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0  structures 55  species 0  interactions 113  sequences 5  architectures

Family: BMP2K_C (PF15282)

Summary: BMP-2-inducible protein kinase C-terminus

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This is the Wikipedia entry entitled "BMP2K". More...

BMP2K Edit Wikipedia article

BMP2 inducible kinase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BMP2K ; BIKE; HRIHFB2017
External IDs MGI2155456 HomoloGene34134 ChEMBL: 4522 GeneCards: BMP2K Gene
EC number
RNA expression pattern
PBB GE BMP2K 219546 at tn.png
PBB GE BMP2K 59644 at tn.png
PBB GE BMP2K 214716 at tn.png
More reference expression data
Species Human Mouse
Entrez 55589 140780
Ensembl ENSG00000138756 ENSMUSG00000034663
UniProt Q9NSY1 Q91Z96
RefSeq (mRNA) NM_017593 NM_080708
RefSeq (protein) NP_060063 NP_542439
Location (UCSC) Chr 4:
78.78 – 78.92 Mb
Chr 5:
97 – 97.09 Mb
PubMed search [1] [2]

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[1]


This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[1]


Further reading

  • Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression 11 (1-3): 23–45. PMID 11693963. 
  • Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. 
  • Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515. 
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, et al. (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968. 
  • Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, et al. (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BMP-2-inducible protein kinase C-terminus Provide feedback

This family represents the C-terminus of BMP2K and related proteins [1-2].

Literature references

  1. Hoffmann A, Gross G;, Crit Rev Eukaryot Gene Expr. 2001;11:23-45.: BMP signaling pathways in cartilage and bone formation. PUBMED:11693963 EPMC:11693963

  2. Kearns AE, Donohue MM, Sanyal B, Demay MB;, J Biol Chem. 2001;276:42213-42218.: Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. PUBMED:11500515 EPMC:11500515

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR028182

This domain is found at the C terminus of BMP-2-inducible protein kinase (BMP2K) and related proteins. BMP2K may be involved in osteoblast differentiation [PUBMED:11500515, PUBMED:11693963].

Domain organisation

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Curation and family details

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Seed source: Jackhmmer:Q6ZSR9
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 18
Number in full: 113
Average length of the domain: 230.40 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 32.36 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 28.1 42.3
Noise cut-off 24.4 24.3
Model length: 233
Family (HMM) version: 2
Download: download the raw HMM for this family

Species distribution

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