Summary: HCF-1 beta-propeller-interacting protein family
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HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus .
This tab holds annotation information from the InterPro database.
InterPro entry IPR029195
VP16 is a component of virion tegument layer that is required for the transcription of the viral immediate-early (IE) genes. In case of human herpes simplex virus (HSV) infection, VP16 binds to HCF-1 (host cell factor 1) and translocates to the nucleus to form a complex with the POU domain protein Oct-1. This complex then directs high level IE gene transcription by the potent activation domain in the C terminus of VP16. HCF-1 provides two functions required by VP16, complex assembly and nuclear targeting [PUBMED:12235138].
This entry represents HPIP (HCF-1 beta-propeller-interacting protein), also known as host cell factor C1 regulator 1 (HCFC1R1), which is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of VP16 into the nucleus [PUBMED:12235138].
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Curation and family details
|Author:||Eberhardt RY, Coggill P, Hetherington K|
|Number in seed:||7|
|Number in full:||60|
|Average length of the domain:||102.50 aa|
|Average identity of full alignment:||56 %|
|Average coverage of the sequence by the domain:||66.01 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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