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0  structures 266  species 0  interactions 373  sequences 6  architectures

Family: DAP (PF15228)

Summary: Death-associated protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "DAP (gene)". More...

DAP (gene) Edit Wikipedia article

DAP
Identifiers
Aliases DAP, death associated protein
External IDs MGI: 1918190 HomoloGene: 3235 GeneCards: DAP
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for DAP
Genomic location for DAP
Band No data available Start 10,679,230 bp[1]
End 10,761,272 bp[1]
RNA expression pattern
PBB GE DAP 201095 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004394
NM_001291963

NM_146057

RefSeq (protein)

NP_001278892
NP_004385

NP_666169

Location (UCSC) Chr 5: 10.68 – 10.76 Mb Chr 5: 31.22 – 31.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.[5][6][7]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112977 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039168 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. PMID 8530096. doi:10.1006/geno.1995.1255. 
  6. ^ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. PMID 7828849. doi:10.1101/gad.9.1.15. 
  7. ^ a b "Entrez Gene: DAP death-associated protein". 

Further reading


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Death-associated protein Provide feedback

No Pfam abstract.

Literature references

  1. Koren I, Reem E, Kimchi A;, Curr Biol. 2010;20:1093-1098.: DAP1, a novel substrate of mTOR, negatively regulates autophagy. PUBMED:20537536 EPMC:20537536


This tab holds annotation information from the InterPro database.

InterPro entry IPR024130

This family includes death-associated protein 1 (DAP1) and death-associated protein-like 1 (DAPL1). DAP1 is involved in mediating interferon-gamma-induced cell death [PUBMED:7828849]. DAPL1 may play a role in the early stages of epithelial differentiation or in apoptosis [PUBMED:15920738].

Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(42)
Full
(373)
Representative proteomes UniProt
(590)
NCBI
(829)
Meta
(0)
RP15
(93)
RP35
(175)
RP55
(307)
RP75
(364)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(42)
Full
(373)
Representative proteomes UniProt
(590)
NCBI
(829)
Meta
(0)
RP15
(93)
RP35
(175)
RP55
(307)
RP75
(364)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(42)
Full
(373)
Representative proteomes UniProt
(590)
NCBI
(829)
Meta
(0)
RP15
(93)
RP35
(175)
RP55
(307)
RP75
(364)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:A0PJW8
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R , Coggill P , Hetherington K
Number in seed: 42
Number in full: 373
Average length of the domain: 86.80 aa
Average identity of full alignment: 36 %
Average coverage of the sequence by the domain: 78.07 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.4 27.1
Noise cut-off 26.3 26.7
Model length: 99
Family (HMM) version: 6
Download: download the raw HMM for this family

Species distribution

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