Summary: HAUS augmin-like complex subunit 2
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HAUS augmin-like complex subunit 2 Provide feedback
This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organising centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis . This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis . This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.
Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M;, Nature. 2003;426:570-574.: Proteomic characterization of the human centrosome by protein correlation profiling. PUBMED:14654843 EPMC:14654843
Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G;, Proc Natl Acad Sci U S A. 2009;106:6998-7003.: The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. PUBMED:19369198 EPMC:19369198
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This family is new in this Pfam release.
|Author:||Coggill P, Hetherington K|
|Number in seed:||7|
|Number in full:||100|
|Average length of the domain:||194.40 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||89.31 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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