# STOCKHOLM 1.0
#=GF ID   SOBP
#=GF AC   PF15279.7
#=GF DE   Sine oculis-binding protein
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Hetherington K;
#=GF SE   Jackhmmer:Q9Y5P3
#=GF GA   27.10 27.10;
#=GF TC   27.10 27.10;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17618476
#=GF RT   Autosomal recessive mental retardation syndrome with anterior
#=GF RT   maxillary protrusion and strabismus: MRAMS syndrome.
#=GF RA   Basel-Vanagaite L, Rainshtein L, Inbar D, Gothelf D, Hennekam R,
#=GF RA   Straussberg R;
#=GF RL   Am J Med Genet A. 2007;143:1687-1691.
#=GF RN   [2]
#=GF RM   21035105
#=GF RT   SOBP is mutated in syndromic and nonsyndromic intellectual
#=GF RT   disability and is highly expressed in the brain limbic system.
#=GF RA   Birk E, Har-Zahav A, Manzini CM, Pasmanik-Chor M, Kornreich L,
#=GF RA   Walsh CA, Noben-Trauth K, Albin A, Simon AJ, Colleaux L, Morad
#=GF RA   Y, Rainshtein L, Tischfield DJ, Wang P, Magal N, Maya I,
#=GF RA   Shoshani N, Rechavi G, Gothelf D, Maydan G, Shohat M,
#=GF RA   Basel-Vanagaite L;
#=GF RL   Am J Hum Genet. 2010;87:694-700.
#=GF DR   INTERPRO; IPR026092;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   SOBP is associated with syndromic and nonsyndromic intellectual
#=GF CC   disability. It carries a zinc-finger of the zf-C2H2 type at the
#=GF CC   N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh
#=GF CC   motif. The deduced 873-amino acid protein contains an N-terminal
#=GF CC   nuclear localisation signal (NLS), followed by 2 FCS-type zinc
#=GF CC   finger motifs, a proline-rich region (PR1), a putative
#=GF CC   RNA-binding motif region, and a C-terminal NLS embedded in a
#=GF CC   second proline-rich motif.  SOBP is expressed in various human
#=GF CC   tissues, including developing mouse brain at embryonic day 14.
#=GF CC   In postnatal and adult mouse brain SOBP is expressed in all
#=GF CC   neurons, with intense staining in the limbic system. Highest
#=GF CC   expression is in layer V cortical neurons, hippocampus, pyriform
#=GF CC   cortex, dorsomedial nucleus of thalamus, amygdala, and
#=GF CC   hypothalamus. Postnatal expression of SOBP in the limbic system
#=GF CC   corresponds to a time of active synaptogenesis [2]. the family
#=GF CC   is also referred to as Jackson circler, JXC1. In seven affected
#=GF CC   siblings from a consanguineous Israeli Arab family with mental
#=GF CC   retardation, anterior maxillary protrusion, and strabismus
#=GF CC   mutations were found in this protein [1,2].
#=GF SQ   15
#=GS F6U6M7_MACMU/51-370   AC F6U6M7.2
#=GS H3AXM2_LATCH/1-318    AC H3AXM2.1
#=GS E0VHI9_PEDHC/37-370   AC E0VHI9.1
#=GS B4N5Q1_DROWI/245-568  AC B4N5Q1.2
#=GS B4QBP7_DROSI/273-602  AC B4QBP7.1
#=GS B4LIW1_DROVI/240-582  AC B4LIW1.1
#=GS Q7PZA5_ANOGA/218-535  AC Q7PZA5.4
#=GS B0WBD5_CULQU/105-432  AC B0WBD5.1
#=GS Q16NQ8_AEDAE/54-382   AC Q16NQ8.1
#=GS E9GN80_DAPPU/141-450  AC E9GN80.1
#=GS K1PCW3_CRAGI/167-508  AC K1PCW3.1
#=GS W4XN74_STRPU/158-433  AC W4XN74.1
#=GS W5NIN6_LEPOC/228-538  AC W5NIN6.1
#=GS I3KTY8_ORENI/226-537  AC I3KTY8.1
#=GS SOBPA_DANRE/255-571   AC A5X7A0.1
F6U6M7_MACMU/51-370              VCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPA..GLCSTLHPPMENKA.....EGTG........VQLLTPDSWNIPLTDAR.RKAPSPVATAGQSQGPGPS........ASTTVSPSDT....ANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASI.......................GPPLGVPPRSPPMVMTNRGP.......................VPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGPPPG.................GPRNLGPTSSPM.HRPMLSPHIHPPSTPTMPGNPPGLLPPPPPG....A..........P...LPSLPFPPVSMMPNGPMPVPQMMNFGLPSLAPLVPPPTLLVPYPV..IVPLPVPIPIPIPI
H3AXM2_LATCH/1-318               VCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCNTMHPPIEHKSEG.....TGV..........QLLTPDSWNVPLADAR.RKAPSPAATAGLNQGPGPS........ASA..TASPS....DANSSAAKIPTPVPKPLPANESPNVAPVPIQP..P....................ANIVHPVGVPPRSPPMVMTNRGP.......................VPLPIFMEQQMMQQIRPPFIRGPH.APS.PNSPLSNPMIPGIGPPPV.................VPRTIGPSSSPM.HRPMLSPHIHPPSTPTMPGNAPGLLPPPPPGA...P..........F...PPGFPFPPVNMMPNGPVPLPQMVNFGVPSLAPLVPPPTLLVPYPV..IVPLPVPIPFPIPI
E0VHI9_PEDHC/37-370              TCDWCRHIRHTVNYVDFQDGEHQLQFCSDKCLNQYKMNIFCKETEAHL......QLHPHLQGLGSS.....GGSNGKG..NASVRLITPELW...LRDC...RSESPISDRSLSPQ............DNNNSSSSPI.......EIKVVMRPPNENSQLTVKPSPPPSLTPSTLEI...TKVDRK..........ERGTHREKSRKTGSILSKSKRQGRYGSGN.............NERRGSSLSPRNRENL...TPPKPNIFPPSFFPLNGTSLPTMHPPHPAPPP..................PPHNGMPPDHGL.LKPPFLPLGCFPPPPPPPPPPPPPPPTGPRNF...QRPGGQIHHRPP...LISPPSPSGPTV.....INKPIRNPLLPPPRSLLPPVTVLVPYPVALAIPIPLPIPIPIPL
B4N5Q1_DROWI/245-568             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHL......DMNPHLRDQGLD.....AGNE........AALITPDLW...LRNCR.SRSASPAS..TVSVSPGPI........KRNSPCATP.....PSNPTKPLISVAPVSKLLALRSPQAAQASQPPPPP...QTSLHQQRQQHQNLTSKSGRRKRLHRG.GLSAGSETVASLLQKQQ.............QHHQPSPISADFAGSS...VPLPPLSPMPM....PEQSAPPPPAAAPPTPTQSLGR.......GCATAIPPSYFATPPNGM.LGHPFGVR....PPHHFLPPPP...GMLPRGF...I..........P...PFGPPPPFATP.......QMPE..FGLL...GTAPPVTVMVPYPI..IIPLPIPIPVPLPI
B4QBP7_DROSI/273-602             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHL......DMHPHLRDQAMD.....AGSE........AGLITPDLW...LRNCR.SRSASPASTLSVSPGPPPAP......AVSRCPDSPP.....SHHPSKPLISVAPVSKLLAQKCPGPGPGVPPPPPP...PVQRHL..........AGKLGRRKRRGISSSSGSETVASLLQKQQQHHQQ...QQAPQQHQAPPTLTADFGGSS...VPLPPLSPMPSMQEAPQQQQAPQVPPTQVPPRGP.............TAIPASYFATPSNGVPMGHPFAGR.PPPPPHHFMHPPP..HGMMPRGF...G..........P...HFGPPLPPQ..............MPELGSLLGAVPPVTVMVPYPI..IIPLPIPIPVPLPV
B4LIW1_DROVI/240-582             TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHL......DMNPHLRDQGLEA..AAAGDG........AGLITPDLW...LRNCR.SRSASPAS..TISVSPGPAAVCIANASKRSSPCNTP.....PSHPNKPLISVAPVSKLLAQKSPASSSITTGAPPPPLPQLQRHHVH.....AGPKPGRRKRPHRAAG.AAGSETVASLLQKQQ.............QQQQPAPLSADFAGSS...VPLPPLSPMPDQPQ.PQQQHQQ.HPPPQLPQPMGRP..........PAGMPGGYFATPPNGM.LGHPFGAR.AAPPPPHPFLPPP..PGMLPRGF...G..........A...HFGPPPPPQLQP.....QLQPELQGALGALLGAAPPVTVMVPYPI..IIPLPIPIPVPLPI
Q7PZA5_ANOGA/218-535             TCDWCRHVRHTVSYVDFQDGASQLQFCSDKCLNQYKMQIFCNETQAHL......EMNPHLKEKSTS.....AGKVT.....GLRTLITPELW...MKNCK.SCSISPVSDRSESVSPVPSL......PVRSSPEPSPVLLRSPTPAKKPLISLAPASKLLS.KSLQPSTLPTRPS.P...KSSRKR..........RTGHRPPPGTNASMSSGKRST..........................VTHQAEYGGSA.........GASSSINNNNNVTIPNNNLLTAVLNI..................PPQFLPPPLNL..LRAPFFPL..NPAQLRFPAGLPNLPNAQPPPAP.PP..........P..PPMGPPPSPLAGGPLGGPTGSRPPLPNLLGFGGAAPPVTILVPYPI..IIPLPLPIPVPIPV
B0WBD5_CULQU/105-432             TCDWCRHVRHAVSYVDFQDGVTQLQFCSDKCLNQYKMQIFCNETQAHL......DMNPHLKEKSTS.....AG...........SLITPDLW...LKNCK.SRSASPLSDRSESVSPAPSL......PMRPSPEPSPVM..QSSPAKKPMISVAHPSKLLS.KNLQPSAAVNARTVI...KSTRKR..........RPGLRPLQQNTLHNRKNAKVDYGQLTSNN.............NNNNASVLNNNLPASS...MPKPATVTSANIQD.LRAGISLQNLTHSLTPTKFESRESPTTPRPPPLNIPPQFLQLPPNPA.MRPPFFPL....NPAFRFGSPPNPQAMPPP.....P..........P...PNMDPNNPQNR.......HQPP.LLGFP.....APPVTILVPYPI..VIPLPLPIPIPIPL
Q16NQ8_AEDAE/54-382              TCDWCRHVRHAVSYVDFQDGVTQLQFCSDKCLNQYKMQIFCNETQAHL......DMNPHLKEKSAS.....TG...........SLITPDLW...LKNCK.SRSMSPASDRSESVSPTPS........MHQSPEPSPTM..RSPPSKKPMISVAPASKLLSKTVQIPISRNTAK.......ANRKR..........RPGLRPMQQTVLQNRRSSNLKLDFSQTNN..............NNNSNVLNNNLTSTSSGMLTKPATVTSGSVQD.LRNAIPMQKLPHPLTPTKFENRESP.TTPRPPLNIPHKFLQMPPNSA.MRPPFFPM....NPMFRFGSFPNQPNTMPP.....P..........P...PIGTPLPNIDLGS...ANRPPGSILGLP.....VPPVTILVPCPI..VIPLPLPIPIPIPL
E9GN80_DAPPU/141-450             VCDWCKHVRHTVSYVDLHDGQRQLQFCTDKCRNQYKMRLFVAEAS.SLGV..QSCATPGSKGET.S.....PGTSIDLKKQSTGILITPDLW...LSDC...QLDNPINVKLECNEET..........ELASIDSEPE....EQNCEIPLNLVHSSRRSVQPVKRKPNLV.EIPLS....KKGKSH..........RKHHSSS.....HQHKTSIYTRNLIPPP................PPTLPCPATTWPS....FPYPPHMVPSYILQ.SQFLALNRSLK.....P..................PKNPCVRSTDRE.DQISFTPV..IESNKMPSEPVI..EQSSTKVA...T..........PPDERTAEAINELTE.......NKQEINH.TKLLTPEIPPNFVVLRIPY..LIPLPIPVPIPIPL
K1PCW3_CRAGI/167-508             ICDWCKHVRHTVNYVDFQDGETQLQFCSSKCLNQYKMNIFCKETQEHL.....QQISPTTETKSDT.....EGSSD......QQILITPDLW...LSNAK.HKNAKLRRKEAGDTDRELENAEKMESKSDHSRRQSPT....SASSSSDKLPVTNR..SILERMHGRDKSKRSSLRE...SLHERS..........VPRSKSPDSAQ.........PAQNLGIPFVPPHMWGAPTFGMGIPPMGAVPPWFYPGF...MPPGFMPPNMPMEG.LSGVLPSRTETPSATNNKRF............ALSPNYDNESSKNAN.EERGHGRS.SSRPISSARSNTPRSSTPRNTSFSTPT..........P...QSGAPLPNGVG.......MFGQNGMNFS.SYGGFPPLTMILPVPV..PLPLPVPIPLPLPI
W4XN74_STRPU/158-433             VCDWCRHTRHLQDYINLIDGERRLQFCSPKCMNQYKMESYYKDGP.SL........KRKGTKAGASSGSKSNGS..........APVSPTLQ...QQSL..SRGNSPDTVSQDASYHD..........SQTSPSNIPL........SGVFQTNSSSSQSLMGMPQLRPSGVFGVQTV...................MPQAMSFRQVVPQMPVMQVVGSGGVP.....................LNMVQGLNQSSMAGSRKATGRLNPQQWGNIQGIQGVTSFKKIRPKPQGS...........SATLPSSTVTSASNSA....PFSK.......HKPRQNTPSSTSAAAAG.................................................SSVLPPVTVMVPHPV..FIPIPVPIPIPIPV
W5NIN6_LEPOC/228-538             VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQANLPA..GLCNPGHPPMESKP.....ESSN........LQLLTPDSWNTPLGDLR.RKAPSPGTSMAGH.NQAPG........PSGSASASPS.......EATAICSSA.KIPTPGPKPHESPTLPPPVPIP.......................APPMGVPSGSPPMVMTHRGP.......................IPLPFFMDHPMLPQIRSPFLRAPHT.PS.PNSPLPNPIIPGIGPPP..................PPRNLGPTSSPM.HRPMLSPHIHPPTTPTMPGNPPGLMPPHPGAP...M..........P.....GLPFPPVNMMPNGHMPMPQMMNFGVPSLAPLVPPPTLLVPYPV..IVPLPVPIPIPVPI
I3KTY8_ORENI/226-537             VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALPG..ALCNPGHGAGGEGKPE.CSSGV..........QLLTPESWGTPLTDLR.RKAPSPGGPSSTSVL.APST......SSAASPSDTA.........AVCSPSSSSSAKIPTPRPHESPSLPPPPV......................PTLHPPVGVPSGSPPMVMTPRGP.......................MPLPLFMEHQMMQQIRPPFLRTSAHPGG.PNSPLSNPIIPGIGPPP..................PPRTLGPASSPM.HRPLLSPH.....VHPSSNPNPGMIPPHPGI...............P..MPGLPPFPPVNMMPNGPIPLPPMMNFGMPSLAPLVPPPTLLVPYPV..IVPLPVPIPIPIPI
SOBPA_DANRE/255-571              VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALPG..GLCNPPLPTSDTKSE..SGAGV..........QLLTPESWSAPLSELRSRKAPSPVGATIAGPSG..S........TSGSPSEAGT....VCSSSSSSSSSSSSTKIPTPRPHESPSLPPPHPPP...................ISGLHPALGMPPGSPPMVMTPRGP.......................VPFPIFMEHQMMQQMRPPFLRPPG.....PNSPHSNPMIPGIGPPP..................PPRTLCPPSSPM.HRPLLSPHLHPSSTPTLSGNPPGIMPPHPAAH...M..........P.....GLPFPPVNMMPSGPIPVPPIMNIGMPSLAPLVPPPTLLVPYPV..IVPLPVPIPIPVPI
#=GC seq_cons                    sCDWCKHlRHTVsYVDFpDGppQLQFCSsKCLNQYKMpIFs+ETQApL......shsPHhcpcutu.....sGs..........pLITPDLW...Lpss+.p+usSPsosputSsussPu........spsSPssoP.....ssssspshhSsusso+llu.+sptssshsssss.........p...........hssh+s.htssstssshshostu........................ssLssthtts....h..Phhpsssph.s.spsslss.hlPs.sPPP..................PPpslssssssh.h+ssFuPp....ss.ph.sssPs..sshPsuh...s..........P.....GsPhPPhsh.......h....thulsshtshlPPlTlLVPYPl..IIPLPlPIPIPIPl
//