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0  structures 96  species 0  interactions 216  sequences 5  architectures

Family: BMP2K_C (PF15282)

Summary: BMP-2-inducible protein kinase C-terminus

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This is the Wikipedia entry entitled "BMP2K". More...

BMP2K Edit Wikipedia article

Available structures
PDB Ortholog search: PDBe RCSB
Aliases BMP2K, BIKE, HRIHFB2017, BMP2 inducible kinase
External IDs MGI: 2155456 HomoloGene: 34134 GeneCards: BMP2K
RNA expression pattern
PBB GE BMP2K 214716 at tn.png

PBB GE BMP2K 219546 at tn.png

PBB GE BMP2K 59644 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 78.78 – 78.92 Mb Chr 5: 97 – 97.09 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[3]


This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[3]


External links

Further reading

  • Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression. 11 (1-3): 23–45. PMID 11693963. 
  • Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. 
  • Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry. 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515. 
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology. 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968. 
  • Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research. 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BMP-2-inducible protein kinase C-terminus Provide feedback

This family represents the C-terminus of BMP2K and related proteins [1-2].

Literature references

  1. Hoffmann A, Gross G;, Crit Rev Eukaryot Gene Expr. 2001;11:23-45.: BMP signaling pathways in cartilage and bone formation. PUBMED:11693963 EPMC:11693963

  2. Kearns AE, Donohue MM, Sanyal B, Demay MB;, J Biol Chem. 2001;276:42213-42218.: Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. PUBMED:11500515 EPMC:11500515

This tab holds annotation information from the InterPro database.

InterPro entry IPR028182

This domain is found at the C terminus of BMP-2-inducible protein kinase (BMP2K) and related proteins. BMP2K may be involved in osteoblast differentiation [PUBMED:11500515, PUBMED:11693963].

Domain organisation

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Curation and family details

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Seed source: Jackhmmer:Q6ZSR9
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 17
Number in full: 216
Average length of the domain: 191.40 aa
Average identity of full alignment: 40 %
Average coverage of the sequence by the domain: 37.04 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.8 28.8
Noise cut-off 19.8 26.4
Model length: 256
Family (HMM) version: 5
Download: download the raw HMM for this family

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