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0  structures 88  species 0  interactions 91  sequences 1  architecture

Family: Chisel (PF15355)

Summary: Stretch-responsive small skeletal muscle X protein, Chisel

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Stretch-responsive small skeletal muscle X protein, Chisel Provide feedback

The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.

Literature references

  1. Patzak D, Zhuchenko O, Lee CC, Wehnert M;, Hum Genet. 1999;105:506-512.: Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein. PUBMED:10598820 EPMC:10598820

  2. Kemp TJ, Sadusky TJ, Simon M, Brown R, Eastwood M, Sassoon DA, Coulton GR;, Genomics. 2001;72:260-271.: Identification of a novel stretch-responsive skeletal muscle gene (Smpx). PUBMED:11401441 EPMC:11401441

  3. Palmer S, Groves N, Schindeler A, Yeoh T, Biben C, Wang CC, Sparrow DB, Barnett L, Jenkins NA, Copeland NG, Koentgen F, Mohun T, Harvey RP;, J Cell Biol. 2001;153:985-998.: The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. PUBMED:11381084 EPMC:11381084

  4. Schindeler A, Lavulo L, Harvey RP;, Exp Cell Res. 2005;307:367-380.: Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway. PUBMED:15893749 EPMC:15893749


This tab holds annotation information from the InterPro database.

InterPro entry IPR029268

Chisel protein plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The X-linked gene Chisel (Csl/Smpx) was first found expressed selectively in human cardiac and skeletal muscle cells [PUBMED:10598820]. It is expressed in embryos in sub-regions of the developing heart corresponding to the future chamber myocardium and in developing skeletal muscles [PUBMED:15893749]. It is a potential target of the cardiac homeodomain transcription factor Nkx2-5 [PUBMED:11381084]. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway [PUBMED:15893749].

Domain organisation

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Alignments

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(7)
Full
(91)
Representative proteomes UniProt
(123)
NCBI
(224)
Meta
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RP15
(10)
RP35
(24)
RP55
(61)
RP75
(87)
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  Seed
(7)
Full
(91)
Representative proteomes UniProt
(123)
NCBI
(224)
Meta
(0)
RP15
(10)
RP35
(24)
RP55
(61)
RP75
(87)
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  Seed
(7)
Full
(91)
Representative proteomes UniProt
(123)
NCBI
(224)
Meta
(0)
RP15
(10)
RP35
(24)
RP55
(61)
RP75
(87)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Trees

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Curation and family details

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Curation View help on the curation process

Seed source: Jcakhmmer:Q9UHP9
Previous IDs: none
Type: Family
Author: Coggill P
Number in seed: 7
Number in full: 91
Average length of the domain: 79.70 aa
Average identity of full alignment: 77 %
Average coverage of the sequence by the domain: 94.64 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 72.7 71.4
Noise cut-off 20.6 20.6
Model length: 86
Family (HMM) version: 5
Download: download the raw HMM for this family

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