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0  structures 52  species 0  interactions 126  sequences 9  architectures

Family: CATSPERD (PF15020)

Summary: Cation channel sperm-associated protein subunit delta

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This is the Wikipedia entry entitled "Cation channels of sperm". More...

Cation channels of sperm Edit Wikipedia article

cation channel, sperm associated 1
Identifiers
Symbol CATSPER1
IUPHAR 388
Entrez 117144
HUGO 17116
OMIM 606389
RefSeq NM_053054
UniProt Q8NEC5
Other data
Locus Chr. 11 q12.1
cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
IUPHAR 389
Entrez 117155
HUGO 18810
OMIM 607249
RefSeq NM_172097
UniProt Q96P55
Other data
Locus Chr. 15 q13-q15
cation channel, sperm associated 3
Identifiers
Symbol CATSPER3
IUPHAR 390
Entrez 347732
HUGO 20819
OMIM 609120
RefSeq NM_178019
UniProt Q86XQ3
Other data
Locus Chr. 5 q31.2
cation channel, sperm associated 4
Identifiers
Symbol CATSPER4
IUPHAR 391
Entrez 378807
HUGO 23220
OMIM 609121
RefSeq NM_198137
UniProt Q7RTX7
Other data
Locus Chr. 1 p35.3

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization.[1] The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

Of the four members of the Catsper family, Catsper1 is found in the primary piece of sperm. Catsper1 plays an important role in evoked Ca2+ entry and regulation of hyperactivation in sperm. Catsper2 is localized in the sperm tail and is responsible for regulation of hyperactivation. Catsper3 and Catsper4 are found in both, the testes and sperm and play an important role in the motility of hyperactivated sperm. Although Catsper seems to play an important role in sperm function, Catspers1-4 null mice have been found to have normal testicular histology, sperm counts and morphology, which is indicative of normal progression of spermatogenesis. [2]

See also

References

  1. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895Freely accessible. PMID 17227845. 
  2. ^ Eun Hwa Park, Do Rim Kim, Ha Young Kim, Seong Kyu Park, and Mun Seog Chang. Panax ginseng induces the expression of CatSper genes and sperm hyper activation. Asian journal of andrology 2014;16(6):845-851.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Cation channel sperm-associated protein subunit delta Provide feedback

The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport [1].

Literature references

  1. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE;, Nat Commun. 2011;2:153.: A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. PUBMED:21224844 EPMC:21224844


This tab holds annotation information from the InterPro database.

InterPro entry IPR028751

CATSPER (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility [PUBMED:11595941]. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore. In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits, including CatSperD (cation channel sperm-associated protein subunit delta) [PUBMED:21224844]. CatSperD is essential for the cation channel function and may play a role in channel assembly or transport.

Gene Ontology

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Domain organisation

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(11)
Full
(126)
Representative proteomes UniProt
(147)
NCBI
(701)
Meta
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RP15
(27)
RP35
(62)
RP55
(86)
RP75
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  Seed
(11)
Full
(126)
Representative proteomes UniProt
(147)
NCBI
(701)
Meta
(0)
RP15
(27)
RP35
(62)
RP55
(86)
RP75
(114)
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  Seed
(11)
Full
(126)
Representative proteomes UniProt
(147)
NCBI
(701)
Meta
(0)
RP15
(27)
RP35
(62)
RP55
(86)
RP75
(114)
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Curation and family details

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Curation View help on the curation process

Seed source: Jackhmmer:Q86XM0
Previous IDs: none
Type: Family
Author: Eberhardt R
Number in seed: 11
Number in full: 126
Average length of the domain: 398.00 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 66.06 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 38.3 29.7
Noise cut-off 21.9 24.3
Model length: 729
Family (HMM) version: 5
Download: download the raw HMM for this family

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