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0  structures 121  species 0  interactions 519  sequences 14  architectures

Family: BORG_CEP (PF14957)

Summary: Cdc42 effector

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Cdc42 effector Provide feedback

The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton [1]. They may function as negative regulators of Rho GTPase signaling [2].

Literature references

  1. Hirsch DS, Pirone DM, Burbelo PD;, J Biol Chem. 2001;276:875-883.: A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. PUBMED:11035016 EPMC:11035016

  2. Joberty G, Perlungher RR, Macara IG;, Mol Cell Biol. 1999;19:6585-6597.: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. PUBMED:10490598 EPMC:10490598


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR029273

The Rho-type GTPase Cdc42 regulates cell morphology and signal transduction in eukaryotic cells. The Cdc42 effector (CEP) or binder of Rho GTPase (BORG) proteins are involved in the organisation of the actin cytoskeleton [PUBMED:11035016]. They may function as negative regulators of Rho GTPase signaling [PUBMED:10490598].

This family consists of Cdc42 effector proteins, including CEP1-5 from humans.

Domain organisation

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(40)
Full
(519)
Representative proteomes UniProt
(764)
NCBI
(1639)
Meta
(0)
RP15
(57)
RP35
(201)
RP55
(437)
RP75
(523)
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HTML View  View               
PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(40)
Full
(519)
Representative proteomes UniProt
(764)
NCBI
(1639)
Meta
(0)
RP15
(57)
RP35
(201)
RP55
(437)
RP75
(523)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(40)
Full
(519)
Representative proteomes UniProt
(764)
NCBI
(1639)
Meta
(0)
RP15
(57)
RP35
(201)
RP55
(437)
RP75
(523)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:O14613
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R
Number in seed: 40
Number in full: 519
Average length of the domain: 122.50 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 44.59 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.0 25.8
Noise cut-off 24.9 24.7
Model length: 124
Family (HMM) version: 6
Download: download the raw HMM for this family

Species distribution

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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