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0  structures 7  species 0  interactions 9  sequences 1  architecture

Family: Leukemia_assc_2 (PF15197)

Summary: Leukemia-associated protein 2

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This is the Wikipedia entry entitled "DLEU2". More...

DLEU2 Edit Wikipedia article

Deleted in lymphocytic leukemia 2 (non-protein coding)
Identifiers
Symbols DLEU2 ; 1B4; BCMSUN; DLB2; LEU2; LINC00022; MIR15AHG; NCRNA00022; RFP2OS; TRIM13OS
External IDs OMIM605766 GeneCards: DLEU2 Gene
Orthologs
Species Human Mouse
Entrez 8847 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NR_002612 n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search [1] n/a

Deleted in lymphocytic leukemia 1 (non-protein coding) is a long non-coding RNA that in humans is encoded by the DLEU2 gene. In humans it is located on chromosome 13q14.[1][2][3] The DLEU2 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.[1]


See also

References

  1. ^ a b Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultstrom AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D (Dec 1997). "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene 15 (20): 2463–73. doi:10.1038/sj.onc.1201643. PMID 9395242. 
  2. ^ Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, Stilgenbauer S, Lichter P (Nov 2000). "BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like". Int J Cancer 88 (5): 692–7. doi:10.1002/1097-0215(20001201)88:5<692::AID-IJC2>3.0.CO;2-3. PMID 11072235. 
  3. ^ "Entrez Gene: DLEU2 deleted in lymphocytic leukemia, 2". 

Further reading

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Leukemia-associated protein 2 Provide feedback

No Pfam abstract.

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This tab holds annotation information from the InterPro database.

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Domain organisation

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Alignments

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(6)
Full
(9)
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(6)
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(1)
RP35
(1)
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  Seed
(6)
Full
(9)
Representative proteomes NCBI
(6)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(1)
Alignment:
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  Seed
(6)
Full
(9)
Representative proteomes NCBI
(6)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(1)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

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Curation and family details

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This family is new in this Pfam release.

Seed source: Jackhmmer:O43262
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 6
Number in full: 9
Average length of the domain: 53.30 aa
Average identity of full alignment: 76 %
Average coverage of the sequence by the domain: 83.92 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 53.8 89.8
Noise cut-off 19.5 18.5
Model length: 53
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

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