......VAYDLWQ-........-EESN-................................HEC.T.K.AVN..FA..M..H..ELQLIRVEKQYPH...........................................................--.HSLDH....LVEE.LFLGDIHTDA...T..Q..R.V..F...Y...RPSSYQPP.LQNAKNH..NHACIACRIIFRSDEHHPPILP Q3U128.1/290-466 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPVCKHPTFTIYARG.......RY.S.R......G.VL...SSK..VMG...GTEFVFK......VNHMKVTPMDAATASLLNVF.SGNE.....C..-GAE..GSWQ---VG......IQQDVTH-........---TN-................................-GC.V.AlGIK..LP..H..T..EYEIFKMEQDTRG...........................................................--.-----....-RYL.LFNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LVQC---..---------------------- M7BN41.1/35-266 QCPHMLKHLHNGARIT-VQMPP.TIEGHWVS.TGCEVRSG........PEFITRSYRFY.......H..N..N.....T.FKAYQF.YYGGNRCTNPTYTLVIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LHNIQIICHSEAVAEKLREL.VNRT.....C..PGFV..PDSNPWEQD......VSYNLWR-........-EENG-................................CEC.T.R.ALN..FA..M..H..ELQLIRVEKQYLH...........................................................--.HNLDH....LVEE.LFLGDIHTDA...T..Q..R.M..Y...Y...RPSSYQPP.LQNAKNH..DHTCIACRIIYRSDEHHPPILP M7BN41.1/274-450 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPICKHPTFTIYAKG.......RY.S.R......G.VH...SSK..VMG...GTEFVFK......VNHMKVTPMDIATASLLNVF.NGNE.....C..-GAE..GSWQVGVQQ......DVTHTN--........------................................-GC.V.AlGIR..LP..H..T..EYEIFKMEQDARG...........................................................--.-----....-SYL.LYNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LVQC---..---------------------- Q5R2I8.1/51-282 QCHHMLKHLHNGARIT-VQMPP.NIEGHWVS.TGCEVRAG........PEFITRSYRFY.......H..N..N.....T.FKAYQF.YYGGNRCTNPIYTLVIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LRNIQIISHNEAVAKKLSEL.VNNT.....C..PGFI..PEDSPWEQD......VSYDLLR-........-EENG-................................CEC.T.K.ALN..FA..M..H..ELQLIRVEKQYLH...........................................................--.HNLDH....LVEE.LFLGDIHTDA...T..Q..R.R..Y...Y...RPSSYQPP.LQNAKNH..DRTCIACRIIYRSDEHHPPILP Q5R2I8.1/290-465 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPICKHPTFTIYAKG.......RY.S.R......G.VH...SAK..VMG...GTEFVFK......VNHMKVTPMDVSTASLLNVF.NGNE.....C..-GAQ..GSWQVGVQQ......DVTHTN--........------................................-GC.I.AlGIR..LP..H..T..EYEIFKMEQDARG...........................................................--.-----....-RYL.LYNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LIQ----..---------------------- A0A3M0KRG8.1/51-282 QCHHMLKHLHNGARIT-VQMPP.NIEGHWVS.TGCEVRAG........PEFITRSYRFY.......H..N..N.....T.FKAYQF.YYGGNRCTNPIYTLVIRG.......KI.R.L......R.QA...SWI..IRG...GTEADYQ......LRGIQIICHNEAVAKKLSEL.VNQT.....C..PGFI..PEDSPWEQD......VSYDLLR-........-EENG-................................CEC.T.K.ALN..FA..M..H..ELQLIRVEKQYLH...........................................................--.HNLDH....LVEE.LFLGDIHTDA...T..Q..R.R..Y...Y...RPSSYQPP.LQNAKNH..DRTCIACRIIYRSDEHHPPILP A0A3M0KRG8.1/290-465 ----------------------.GLHGEWVS.QRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HYSDPICKHPTFTIYAKG.......RY.S.R......G.VH...SSK..VMG...GTEFVFK......VNHMKVTPMDISTASLLNVF.NGNE.....C..-GAQ..GSWQVGVQQ......DVTHTN--........------................................-GC.I.AlGIR..LP..H..T..EYEIFKMEQDARG...........................................................--.-----....-RYL.LYNGQRPSDG...SspD..R.P..E...K...RATSYQMP.LIQ----..---------------------- E7F3Y0.1/52-282 QCQAQLRHLQNEGRIT-ATIPP.KLEGHWVS.SRCEVRPG........PEFLTRSYTLY.......QspT..R.....L.FRALQH.YYSDSECQVPTYSLVIRG.......KL.R.L......R.QA...SWI..TRG...ATEAEHH......LHKVGMVIHSQKAIHHLATR.LPSS.....C..LGLK..AE-GHLVLH......RFYELFN-........-AKAE-................................KDC.L.G.ALG..FS..M..M..ELELLRVETHHHP...........................................................--.--HGR....PAQE.LFLGDVHTEW...N..E..R.V..H...Y...RPSGYQEP.LQNAMHH..IHPCPVCGLVYRASEQHPPILP E7F3Y0.1/288-467 ---------------------PlNLNGNWVS.QRCESRPA........VLFLTRLFVFN......eE..Q..H.....T.WEGTYH.HYSDPTCRQPSFTLSASG.......NY.V.K......V.GQ...SIK..VRG...ATELVFK......VTHAKVIVFDRALLRELNST.QNGR.....C..-GQA..---GGWEAG......IEQDITW-........---TN-................................-GC.D.AlGIR..LP..H..K..EYELFKMEVDRKG...........................................................--.-----....-HPL.LFNGERPTDG...SspE..R.P..A...K...RPTSFQTP.MVQCS--..---------------------- A0A2R8PWP3.1/35-265 QCQAQLRHLQNEGRIT-ATIPP.KLEGHWVS.SRCEVRPG........PEFLTRSYTLY.......QspT..R.....L.FRALQH.YYSDSECHVPTYSLVIRG.......KL.R.L......R.QA...SWI..TLG...ATEAEHH......LHKVGMVIHSQKAIHHLATR.LPSS.....C..LGLK..AE-GHLVLH......RFYELFN-........-AKAE-................................KDC.L.G.ALG..FS..M..M..ELELLRVETHHHP...........................................................--.--HGR....PAQE.LFLGDVHTDW...N..E..R.V..H...Y...RPSGYQEP.LQNAMHH..IHPCPVCGLVYRASEQHPPILP A0A2R8PWP3.1/271-466 ---------------------PlNLNGNWVS.QRCESRPA........VLFLTRLFAFN......eE..Q..R.....T.WEGTYH.HYSDPTCRQPSFTLSASG.......NY.V.K......V.GQ...SIK..VRG...ATELVFK......VTHAKVIVFDRALLRELNST.QNGR.....C..-GQA..---GGWEAG......IEQDITW-........---TN-................................-GC.D.AlGIR..LP..H..K..EYELFKMEVDRKG...........................................................--.-----....-HPL.LFNGERPTDG...SspE..R.P..A...K...RPTSFQTP.MVQCSTRpkKSSKHDCVLVTM---------- A0A401NWW5.1/51-282 QCHHMLKHLYNGARII-VQMPP.QMESQWVS.TSCEVRPG........PEFITRSYRFY.......S..N..N.....T.FKAYQF.NYGDNHCTHPTYTLVIKG.......KL.R.L......R.QA...SWI..IRG...GTEADYH......LHRVQIICHNQVTAEEMSRK.LNRS.....C..PGFV..PGQKVWEPN......VSYDVWS-........-DESG-................................CNC.F.R.ALN..FA..M..H..ELQLLRVEKQHLH...........................................................--.HNPEH....VMQE.LFLGDIHTDW...S..Q..R.M..Y...Y...RPSSYQPA.LQNAKNH..DHSCMACRIISRSDEHHPPILP A0A401NWW5.1/290-467 ----------------------.GLHGQWAS.RRCEVRPE........VLFLTRHFIFH......dN..N..N.....T.WEGHYY.HFADPLCKHPTFTIYAKG.......RY.S.R......G.IP...STK..VMG...GTEFVFK......VNHMKVTPMDTATASLLNVF.NGNA.....C..-GAE..GSWH---VG......VEQDVTH-........---TN-................................-GC.V.AlGIR..LP..H..T..EYELFKMEQDSKG...........................................................--.-----....-RYL.LFNGQRPSDG...SspD..R.P..E...K...RATSYQAP.LVQCT--..---------------------- M7C5N9.1/5-218 ----------------------.------TV.QSCEVRPG........PEFLTRSYLFY.......S..N..R.....L.FKAYQF.YYWDPSCRHPSHSLVIKG.......KL.R.L......R.QA...SWI..TQG...ATEADYH......LHKVGIVFHSQRAMQEISAR.INQTsg.ggC..SGFF..PPGRSWAPG......VLYEVLS-........-AKEG-................................RDC.T.T.ALG..FA..M..H..ELSLVRVEKHYEPl........................................................lqTQ.PSGSR....TVEE.LYLGDIHTKW...S..E..R.L..H...Y...RPTGYQRP.LQSAVHH..VHPCPACGIIYRSDEHHPPILP M7C5N9.1/222-401 ------------------ELPM.QLSGRWVS.AHCEVRPA........VLFLTRYFIFH......gT..N..R.....T.WEGYYY.HYSDPLCKQPTFTIYASG.......HY.T.K......G.IP...SSI..VRG...GTELAFK......VTCARVTAMDQVTVTMLNSS.EPGT.....C..-GE-..--TGSWSAG......IEQDITL-........---T--................................NGC.L.AlGIK..LP..H..T..EYELFKMEQDMKD...........................................................--.-----....-RSL.LFIGERPTDG...S..SpdR.P..E...K...RPTSYQAP.LIQ----..---------------------- A0A3M0JAE4.1/63-281 ----------------------.-VAQRCLP.RRCEVRPG........PEFLTRSYLFY.......T..N..R.....L.FKALQF.YYWDPSCRDPSYSLVIKG.......KL.R.L......R.QA...SWI..TRG...ATEADYH......LHKVGIVFHSPKAMREVASR.INQTsg.egC..RGFL..PPGRSWAPG......ALYEVLS-........-AKTE-................................RDC.T.A.ALG..FA..M..H..ELSLVRVERRFQPl........................................................lqPQ.QSGSR....LVEE.LYLGDIHTDW...G..E..R.L..H...Y...RPTGYQRP.MQSALHH..VHPCPACVIISRADEHHPPVLP A0A3M0JAE4.1/286-466 -------------------LPM.QLSGSWVS.THCEVRPA........VLFLTRYFTFH......gS..N..H.....S.WEGHYY.HYSDPLCRQPTFTIYASG.......HY.T.Q......G.IP...SSK..VRG...GTELAFK......VTQARVTPMDQVTVVMLNSS.EPGS.....C..-GLA..G---SWSAG......VEQDITP-........---T--................................NGC.L.AlGIK..LP..H..T..EYELFKTEQDTQE...........................................................--.-----....-RSL.LYIGERPTDG...S..S..P.DspD...K...RPTSYQAP.LIQCA--..---------------------- Q8NCL9.1/47-271 --------------ST-AILPP.RLNGPWIS.TGCEVRPG........PEFLTRAYTFY.......P..S..R.....L.FRAHQF.YYEDPFCGEPAHSLLVKG.......KV.R.L......R.RA...SWV..TRG...ATEADYH......LHKVGIVFHSRRALVDVTGR.LNQTragrdC..ARRL..PPARAWLPG......ALYELRS-........-ARAQ-................................GDC.L.E.ALG..LT..M..H..ELSLVRVQRRLQP...........................................................QP.RASPR....LVEE.LYLGDIHTDP...A..E..R.R..H...Y...RPTGYQRP.LQSALHH..VQPCPACGLIARSDVHHPPVLP Q8NCL9.1/277-454 ---------------------PlHLGGWWVS.SGCEVRPA........VLFLTRLFTFH......gH..S..R.....S.WEGYYH.HFSDPACRQPTFTVYAAG.......RY.T.R......G.TP...STR..VRG...GTELVFE......VTRAHVTPMDQVTTAMLNFS.EPSS.....C..GGA-..---GAWSMG......TERDVTA-........---TN-................................-GC.L.PlGIR..LP..H..V..EYELFKMEQDPLG...........................................................--.-----....-QSL.LFIGQRPTDG...S..SpdT.P..E...K...RPTSYQAP.LVL----..---------------------- A0A0G2JVX4.1/24-255 -------PVPKGTPIT-VVPLP.LLTGPWIS.TGCEVRPG........PEFLTRSYTFY.......S..N..H.....L.FRAYQF.YYRDPSCQQPTHSLLIKG.......KV.H.L......R.QA...SWV..TPG...ATEADYH......LHKVGIVFHSHHALLDIARR.LNQTqagqdC..TGRL..PPGQAWLPG......TLYELLS-........-SQVP-................................GDC.M.V.ALG..FS..M..H..ELSLLCLQRHIQQ...........................................................QP.GLAPH....LVEE.LFLGDVHTDW...A..E..R.Q..H...Y...RPTGYQSP.LQSVVHH..TRPCPACSLLAHSNEHRPPVLP A0A0G2JVX4.1/261-366 ---------------------PlRLGGHWVS.VGCEARPA........VLFLTRHFSFD......dR..K..R.....S.WEGRYH.HFSDPACRRPTFTVFAAG.......HY.S.G......G.TP...SPR..VHG...GTELTFV......VTRAHVTPMDRGTTDILNFS.KPSS.....C..GGP-..---------......--------........------................................---.-.-.---..--..-..-..-------------...........................................................--.-----....----.----------...-..-..-.-..-...-...--------.-------..---------------------- Q66HE0.1/36-267 -------PVPKGTPIT-VVPLP.LLTGPWIS.TGCEVRPG........PEFLTRSYTFY.......S..N..H.....L.FRAYQF.YYRDPSCQQPTHSLLIKG.......KV.H.L......R.QA...SWV..TPG...ATEADYH......LHKVGIVFHSHHALLDIARR.LNQTqagqdC..TGRL..PPGQAWLPG......TLYELLS-........-SQVP-................................GDC.M.V.ALG..FS..M..H..ELSLLCLQRHIQQ...........................................................QP.GLAPH....LVEE.LFLGDVHTDW...A..E..R.Q..H...Y...RPTGYQSP.LQSVVHH..TRPCPACSLLAHSNEHRPPVLP Q66HE0.1/273-378 ---------------------PlRLGGHWVS.VGCEARPA........VLFLTRHFSFD......dR..K..R.....S.WEGRYH.HFSDPACRRPTFTVFAAG.......HY.S.G......G.TP...SPR..VHG...GTELTFV......VTRAHVTPMDRGTTDILNFS.KPSS.....C..GGP-..---------......--------........------................................---.-.-.---..--..-..-..-------------...........................................................--.-----....----.----------...-..-..-.-..-...-...--------.-------..---------------------- A0A0G2L4I0.2/47-270 -CVCMLKHLHSGARIT-VQMPP.DIQGHWVS.TSCEVRPG........PEFITRSYRFL.......H..N..S.....S.FSALQF.YYSDVHCSSPTHTLLVRG.......RL.R.L......R.QA...SWI..VRG...GTEADYQ......IQSTRVVFHSESAAAALGLQ.LERG.....C..R---..SISRSWRLN......MSYELWS-........-EEKD-................................SEC.T.A.QIN..FS..M..H..ELQLLRLEKQHLE...........................................................--.----P....ALEE.LYLGDIHTQA...E..H..R.L..T...Y...RPSSYQPA.LHNARNH..DGRCLVCRMVSRSDEFHPPVLP A0A0G2L4I0.2/278-457 ----------------------.VLQGQWAS.RRCEVRPE........VQFLTRHFIFH......dS..N..S.....S.WEGHYY.HYSDPACRHPTFSITARG.......AY.S.R......G.AE...SAR..ISG...ATEYIFT......VQQVCVLPLDVSTVSLLNLS.PGAQ.....C..-GVR..GSWRLGEQQ......DVTATQ--........------................................-GC.A.AlGIR..LP..H..T..EFEIFRSQRLQDG...........................................................--.-----....-RLL.LFNGQRPSDG...S..SpdR.P..E...R...RPSSFQQP.LMQCTEQ..---------------------- E9FTE7.1/1-234 ECSSAFKRVQNGERSAHASYPP.DIKGLWVS.QECETRPG........PEFVLRQYHFE.......R..D..G.....S.FKLLQH.FYGDEWCTTPVYTLTAKG.......QL.Q.M......R.EP...SWV..VPG...AAESEYT......LHRVHLVAYSEDVVDEVMQR.VNRS.....C..PGYI.nRPWRVRKDD......TSLALDE-........------................................IDC.L.A.AFH..AV..Y..H..ELQLIRTKKNFHL...........................................................HP.AVHVQ....PMQTlLFLGNIHSQL...E..Q..R.A..S...Y...RPTSYQPA.LVRHDHQ.eSNDCHVCRLVAKSTDKSPPHLH E9FTE7.1/245-358 ----------------------.---GDWIS.SSCETRPI........GTFLMRRMKFT.......D..H..QnasspT.FQALFH.YFADPVCSNATLTVLATG.......HY.S.P......G.SD...SDR..VQG...ATEFDFF......VQSVIITVHDESTARNLNGL.KGNQ.....C..-AMD..GSWRVDRPQ......--------........------................................---.-.-.---..--..-..-..-------------...........................................................--.-----....----.----------...-..-..-.-..-...-...--------.-------..---------------------- K1R052.1/78-323 -CRQTLSRI--GHLSIEAPQPP.NIAGEWTS.QRCEVRPG........PEFILRRYYF-.......Q..R..H.....H.FKLQQY.YYKDPGCKRPAYGVVAEG.......HY.R.H......K.RP...SWI..VQG...GTETAYT......VHNVSVIPYTSNVARTFTKN.AQF-.....C..TELA.nMNFSTFRKT......KILNFPPYak....nsHDASRD................................FDC.S.F.VFN..LT..F..H..ELQLIRLEIQNHHvyss..................................................ikyfrVV.KAKRA....RTEKlLFLGDIHTDV...K..Q..R.A..S...Y...RPTAYQTA.LRPVFTR..--KCHVCSLIANSHDFLPPQLK K1R052.1/331-511 ----------------------.DLTGEWVS.RRCETRQY........GQFLTRHLSFY.......P..D..G.....S.SWSGQYdFYRDPLCLNPSFTLKVKG.......MY.S.I......K.AD...SKS..IVG...AKNCNFR......IHNLKVKPMSQLITQNLNIF.GGQG.....C..-GRP..KSWETFEEQ......DVTST---........------................................GGC.S.TlGIN..LP..S..V..EHELLKIEKSHNK...........................................................--.-----....--KL.LFIGQRPTDQ...G..V..RpV..G...E...LPTSFQEP.LLQCTNA..QDP------------------- R7UVF9.1/11-226 -----------------SPSPP.DITGTWTS.MRCEVRPG........PEFLLRKYRFY.......E..S..G.....R.FELLQY.YYADAQCTQPMFTLAARG.......RV.R.F......Y.GA...SWV..LPG...ASEMDYS......VSYVTLMPYTKPIAHFLSNK.VNAT.....C..TGYA.kSAWKPFQRY......EILNYVEY........RSNNGY................................EDC.L.D.ALD..FS..L..H..ELQLMRLEERRHQ...........................................................--.---HR....LRTA.LFTGDVHTDR...Q..R..R.R..E...Y...RPTAFQPN.PL-LTHL..DEDCPVCQSVSNSDEFFPPILP R7UVF9.1/234-410 ----------------------.HLAGGWLS.SQCETRPH........NLRLTRHFIFG......aD..N..H.....T.WQASYH.HFYDEICREPMFSLRAEG.......RY.V.V......G.QT...SVL..VDG...AYDVDFY......VESVGITARDPRIARTLNEW.AKGAa...pC..-GGK..---KEWTLG......REQDVTD-........-----S................................KGC.-.P.PLG..IS..M..AaiEKELLRMDHDQHR...........................................................--.-----....---L.LFMGQRPTHA...E..L..N.T..DiplP...RPTSFQPP.LVR----..---------------------- E0VYT8.1/4-256 -------EVSAMDSATTIDQVP.QIEGHWTS.QECEIRPG........PEFLLRNYIFW.......K..N..N.....T.FRLLQH.YYEDESCMIPLYTVIAKG.......VL.T.P......K.ES...SWV..IPS...GIDYDYS......LTKVTVIPHTTQASEKLSIE.KKHK.....CshSGIKksYLNTPWKPH......LEYTLYNK........HEEESKsshhhhhhhkkk.......svrfkrkkghksfSSC.L.S.AMG..FH..F..N..ELMLIRSQWASVE...........................................................--.--GNK....RNRE.LLLGDIHSRK...Q..Q..D.-..-...Y...KPTAFQVP.LLDLENA..-NDCVNCQIIAEGTERTPPMLP E0VYT8.1/266-441 ----------------------.--HGQWVS.RRCEVRPM........GMFLARRLSFD......sR..D..R.....T.WMSEYK.YFSDPFCTESVFAVYSSG.......RY.K.IgpthgkD.KA...LKR..KKT...GTNLDLR......IEEASLTLYDPTLRDTFNA-.-EED.....C..-GI-..---GLWNVG......VAKDLSP-........--TYG-................................--C.SiL.GIS..LP..S..T..EYDLIKLEIDGKG...........................................................--.-----....-TPL.LYLGFQDTDG...K..K..R.N..H..nE...RPTSYQAP.LAQ----..---------------------- A0A1S3KB48.1/44-271 -------HA-SRERVV-VQSLN.KITGQWVS.ERCEVRPG........PEFLLRSYKFQ.......N..D..S.....R.YTAHQY.FYADPACSVPLYSVVSRG.......KL.E.N......I.RD...SWT..IPG...AAEVDYQ......LSQVTLTPYEERQTMVLERM.INST.....C..PELV.kSRWRSYSPY......DIYNYVEV........GSEGGDgiv..........................vldRDC.T.S.VLY..FS..I..H..ELQLIRIEQRHHH...........................................................--.---RR....LKTE.LFLGDIHTDK...T..Q..R.A..S...Y...RPKGFQPP.LVR--TD..SYGCHLCDKMKFTNELEPPRL- A0A1S3KB48.1/277-456 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-------------------ERG.TVDGDWIS.TRCETRPN........SIFVKRRLHFN......lE..D..S.....T.WHGFYS.HFTDPLCAEPSFTLSASG.......TF.T.N......E.GP...SAK..VPG...AREFKFS......VTVMKIRPDTQTYANNLNAE.PVGS.....C..-GIP..GK---WETG......AFQDVQD-........---T--................................GGC.T.RlGVS..VP..Y..V..EYEILKLETTHRS...........................................................--.-----....--TE.LYLGQRPSDG...A..Q..P.SspS...N...RPTSFQPP.LRKCL--..---------------------- A0A210QJD5.1/32-272 ------------DFPTTAPSPP.TIHGVWVS.DRCEIRPG........PEFLLRKYRF-.......K..R..G.....K.FQLHQY.YYSGPDCAEPLYGVKAHG.......TI.K.L......L.RP...SWI..VPG...GMEAKYR......LHNVSIIPFQERIAKEFWFK.VREQ.....C..QGVK..--GHTWKPY......RSYQIMN-........FPPYKKyrlhk......................hrnidYDC.T.Q.LFN..LT..F..H..ELQLLRVEVHRQSgrvdkn...............................................kistypSR.YSKSF....EEVN.LLLGDIHTDR...S..Q..R.H..T...Y...RPSSYQTG.LRNSKTK..--TCQICNGIANSNDYYPPKI- A0A210QJD5.1/281-460 ----------------------.HLQGDWVS.SGCETRQY........GQFLTRKLSFL.......Q..D.gK.....S.WQGQYD.FFEDPLCRKGSFSLSVKG.......TY.T.R......G.KV...SKV..ISR...SKELNFR......LIRLKITPKNKQMVNTLRMY.-DGH.....C..-GVR..NAWKINEQQ......DVTS----........---T--................................GGC.-.D.VLGiiLP..N..V..EFEILRMVTSERQ...........................................................--.-----....--TL.LYVGQWTVNNv.pH..K..N.K..E...L...RPTSFQQP.LVRCSDS..AP-------------------- A7SK84.1/2-228 SCRQIVRHITHYRGIR-SQIRP.DVSGIWTS.SRCEARPG........PKFLTRFVQIF.......S..N..Q.....T.WQADFH.FYSDYQCTKPTFTLHVRG.......AY.W.L......G.NE...AKD..LKG...ATAAHFN......FTTIHIHPHTQAEEVKIVTV.MKKS.....C..PDTL..LNIKETPGI......GVYSATN-........-AAFSK................................RLC.R.T.TFG..IS..D..Y..EFSVLKINTFKML...........................................................S-.----S....KSDL.LYFGEIPTGK...S..R..R.R..-...Y...SPTSYQLP.LK--RNN..APNCTICMVISTASAGVAPIIP A7SK84.1/233-411 --------------------RPvMLNDEWGS.SSCETRPG........GSFLTRYMAFQ......dS..R..S.....H.WEGYYY.YFLDPECRKLNFMIYFKG.......VF.T.S......G.SY...NTK..VRD...GEDYVFT......VTEAAITPHTKSFTRQLNYMsRNNE.....C..----..GKDGEWENG......QSQDITQ-........-----S................................KGCrL.L.GIS..LP..H..T..EYDLLKMVTNENG...........................................................--.-----....-ERE.LYVGQRPTDL...S..S..L.A..Sp.dK...RPTSFQVP.ML-----..---------------------- A0A158NU32.1/21-249 ----------------------.--------.--CEVRAG........PEYIIRKYTFF.......K..N..G.....T.FLLLRY.HYAEESCSIATHTVTIRG.......FI.K.L......L.GS...SAI..VSG...ATETRFH......VDTINIVPLNRQVAHKFGHR.LNLT.....C..-GPQ..PKWRPYIPE......VIYEQPRQ........RSAASSwqgpiynslq............ihssvkkklgMNC.L.E.PFG..IE..F..A..ELKLLRVQKKSFGs.........................................................lSS.NDRYHk..lPQFQ.LFLASPTSNI...H..S..R.W..N...Y...KPTSLQST.AMIRADT..ASDCPICSSVSRSTEFSPPLLH A0A1S3K820.1/69-274 ----------------------.--------.-PCEVRPG........PEFLLRSYKFQ.......N..D..S.....R.YTAHQY.FYADPACSVPLYSVVSRG.......KL.E.N......I.RD...SWT..IPG...AAEVDYQ......LSQVTLTPYEERQTMVLERM.INST.....C..PELV.kSRWRSYSPY......DIYNYVEV........GSEGGDgiv..........................vldRDC.T.S.VLY..FS..I..H..ELQLIRIEQRHHH...........................................................--.---RR....LKTE.LFLGDIHTDK...T..Q..R.A..S...Y...RPKGFQPP.LVR--TD..SYGCHLCDKMKFTNELEPPRL- A0A1S3K820.1/281-459 --------------------RG.TVDGDWIS.TRCETRPN........SIFVKRRLHFN......lE..D..S.....T.WHGFYS.HFTDPLCAEPSFTLSASG.......TF.T.N......E.GP...SAK..VPG...AREFKFS......VTVMKIRPDTQTYANNLNAE.PVGS.....C..-GIP..GK---WETG......AFQDVQD-........---T--................................GGC.T.RlGVS..VP..Y..V..EYEILKLETTHRS...........................................................--.-----....--TE.LYLGQRPSDG...A..Q..P.SspS...N...RPTSFQPP.LRKCL--..---------------------- A0A2J7PDF7.1/1-226 ----------------------.--------.--------........----MRNYMFM.......R..N..H.....T.FRLLQF.HYGDESCTLALYTLTARG.......RY.R.L......T.GR...SWV..TPG...ATEAEYT......LTRVTATAHSAEVAEELAAR.VNTT.....C..PGQV.rRRWKPYRDY......VVLSLPEE.......lA-PSNNqpptgsssyqrrnaasasalgrhqlrmmvtedMDC.L.S.ALH..AV..F..H..ELQLVRVQRRPKG...........................................................-P.PDNRH....PRYE.LLLGDLHSRP...E..L..R.N..S...Y...RPTAFQTP.LL-RADQ..AHGCHICYEVSRSTERSPPHL- A0A2J7PDF7.1/235-408 ----------------------.YMGGEWVS.TRCETRPL........GLFLTRRFRFH......vG..D..R.....T.WNGEYR.FYADPACAVPTFTAAASG.......RYsR.T......L.TT...SGK..VEG...GVEFDFR......VEHASLTVLDRGMVENLQG-.-DRR.....C..----..IPGGVWKVG......VPRDLTP-........-----S................................RGC.S.PlGII..VP..S..T..EYELVRVEMDAQG...........................................................--.-----....-NSL.LFMGQPDTDN...Q..R..R.G.sR...E...RPTAYQLP.LIH----..---------------------- W4ZCA5.1/14-221 ----------------------.--------.--CETRPG........PSFLTRRYKFH.......S..D..H.....S.FTFYQF.YYSDNQCQSPAYSYRVRG.......QL.T.I......G.GL...TFT..LDG...ANEALYE......LEKVTLTVFQDRFAMMLAQQ.LNGS.....C..PGML..EPNQPLAIF......RKYIVLDN........SRDVVQ................................IDC.T.P.GLG..FT..M..N..ELQLIRQEVYERR...........................................................VE.DTGTV....RRSEtLYLGDIHTDP...A..Q..M.I..I...H...RSKGYQTP.LRKYDDD.sENYCAVCQIVYNAREHAPPILP W4ZCA5.1/229-403 ----------------------.ALSGGWVS.VHCEVRH-........IYFLTRHLIFF.......D..N..Q.....T.WEGHYH.FYRDPLCQFPKYTVSVKG.......TR.T.A......G.EP...SAI..VEG...ATNFKFT......SLAMYLTPQCDKEVERFNSK.-NVG.....C..-G--..-RRGAWKVG......RTLDVTS-........---AG-................................-GCdV.L.GVN..LP..H..M..EFELVKTVPDPEE...........................................................--.-----....-GLL.LFTGQRPSDG...QtpN..T.E..S...L...RATSFQSP.LLHCS--..---------------------- C3YEG5.1/29-109 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----------------------.SLQGEWVS.TRCESRQY........GQFLTRWLHFL.......G..D..G.....LsWEGRYE.YYHDALCRQPTFTLRAKG.......SY.-.-......-.--...---..---...-------......--------------------.----.....-..----..---------......--------........------................................---.-.-.---..--..-..-..-------------...........................................................--.-----....----.----------...-..-..-.-..-...-...--------.-------..---------------------- A0A2R8QKC8.1/1-128 ----------------------.--------.--------........-----------.......-..-..-.....-.------.------------------.......--.-.-......-.--...---..---...-------......-----MVIHSQKAIHHLATR.LPSS.....C..LGLK..AE-GHLVLH......RFYELFN-........-AKAE-................................KDC.L.G.ALG..FS..M..M..ELELLRVETHHHP...........................................................--.--HGR....PAQE.LFLGDVHTEW...N..E..R.V..H...Y...RPSGYQEP.LQNAMHH..IHPCPVCGLVYRASEQHPPILP A0A2R8QKC8.1/134-313 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