# STOCKHOLM 1.0
#=GF ID   SOBP
#=GF AC   PF15279.1
#=GF DE   Sine oculis-binding protein
#=GF AU   Eberhardt RY, Coggill P, Hetherington K
#=GF SE   Jackhmmer:Q9Y5P3
#=GF GA   27.00 27.00;
#=GF TC   28.30 27.80;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17618476
#=GF RT   Autosomal recessive mental retardation syndrome with anterior
#=GF RT   maxillary protrusion and strabismus: MRAMS syndrome.
#=GF RA   Basel-Vanagaite L, Rainshtein L, Inbar D, Gothelf D, Hennekam R,
#=GF RA   Straussberg R;
#=GF RL   Am J Med Genet A. 2007;143:1687-1691.
#=GF RN   [2]
#=GF RM   21035105
#=GF RT   SOBP is mutated in syndromic and nonsyndromic intellectual
#=GF RT   disability and is highly expressed in the brain limbic system.
#=GF RA   Birk E, Har-Zahav A, Manzini CM, Pasmanik-Chor M, Kornreich L,
#=GF RA   Walsh CA, Noben-Trauth K, Albin A, Simon AJ, Colleaux L, Morad
#=GF RA   Y, Rainshtein L, Tischfield DJ, Wang P, Magal N, Maya I,
#=GF RA   Shoshani N, Rechavi G, Gothelf D, Maydan G, Shohat M,
#=GF RA   Basel-Vanagaite L;
#=GF RL   Am J Hum Genet. 2010;87:694-700.
#=GF CC   SOBP is associated with syndromic and nonsyndromic intellectual
#=GF CC   disability. It carries a zinc-finger of the zf-C2H2 type at the
#=GF CC   N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh
#=GF CC   motif. The deduced 873-amino acid protein contains an N-terminal
#=GF CC   nuclear localisation signal (NLS), followed by 2 FCS-type zinc
#=GF CC   finger motifs, a proline-rich region (PR1), a putative
#=GF CC   RNA-binding motif region, and a C-terminal NLS embedded in a
#=GF CC   second proline-rich motif.  SOBP is expressed in various human
#=GF CC   tissues, including developing mouse brain at embryonic day 14.
#=GF CC   In postnatal and adult mouse brain SOBP is expressed in all
#=GF CC   neurons, with intense staining in the limbic system. Highest
#=GF CC   expression is in layer V cortical neurons, hippocampus, pyriform
#=GF CC   cortex, dorsomedial nucleus of thalamus, amygdala, and
#=GF CC   hypothalamus. Postnatal expression of SOBP in the limbic system
#=GF CC   corresponds to a time of active synaptogenesis [2]. the family
#=GF CC   is also referred to as Jackson circler, JXC1. In seven affected
#=GF CC   siblings from a consanguineous Israeli Arab family with mental
#=GF CC   retardation, anterior maxillary protrusion, and strabismus
#=GF CC   mutations were found in this protein [1,2].
#=GF SQ   17
#=GS Q7PZA5_ANOGA/218-535  AC Q7PZA5.4
#=GS B0WBD5_CULQU/105-432  AC B0WBD5.1
#=GS Q16NQ8_AEDAE/54-382   AC Q16NQ8.1
#=GS Q95TY2_DROME/278-603  AC Q95TY2.1
#=GS Q28XC2_DROPS/247-588  AC Q28XC2.2
#=GS B4N5Q1_DROWI/245-568  AC B4N5Q1.1
#=GS B4KUF8_DROMO/237-589  AC B4KUF8.1
#=GS E0VHI9_PEDHC/37-370   AC E0VHI9.1
#=GS H9KUQ9_APIME/168-397  AC H9KUQ9.1
#=GS H3HT41_STRPU/158-433  AC H3HT41.1
#=GS E9QB58_DANRE/227-439  AC E9QB58.1
#=GS Q4S6S6_TETNG/231-514  AC Q4S6S6.1
#=GS F6U6M7_MACMU/224-543  AC F6U6M7.1
#=GS H2TT30_TAKRU/227-537  AC H2TT30.1
#=GS B8JKJ8_DANRE/255-571  AC B8JKJ8.1
#=GS G6DC17_DANPL/137-423  AC G6DC17.1
#=GS D6WA41_TRICA/110-340  AC D6WA41.1
Q7PZA5_ANOGA/218-535             TCDWCRHVRHTVSYVDFQDGASQLQFCSDKCLNQYKMQIFCNETQAHLEM....NPHLKEKSTSAGKVTGLR...TLITPELW......MKNCKSCSISP.VSDRSESVSPVPS............LPVRSSPEPSPVLLRSPTPAKKPLISLAPASKLLSKSLQPSTLPTRPSP......................KSSRKRRTGHRPPPGTNASMSSGKRSTVTHQAEYGGSAGASSSINNNNNVTIPNNNLLT.....................................................AVLNIPPQFLPPP......LNLLRAPFFPLNPAQLRFPAGLPNLPNAQPPPAPPPPPPMGPPPSPLAGGPLGGPTGSRPPLPNLLGFGGA.......................APPVTILVPYPI..IIPLPLPIPVPIPV
B0WBD5_CULQU/105-432             TCDWCRHVRHAVSYVDFQDGVTQLQFCSDKCLNQYKMQIFCNETQAHLDM....NPHLKEKSTSAG.........SLITPDLW......LKNCKSRSASP.LSDRSESVSPAPS............LPMRPSPEPSPVMQSSP..AKKPMISVAHPSKLLSKNLQPSAAVNARTVI.....................KSTRKRRPGLRPLQQNTLHNRKNAKVDYGQ..........LTSNNNNNNASVLNNNLPASS...MPKPATVTSANIQDLRAGISLQNLTHSLTPTKFESRESPTTPRPPP....LNIPPQFLQLP.....PNPAMRPPFFPLNPAFR.....FGSPPN..PQAMPPPPPPNMDPNNPQNRH...........QPPLLGFP.........................APPVTILVPYPI..VIPLPLPIPIPIPL
Q16NQ8_AEDAE/54-382              TCDWCRHVRHAVSYVDFQDGVTQLQFCSDKCLNQYKMQIFCNETQAHLDM....NPHLKEKSASTG.........SLITPDLW......LKNCKSRSMSP.ASDRSESVSPTPS..............MHQSPEPSPTMRSPP..SKKPMISVAPASKLLSKTVQIPISRNTA........................KANRKRRPGLRPMQQTVLQNRRSSNLKLDF...........SQTNNNNNSNVLNNNLTSTSSGMLTKPATVTSGSVQDLRNAIPMQKLPHPLTPTKFENRESPTTPRPP.....LNIPHKFLQMP.....PNSAMRPPFFPMNPMFR.....FGSFPN.QPNTMPPPPPIGTPLPNIDLGS.ANRPPGSILGLP...............................VPPVTILVPCPI..VIPLPLPIPIPIPL
Q95TY2_DROME/278-603             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHLDM....HPHLRDQAMD...AGSEA...GLITPDLW......LRNCRSRSASP.ASTL..SVSPGPPP..AP.......AVSRCPDS..PPSH.HP...SKPLISVAPVSKLLAQKSPGPGPGAPPPPPPPV.....QRHLAG.......KLGRRKR...RGISSSLGSETVASLLQKQ.........QQQQAPQQHQAPPTLTADFGGSS.......VPLPPLSPM............PS.MQEAPQQQQAPQVP.PTQ..A........LPRG......PTAIPASYFATPSNGVPMGHPFAGRP........PPPPHHFMHPPPHGMMPRGFGPHFGPPLPPQM...........PE....L.GSLLGA...VPPVTVMVPYPI..IIPLPIPIPVPLPV
Q28XC2_DROPS/247-588             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHLDM....NPHLRDQGLE...AGSEA...GLITPDLW......LRNCRSRSASP.ASTV..SVSPGPPAERSAGA.....TAKRISPSVTPPS..NP...SKPLISVAPVSKLLAQKSPAPAAAVPPPPPPPQ.....QRHHNSLGSGPGLKPGRRKRP.QRGPSSSSGSETVASMLQKQHH.......QQQQ..QQHQ..PTLSADFSGSS.......VPLPPLSPM............PEPAHPHPQQQQPPTVV.PPQ..V........LGRG......PTAIPSSYFAPPPNGHPMGLPFGRHP........AQPPHHFL.PPPHGMMPRGFPPPFGLPMPTQV...........PEHLGAF.AAMMGA...VPPVTVMVPYPI..IIPLPIPIPVPLPV
B4N5Q1_DROWI/245-568             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHLDM....NPHLRDQGLD...AGNEA...ALITPDLW......LRNCRSRSASP.ASTV..SVSPGPI..............KRNSPCATPPS..NP...TKPLISVAPVSKLLALRSPQAAQ.ASQPPPPPQTSLHQQRQQHQNLTS...KSGRRKRL.HRG.GLSAGSETVASLLQKQQ........QHH.......QPSPISADFAGSS.......VPLPPLSPM............PMPEQSAP........P.PPA..AAPPTPTQSLGRG.....CATAIPPSYFATPPNGM.LGHPFGVR...........PPHHFL.PPPPGMLPRGFIPPFG..PPPPF...ATPQM...PEF......GLLGT...APPVTVMVPYPI..IIPLPIPIPVPLPI
B4KUF8_DROMO/237-589             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHLDM....NPHLRDQGLEAAAAGDGA...GLITPDLW......LRNCRSRSASP.ASTI..SVSPGPAAVCIANASASATASKRSSPCHTPPT..HP...SKPLISVAPVSKLLAQKTAP....LTGAPQAPAAPL..QRHHALHSGS...KPGRRKRP.HR..VVGAGSETVASLLQKQQ........QQQQQQQQQPQPPTLSADFAGSS.......VPLPPLSPMQEQQ........PSQQQQPPQQQHPQQLP.PAM...........PCRP......TAGLPAGYFASATNGM.LGHPFGVRPA.......PPPPHPFL.APPPGMLPRGFGAHFG..PPPQM....QPQLQ..PELHGAL.GALLGA...APPVTVMVPYPI..IIPLPIPIPVPLPV
E0VHI9_PEDHC/37-370              TCDWCRHIRHTVNYVDFQDGEHQLQFCSDKCLNQYKMNIFCKETEAHLQL....HPHLQGLGSSGGSNGKGNASVRLITPELW......LRDCRSESPIS.....DRSLSPQDN............NNSSSSPIEIKVVMRPPNENSQLTVKPSPPPSLTPSTLEIT..............................KVDRKERGTHREKSRKTG..................................................SILSKSKRQGRYGSGNNERRGSSLSPRNRENLTPPKPNIFPPSFFPLNGTSLPTMHP....PHPAPPPPPHNGMPPDHGLLKPPF..LPL.GCFPPPPPPPPPPPPPPPTGPRNFQRPGGQIHHRPPLISPPSPSGPTVINKPIRNPLLP..PPRSLLPPVTVLVPYPVALAIPIPLPIPIPIPL
H9KUQ9_APIME/168-397             ICDWCRHIKNPTSYVDLQDGENQLQFCSNRCLNQYKINIFCHETQTHLMLQDINNVSFHDTEKD...........SLITPELW......FRSCQSPLNNSTENICLTDTHFTSS............................LYNNRITETEQNNTEKLIVSNQK.....................................................................................................NIHVKDIKNLQEKEYVNSSGNILKSSYFLNSTSHVID............................QEIPFLSKSNEFSQTKDQKQTNIS.SETSSFKQPNQTELFHSLSSK.............................................LPPVTILVPYPLPIPIPIPIPIPIPVPI
H3HT41_STRPU/158-433             VCDWCRHTRHLQDYINLIDGERRLQFCSPKCMNQYKMESYYKD...........GPSLKRKGTKAGA........SSGSKSNGSAPVSPTLQQQSLSRGNSPDTVSQDASYHDS.................................QTSPSNIPLSGVFQTNSSSSQSL...............................................................................................MGMPQLRPSGVFGVQTVMPQAMSFRQVVPQMPVMQVVGSGGVPLNMVQGLNQSSMAG.........SRKATGRLNPQQWGNIQGIQGVTS..FKKIRPKPQGSSATLPSSTVTSASNSAPFSKHKPRQNTPSSTSAAAAGSSV..............LPPVTVMVPHPV..FIPIPVPIPIPIPV
E9QB58_DANRE/227-439             VCDWCKHIRHTKEYLDFGSGEERLQFCSTKCLNQYKMDVFYREARAALTSSKEEENHPKPAATSENQ........TLLTPDAWESPAKSLSPQTPTASALQRTPVCMRVQTATS...................................................PKSPTGPSQGTP................................................................................................................EQPRPPHMPLPFIR.PPLHAQSLRSPTPNL............PHNPPHPLSPTQRVPFAPPPHYPV.PYLPLHPTFPPQMPPP..................................................WPQPMMMMPYPV..FVPIPIPIPIPIPI
Q4S6S6_TETNG/231-514             VCDWCKHVRHTKEYLDFRSGDERLQFCSTKCLNQYKMDIFYREARAALISSSPSRPSQEG..RADSVVTGQ....KLLTPESWNSSTSVGERHHKSASPK.DPTIIHTSSETPS............ISPSEASFSNSKVHVAGLRT....IQPALHSPAVVVSPKPASLHPPPPTRTT..............................................................................................................LEHQTVPHIPMPFIR.PPLHAQGLKSPLANP............PRHPGPASSPIHRPPHSPYLH.PT..SSSV..NPPGLIHPF.PGAYF.PGL.H.....SPPLS..MMPRGPVAVPPIMNFGIPTFSPL...LPQPTVLVPYPI..IVPLPVPVPIPIPI
F6U6M7_MACMU/224-543             VCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCSTLHPPM..ENKAEGTGV....QLLTPDSWNIPLTDAR.RKAPSPVA.TAG..QSQGPGPS............ASTTVSPSDT...........ANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASIGPP................................................................................LGVPPRSPPMVMTNRGPVPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGP.PPGGPRNLGPTSSPMHRPMLSPHIHPPS..TPTMPGNPPGLLPPPPPGAPL.PSL.P.....FPPVS..MMPNGPMPVPQMMNFGLPSLAPL...VPPPTLLVPYPV..IVPLPVPIPIPIPI
H2TT30_TAKRU/227-537             VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALPGALCNPGHGAGGDSKMEC.SGV....QLLTPESWGTPLTELR.RKAPSPGG.PSS...CSAMTPS............TSSTTSPSDTVAVC.....SPSSSSSVKIPTPRP.....HESPTLPPPPLPN...LHPP................................................................................LGVPSGSPPMVMTPRGPMPLPLFMEHQMLQQMRPPFLR.SSAHPAGPNSPLSNPIIPGIGP.PP.PSRNICPTSSPMHRSLLSPHIHPSS..NPN.....PGMMPPH.PGLPI.PGLPP.....FPPVN..MIPNGRIPLPPVMNIGMPSLAPL...VPPPTLLVPYPI..IVPLPVPIPIPIPI
B8JKJ8_DANRE/255-571             VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALPGGLCNPPLPTS.DTKSESGAGV....QLLTPESWSAPLSELRSRKAPSPVG.......ATIAGPS............GSTSGSPSEAGTVCSSSSSSSSSSSSTKIPTPRP.....HESPSLPPPHPPSISGLHPA................................................................................LGMPPGSPPMVMTPRGPVPFPIFMEHQMMQQMRPPFLR.....PPGPNSPHSNPMIPGIGP.PP.PPRTLCPPSSPMHRPLLSPHLHPSS..TPTLSGNPPGIMPPH.PAAHM.PGL.P.....FPPVN..MMPSGPIPVPPIMNIGMPSLAPL...VPPPTLLVPYPV..IVPLPVPIPIPVPI
G6DC17_DANPL/137-423             TCDWCRHVRHTVAYVDFQDGATQLQFCSDKCLNQYKMHIFCRETQAHLDL....NPHLVNAASSS..........NLITPELW......LKNCRSRSISPTSEGSGTPNDKNDD............TCQRKSPL..............PLITIAPPAKLMNPKPPEDRPVQKSPETKKDLRT...............KMNLRKRRTSKCSTVTSQTVRQRSITPKTQDFRMLS................................PSMDGSSPASCVTSNNPVHSPPHMNQPIPPPFPNPMFG............................MPPPVFMDSNHMNDHRNPM............FQPRVNFMPPPGMHQERPRLFPPLNFHQPINQ............................APPVTVLVPYPV..VIPVPIPIPIPLPL
D6WA41_TRICA/110-340             TCDWCRHVRHTVSYVDSQDGSSQLQFCSDKCLNQYKMHIFWRETRAHLEM....HPHVHGEESSSG.........TLITPDLW......MSKCKSPEVQVSSPSSSPKLGENSQ...............QTSPL..............PLITVAHPSKLMSVQEAEPKRHRN.........................KVQKKKKRNVNLPSCTSTN.................................................KTFSSDMPQDLRIRHTPTDFEANRLNSEDANKTQPEGA..........................SRLSQTQYFCNSEAAAHRKLMDNL.....................................................................VPPPTILVPYPL..ILPLPLPIPIPIPL
#=GC seq_cons                    sCDWC+HlRHsssYVDFQDGtpQLQFCSsKCLNQYKMpIFh+ETQAHLsh....sPHl+stupstt.........sLITP-LW......L+sC+SpSsus.sssh..ssussPu.............s.ptSP..............pshlosu.sopLhs.p...st...sss...........................................................................................hshsshss...............hppph.tp.psPhhs.ss..............hs..........psshhs.sPttt.hhpPa.p.ss.......s.PPh.h..ssPtshh..sh.s......Ps..............................lPPVTlLVPYPl..lIPLPlPIPIPlPl
//