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0  structures 116  species 0  interactions 339  sequences 5  architectures

Family: RNF111_N (PF15303)

Summary: E3 ubiquitin-protein ligase Arkadia N-terminus

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This is the Wikipedia entry entitled "RNF111". More...

RNF111 Edit Wikipedia article

Available structures
PDB Ortholog search: PDBe RCSB
Aliases RNF111, ARK, ring finger protein 111, hRNF111
External IDs MGI: 1934919 HomoloGene: 9741 GeneCards: RNF111
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for RNF111
Genomic location for RNF111
Band n/a Start 58,865,175 bp[1]
End 59,097,419 bp[1]
RNA expression pattern
PBB GE RNF111 218761 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 58.87 – 59.1 Mb Chr 15: 70.43 – 70.5 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[5][6]


The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[6]


RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[7] and Mothers against decapentaplegic homolog 3.[7][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157450 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032217 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature. 410 (6830): 825–30. PMID 11298452. doi:10.1038/35071095. 
  6. ^ a b "Entrez Gene: RNF111 ring finger protein 111". 
  7. ^ a b Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal. 22 (24): 6458–70. PMC 291827Freely accessible. PMID 14657019. doi:10.1093/emboj/cdg632. 
  8. ^ Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone. 44 (1): 53–60. PMID 18950738. doi:10.1016/j.bone.2008.09.013. 

Further reading

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

E3 ubiquitin-protein ligase Arkadia N-terminus Provide feedback

This domain is found at the N-terminus of E3 ubiquitin-protein ligase Arkadia [1].

Literature references

  1. Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D;, Nature. 2001;410:825-830.: Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. PUBMED:11298452 EPMC:11298452

This tab holds annotation information from the InterPro database.

InterPro entry IPR029306

This domain is found at the N terminus of E3 ubiquitin-protein ligase Arkadia. Arkadia plays a role in embryonic development [PUBMED:11298452]. Proteins containing this domain also include protein C18orf25 from humans.

Domain organisation

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Curation and family details

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Seed source: Jackhmmer:Q96B23
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R , Coggill P , Hetherington K
Number in seed: 11
Number in full: 339
Average length of the domain: 243.50 aa
Average identity of full alignment: 47 %
Average coverage of the sequence by the domain: 37.78 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.3 38.4
Noise cut-off 23.6 23.2
Model length: 277
Family (HMM) version: 6
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Species distribution

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