# STOCKHOLM 1.0
#=GF ID   APCDDC
#=GF AC   PF14921.7
#=GF DE   Adenomatosis polyposis coli down-regulated 1
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q8NCL9
#=GF GA   27.00 27.00;
#=GF TC   27.20 28.30;
#=GF NC   26.80 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12384519
#=GF RT   Isolation of a novel human gene, APCDD1, as a direct target of
#=GF RT   the beta-Catenin/T-cell factor 4 complex with probable
#=GF RT   involvement in colorectal carcinogenesis.
#=GF RA   Takahashi M, Fujita M, Furukawa Y, Hamamoto R, Shimokawa T, Miwa
#=GF RA   N, Ogawa M, Nakamura Y;
#=GF RL   Cancer Res. 2002;62:5651-5656.
#=GF RN   [2]
#=GF RM   20393562
#=GF RT   APCDD1 is a novel Wnt inhibitor mutated in hereditary
#=GF RT   hypotrichosis simplex.
#=GF RA   Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A,
#=GF RA   Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA,
#=GF RA   Christiano AM;
#=GF RL   Nature. 2010;464:1043-1047.
#=GF DR   INTERPRO; IPR029405;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The domain is duplicated in most members of this family. APCDD
#=GF CC   is directly regulated by the beta-catenin/Tcf complex, and its
#=GF CC   elevated expression promotes proliferation of colonic epithelial
#=GF CC   cells in vitro and in vivo [1]. APCDD1 has an N-terminal
#=GF CC   signal-peptide and a C-terminal transmembrane region.  The
#=GF CC   domain is rich in cysteines, there being up to 12 such residues,
#=GF CC   a structural motif important for interaction between Wnt ligands
#=GF CC   and their receptors. APCDD1 is expressed in a broad repertoire
#=GF CC   of cell types, indicating that it may regulate a diverse range
#=GF CC   of biological processes controlled by Wnt signalling [2].
#=GF SQ   21
#=GS F1NSX1_CHICK/26-266      AC F1NSX1.2
#=GS H9GLH4_ANOCA/10-250      AC H9GLH4.1
#=GS H3AKK9_LATCH/39-268      AC H3AKK9.1
#=GS F7BE00_XENTR/17-248      AC F7BE00.1
#=GS H3A2X1_LATCH/52-283      AC H3A2X1.1
#=GS APCD1_XENTR/45-276       AC Q6DF34.1
#=GS APCD1_MOUSE/51-282       AC Q3U128.1
#=GS A7SK84_NEMVE/2-228       AC A7SK84.1
#=GS K1R052_CRAGI/78-323      AC K1R052.1
#=GS E9FTE7_DAPPU/1-234       AC E9FTE7.1
#=GS E0VYT8_PEDHC/4-256       AC E0VYT8.1
#=GS K7JF84_NASVI/40-313      AC K7JF84.1
#=GS A0A087ZSD0_APIME/36-307  AC A0A087ZSD0.1
#=GS E2C548_HARSA/37-298      AC E2C548.1
#=GS F4WU93_ACREC/36-287      AC F4WU93.1
#=GS E1ZVB6_CAMFO/37-296      AC E1ZVB6.1
#=GS W5MJB6_LEPOC/85-316      AC W5MJB6.1
#=GS E7F3Y0_DANRE/52-282      AC E7F3Y0.1
#=GS I3JII9_ORENI/63-285      AC I3JII9.1
#=GS F7DNT8_MONDO/41-278      AC F7DNT8.2
#=GS Q66HE0_RAT/32-267        AC Q66HE0.1
F1NSX1_CHICK/26-266                 RCRQQLRHLQDGARIA.ARLPP.RLEGQWVSTGCEVRPGPEFLTRSYLFY..ANRLFKAFQFYYWDPSCREPSYSLVIKGKLRLRQASWITRGATEADYHLHKVGIVFHSQKAMREVASRINQS.SGEGC..SGFL..PPGRAWAPRALYELLS...........AKTE.........................RDCTAALGFAMHELSLVRVERHHQP......LPGLQQSGSS..LVEE.LYLGDIHTDW.LERLHYRPTGYQRPLQSVVHH.MHPCPACGVIYRADEHHPPILP
H9GLH4_ANOCA/10-250                 QCQYQLRHLQDGARIS.ALLPP.RLEGHWVSTGCEVRPGPEFLTRSYVFF..PNRLFKAYQFYYRDPACQDTTYSLVIKGKIRLRQASWITRGATEADYHLHKVGIVFHSQRAMWETVARINQS.SGEHC..SEFL..PAGRTWAPGALYELLS...........AKAE.........................RDCTSGLGFAMHELSLVRVEKYQPP......LFLQQNQGNG..EVEE.LHLGDIHTEW.SERLHYRPTGYQRPLQNAMHH.IHPCPACGIVYRADEHHPPLLP
H3AKK9_LATCH/39-268                 QCQYQLRHLQDGARIS.ALIPP.RLEGHWISTGCEVRPGPEFLTRSYMFY..SNRLFKAFQFFYADNHCHVPTYSLVIKGKIRLRQASWITRGATEADYHLHKVGIVFHGEKRMKEVAVKINQT.....C..IGFL..SSGRSWVSGTVYELLS...........SKTG.........................RDCTAAVGFVMHELSLVRVEKHYYQ.............QGR..VVEE.LFLGDVHTDH.SERMHYRPTGYQRPLQSAMHH.VHPCSACGIIYRSDEYHPPILP
F7BE00_XENTR/17-248                 QCQYQLRHLQDGARIT.ALLPP.NIEGHWISTGCEVRPGPQFLIRSYRFY..PERLFKALQFYYRDPHCRDPSHSLVIKGKVRLRQASWITRGAMEADYQLHKVGVAFHSQEMMSRVRAQMNRT.....C..AGFV..HTGRSWAPGRVYELVS...........TKLG.........................RDCSGAIGFTMHELSLLRLERQYNP...........QHKGA..LVEK.LFLGDIHTDE.SERVHYRPTGYQQPLQSALHH.VHPCPACMEIYRADEHRPPVMP
H3A2X1_LATCH/52-283                 QCHHMLKHLHNGARIT.VQMPP.NIEGHWVSTGCEVRPGPEFITRSYRFY..HNNTFKAYQFYYGDNHCATPIYTLVIRGKLRLRQASWIIRGGTEADYQLHKVKITCHSEVIAEEMRQRINRS.....C..PGFI..QREDPWEPNMSYDLWR...........EESG.........................CDCSRALNFAMHELQLIRVEKQYLH...........HNLDH..LVEE.LFLGDIHTDI.TQRMYYRPSSYQAPLQNAKNH.DHTCIACRIIYRSDEHHPPILP
APCD1_XENTR/45-276                  QCQHMLKHLHNGARVT.VQMPP.NIEGHWVSMGCEVRSGPEFITRSYRFY..NNNTFKAYQYYYGNNHCTNPTYTLVTRGKIRLRQASWIIRGGTEADYQLHNVQVIPHSESVAEKLTWLINHT.....C..PGFV..PGDMPWEPGISYDLWR...........EESG.........................FKCTKALNFAMHELQLIRVEKQYMH...........HNLDH..LVEE.LFLGDIHTDP.TQRMYYRPSSYQPPLQNAKNL.NQNCVACRTILHSDEYHPPILP
APCD1_MOUSE/51-282                  QCHHMLKHLHNGARIT.VQMPP.TIEGHWVSTGCEVRSGPEFMTRSYRFY..NNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHGVQVICHTEAVAEQLSRLVNRT.....C..PGFL..APGGPWVQDVAYDLWQ...........EESN.........................HECTKAVNFAMHELQLIRVEKQYPH...........HSLDH..LVEE.LFLGDIHTDA.TQRVFYRPSSYQPPLQNAKNH.NHACIACRIIFRSDEHHPPILP
A7SK84_NEMVE/2-228                  SCRQIVRHITHYRGIR.SQIRP.DVSGIWTSSRCEARPGPKFLTRFVQIF..SNQTWQADFHFYSDYQCTKPTFTLHVRGAYWLGNEAKDLKGATAAHFNFTTIHIHPHTQAEEVKIVTVMKKS.....C...............PDTLLNIKETPGIGVYSATNAAFSK........................RLCRTTFGISDYEFSVLKINTFKMLS.................SKSDLLYFGEIPTGK.SRRR.YSPTSYQLPLK..RNN.APNCTICMVISTASAGVAPIIP
K1R052_CRAGI/78-323                 .CRQTLSRI..GHLSIEAPQPP.NIAGEWTSQRCEVRPGPEFILRRYYF...QRHHFKLQQYYYKDPGCKRPAYGVVAEGHYRHKRPSWIVQGGTETAYTVHNVSVIPYTSNVARTFTKNAQF......C...................TELANMN........FSTFRKTKILNFPPYAKNSHDASRD.....FDCSFVFNLTFHELQLIRLEIQNHHVYSSIKYFRVVKAKRA..RTEKLLFLGDIHTDV.KQRASYRPTAYQTALRPVFTR...KCHVCSLIANSHDFLPPQLK
E9FTE7_DAPPU/1-234                  ECSSAFKRVQNGERSAHASYPP.DIKGLWVSQECETRPGPEFVLRQYHFE..RDGSFKLLQHFYGDEWCTTPVYTLTAKGQLQMREPSWVVPGAAESEYTLHRVHLVAYSEDVVDEVMQRVNRS.....C..PGYIN.RPWRVRKDDTSLALDE........................................IDCLAAFHAVYHELQLIRTKKNFHL...........HPAVHVQPMQTLLFLGNIHSQL.EQRASYRPTSYQPALVRHDHQESNDCHVCRLVAKSTDKSPPHLH
E0VYT8_PEDHC/4-256                  EVSAM.......DSATTIDQVP.QIEGHWTSQECEIRPGPEFLLRNYIFW..KNNTFRLLQHYYEDESCMIPLYTVIAKGVLTPKESSWVIPSGIDYDYSLTKVTVIPHTTQASEKLSIEKKHK.....CSHSGIKKSYLNTPWKPHLEYTLYNKH........EEESKSSHHHHHHHKKKSVRFKRKKGHKSFSSCLSAMGFHFNELMLIRSQWASVE.............GNK..RNRE.LLLGDIHSRK.QQD..YKPTAFQVPLLDLENA.N.DCVNCQIIAEGTERTPPMLP
K7JF84_NASVI/40-313                 QCDFAVREIMNEDRATVVDESPSRLHAVWISQECEIRAGPEFVIRKYIFF..ENGTFQLMRHYYAEESCSIATHSVTARGQIKILGSSLAAPGASEARYQLDTVHVSPLNRQVAHKLSHRVNVS.....C...GPQ..PRWRPYMAQLIYERAPERGPLT.WHAAPRFNSLHGNSGHHQHQQPQQRRSLEVSRSVDCLSPLGIDFDELKLLRVQSRPTGFRSAAFGGSEK.......PRVE.LFLGELPPDQ.ASKRSHRPTSLQPTALLRTDT.IHNCPICGAISRGTENSPPLLH
A0A087ZSD0_APIME/36-307             RCEMMMKRIDFDDRMTVTDNTPSRLHSTWISQECEIRAGPKYIIRKYSFF..KNDTFLLLQYHYDEESCSIAAYTVIARGSVKILSPSISIPGAAETNVQLDSVYLIPFNRQVAHKFGRIMNAS.....C..GGIE..TKWRPYLPQLIYERSMD.........SPLNMSLHMYDLNSNSLQSRLLRLRKRHT.IACLDSFEIDFTELKLLRVEVKRSSFISKLSRDAIGENKTR..VRIE.LLLGGPARNIHSQRMQPKPNRLQSTSLLRVDT.AIDCPICGSVYRATEYSPPLFH
E2C548_HARSA/37-298                 QCEVTFNEIEKEDRATIVNDSSSRLHATWLSQECEVRAGPEYIIRKYTFF..ENGTFLLLRYHYDDMSCSMPTHTVSIRGSIKLLGPSSVVSGATETKFYINAVHIIPLNRQVAHKFEQKMNTT.....C...GPQ..PRWRPYVSRLIYEQLRQHSATQPWH.SPVYNSLQTYSLSKKRLG............MDCLDTFKIGFGELKLLRVQKRLFL..SKTFGGLSYHG.....RRLE.LLLASPAPNV.SSRRTYKATSLQPTLLVHTNT.TGDCPICGSISRATELSPPLLH
F4WU93_ACREC/36-287                 QCETAIKEIRREDRATIADDSPSRLYSTWLSQE....AGPEYIIRKYTFF..KNGTFLLLRYHYAEESCSIATHTVTIRGSIKLLGSSAVVSGATETKFHVDTINI......VAHKFGHRLNLT.....C...GPQ..PKWRPYVSEVIYEQPRQRSAASSWQ.GPIYNSLQIHSSAKKKLG............MNCLEPFGIEFAELKLLRVQKK.......SFGSSSSNDRYHKLPQFQ.LFLASPTPNI.HSRWNYKPTSLQSTAMIRADT.TSGCPICSSVSRSTEFSPPLLH
E1ZVB6_CAMFO/37-296                 QCEEAIKEIEKENHATIVDDSPSRLQYTWLSQQCETRAGPQYILRKYTFF..KNNTFLLLRYHYADESCSIATHTVIIRGSIKLLKPSSVVSGATETRFHVDAVNILPLTPEITQKFGQKLNLT.....C...GPQ..PKWRLYTSALIYEQPRQHSVRSLWQ.SPKYNSL...QATNKQLG............INCLEPFRIEFTELKLLRVHNKVLL.GHDTFNGTQSYD.....PNFE.LLLANSASNA.HSRRNYKPTSLQSTALYRQDS.TTNCPICSSVFHSTESSPPLLH
W5MJB6_LEPOC/85-316                 QCLSQLRHLQDGARIT.ALIPP.RLEGNWVSTRCEVRPGPEFLTRFYTFY..PSRLFKALQFYYEDAGCRTPAYSLVIRGRLRLRQASWITRGATEAEHHLLKVGIVLHSARARRQLAGRLGSS.....C..PGMLPPAGGRPWAPGRVLELRS...........ARAG.........................RDCLEALGFSMLELGLLRVETRHHA.............HGR..LVQE.LFLGDIHTEW.AQRTHHRPTGYQQPLQNAMHH.VHPCPVCGAVYRSSEHRPPVLP
E7F3Y0_DANRE/52-282                 QCQAQLRHLQNEGRIT.ATIPP.KLEGHWVSSRCEVRPGPEFLTRSYTLYQSPTRLFRALQHYYSDSECQVPTYSLVIRGKLRLRQASWITRGATEAEHHLHKVGMVIHSQKAIHHLATRLPSS.....C..LGL...KAEGHLVLHRFYELFN...........AKAE.........................KDCLGALGFSMMELELLRVETHHHP.............HGR..PAQE.LFLGDVHTEW.NERVHYRPSGYQEPLQNAMHH.IHPCPVCGLVYRASEQHPPILP
I3JII9_ORENI/63-285                 .....YHNIQDRVRIT.ADIPP.QLDGTWVSIRCEVRPGPEFLTRSYTFH..PNRHFQALQHYYTDSSCEDPSYSLLVRGKIRLRQASWITHGATEAEHHLSKVAIVVHSLAAKQRLASRLPST.....C..VGL...SLGR.VVPGKLYELYN...........TRAG.........................RGCLEALGFSMMEMGLVRVETQYHS.............HGG..KVQE.LFLGDIHTDW.TQRTQYKPTGYQQPLQNAMHH.IHPCPVCALVYRSSDQRPPVLP
F7DNT8_MONDO/41-278                 QCQYQLRHLQDGARIT.AMLPP.RLEGHWISTSCEVRPGPEFLTRSYMFF..SNRLFKAYQFYYQDPSCREPLYSLLIKGKIRLRQTSWITRGATEANYHLHKVGIVFHSQSAILEIAERINQT.SGRGC..GKLL..PPGRSWTPGTVYELLS...........AKAE.........................RDCTGALGFAMHELSLIRVERHYKL.........QQMPGNR..VVEE.LYLGDIHTEW.SERLHYRPTGYQHPLQSAMHH.SHPCPACGIIYRSDEHHPPILP
Q66HE0_RAT/32-267                   QCQ...QPVPKGTPIT.VVPLP.LLTGPWISTGCEVRPGPEFLTRSYTFY..SNHLFRAYQFYYRDPSCQQPTHSLLIKGKVHLRQASWVTPGATEADYHLHKVGIVFHSHHALLDIARRLNQTQAGQDC..TGRL..PPGQAWLPGTLYELLS...........SQVP.........................GDCMVALGFSMHELSLLCLQRHIQQ.........QPGLAPH..LVEE.LFLGDVHTDW.AERQHYRPTGYQSPLQSVVHH.TRPCPACSLLAHSNEHRPPVLP
#=GC seq_cons                       QCphtl++lpsssRlT.sphPP.cLcGpWlSppCEVRPGPEFlhRpYpFa..pNppF+AhQaYYsDsuCppPoYoLlI+G+l+LRpuSWlspGATEA-YpLcpVsll.Hoppstcclup+lNpo.....C..sGh...shtRsahsshlYELhp...........scss.........................tDChsAlGFshpELpLlRVEpphh..............tsp..hspE.LFLGDIHT-h.spRhpYRPTuYQpPLpsshcp.spsCPsCullhRusEapPPlLP
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