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0  structures 35  species 0  interactions 79  sequences 4  architectures

Family: BMP2K_C (PF15282)

Summary: BMP-2-inducible protein kinase C-terminus

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This is the Wikipedia entry entitled "BMP2K". More...

BMP2K Edit Wikipedia article

BMP2 inducible kinase
Identifiers
Symbols BMP2K; BIKE
External IDs MGI2155456 HomoloGene34134 ChEMBL: 4522 GeneCards: BMP2K Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE BMP2K 219546 at tn.png
PBB GE BMP2K 59644 at tn.png
PBB GE BMP2K 214716 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55589 140780
Ensembl ENSG00000138756 ENSMUSG00000034663
UniProt Q9NSY1 Q91Z96
RefSeq (mRNA) NM_017593 NM_080708
RefSeq (protein) NP_060063 NP_542439
Location (UCSC) Chr 4:
79.7 – 79.84 Mb
Chr 5:
97 – 97.09 Mb
PubMed search [1] [2]

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[1]

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[1]

References[edit]

Further reading[edit]

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BMP-2-inducible protein kinase C-terminus Provide feedback

This family represents the C-terminus of BMP2K and related proteins [1-2].

Literature references

  1. Hoffmann A, Gross G;, Crit Rev Eukaryot Gene Expr. 2001;11:23-45.: BMP signaling pathways in cartilage and bone formation. PUBMED:11693963 EPMC:11693963

  2. Kearns AE, Donohue MM, Sanyal B, Demay MB;, J Biol Chem. 2001;276:42213-42218.: Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. PUBMED:11500515 EPMC:11500515


Internal database links

External database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(17)
Full
(79)
Representative proteomes NCBI
(64)
Meta
(0)
RP15
(3)
RP35
(5)
RP55
(14)
RP75
(45)
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Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(17)
Full
(79)
Representative proteomes NCBI
(64)
Meta
(0)
RP15
(3)
RP35
(5)
RP55
(14)
RP75
(45)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(17)
Full
(79)
Representative proteomes NCBI
(64)
Meta
(0)
RP15
(3)
RP35
(5)
RP55
(14)
RP75
(45)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

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This family is new in this Pfam release.

Seed source: Jackhmmer:Q6ZSR9
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 17
Number in full: 79
Average length of the domain: 232.80 aa
Average identity of full alignment: 47 %
Average coverage of the sequence by the domain: 35.62 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 54.7
Noise cut-off 26.1 26.1
Model length: 226
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

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