# STOCKHOLM 1.0 #=GF ID S100PBPR #=GF AC PF15427.7 #=GF DE S100P-binding protein #=GF AU Coggill P;0000-0001-5731-1588 #=GF GA 27.0 26.4 #=GF NC 25.7 25.4 #=GF TC 38.6 26.4 #=GF SE Jackhmmer:Q96BU1 #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 15632002 #=GF RT Expression of S100P and its novel binding partner S100PBPR in #=GF RT early pancreatic cancer. #=GF RA Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, #=GF RA Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G, #=GF RA Lemoine NR; #=GF RL Am J Pathol. 2005;166:81-92. #=GF RN [2] #=GF RM 16129886 #=GF RT Transition from non-motile behaviour to directed migration #=GF RT during early PGC development in zebrafish. #=GF RA Blaser H, Eisenbeiss S, Neumann M, Reichman-Fried M, Thisse B, #=GF RA Thisse C, Raz E; #=GF RL J Cell Sci. 2005;118:4027-4038. #=GF RN [3] #=GF RM 18089492 #=GF RT Usefulness of S100P in diagnosis of adenocarcinoma of pancreas #=GF RT on fine-needle aspiration biopsy specimens. #=GF RA Deng H, Shi J, Wilkerson M, Meschter S, Dupree W, Lin F; #=GF RL Am J Clin Pathol. 2008;129:81-88. #=GF DR INTERPRO; IPR026097; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC S100PBPR is a family of proteins found in eukaryotes, and #=GF CC localised to cell nuclei where S100P is also present, and the #=GF CC two proteins co-immunoprecipitate. S100P is a member of the S100 #=GF CC family of calcium-binding proteins and there have been several #=GF CC recent reports of its over-expression in pancreatic ductal #=GF CC adenocarcinoma. In situ hybridisation shows S100PBPR transcripts #=GF CC to be found in islet cells but not duct cells of the healthy #=GF CC pancreas. An interaction between S100P and S100PBPR may be #=GF CC involved in early pancreatic cancer. #=GF SQ 30 L9JDF8.1/22-405 -APFS.SS..SLDEDGLDDSLLELSDGEEDDGHFSYTEEEIEELLKDDDLLDEHIPR..E.AGLC.KDDSGRDE..KGERGGHILLDIPQEKNSLYSLGPVTETPDLFKLPQLSTPVGQRPT...PNKPLNKRF..ILDKNLIK.....VT-V.....APFNPTVCDAVLDNDKT.DSSKDTEK.......PSSLGEDT---SYNPDENKLCTESEDISPNNAAWDEPLFSSPLN........................NNFQNTVSDKNIPDSKKPASV.FS....QIS.DHSETPFnTGSSW..RNG.....TSHKSS..CEVRFPVISNSS....NKD...IPDKV...SGKVK.VSERRLGKVTPVLQTKTRTNVTT.F.SQSDLEQQKQIYLRSVIAHIEDPVDS.NQGPLGELCALMDQV....HYT..KNQKWQHPSDLTVRNYARFRQKPLQRCSLTQWVDRNMR.SYHRFQR- Q96BU1.1/22-402 -APFS.WD..SLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSG..E.----.-DDGGHVE..KGERGSQILLDTPREKNSSYSLGPVAETPDLFKLPQLSTSSGHGPA...HTKPLNRRS..VLEKNLIK.....VT-V.....APFNPTVCDALLDKDET.DSSKDTEK.......LSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS-SN........................NNFQQTVSDKNMPDSENPTSV.FS....RIS.DHSETPN.MELSC..RNG.....GSHKSS..CEMRSLVVSTSS....NKQ..dVLNKD...SGKMK.GHERRLGKVIPVLQTKTRTNVPT.F.SQSNLEQQKQLYLRSVIAHIEDPEDT.NQGISGELCALMDQV....HHM..QHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQWVDRNMR.SHHRFQRL G5B5K0.1/21-399 NAPFS.WS..SLDEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNEEEI-..-.EEFL.KDDEPSNEhaNGEKRSQILLETPQEKSSLYSLKPVAETPGLFKLPQLNTTVGHEPI...PAKSLNRHL..VLEKNHIK.....VTVV.....APFDPTVCDPVLDKSKT.DSSKDTEK.......LSSLGEEMREYDLTPNESKVHTESEEISPNISAWDG--ISSPLN........................SNFQQTVSVKNTLDSKKPTPV.FS....QIS.DHSKTPSsTSSSW..KNS.....GSHKLS..CEMRSPVVSSSS....KRD...AFDKD...SGEMK.GREKRTGKVIPVLQTKIRTNVST.F.SQSDLEQQKQIYLRRVFDHIEDPGDS.NQGPSGELYTLMDR-....---..-----QHPSDLTMRNYARFRQKPLQRYSLTQWVERNKR.SHHRFQRL D3ZSX9.1/21-382 NASFS.WG..SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD--------..-.----.---GGHNE..YRARKSQILPHTPQE-NSLYSLGPAAETPGFLKLPQLSPSVGHGPT...PSKSLNRHF..VLEKNLIK.....VTVV.....APFNPTVCDPVLDKDKI.DSSKETEK.......PASLQEQTREDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSPSN........................NNIEQTASDKNIPESKKPTPV.FS....QIS.NHSEVPN.----R..KNS.....GSHKSG..CEVRIPVVSSSS....NRH...AFDKD...SGEAK.G-ERRLGKVIPVLQTRTR----M.F.SQSDLEKQKDIYLSKVIAHIEDPGDS.NQGALGELDALMDQV....-HM..QNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKR.SHHRFQRL G3H934.1/21-385 NASFS.WG..SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD--------..-.----.----GGHE..YGERKCQILPGTRRE-NSLYSLGPAAETPGFFKLPQLSTSVGHGPT...PSKSLNRHF..VLEKNLIK.....VTVV.....APFNPTVCDPVLAKDKV.DSSKDTEN.......PASLGERIGEDDLHPNESKHCTEPEGVSPDNSARDGPLLSSPSN........................NNIEQTASDKNVPESKKPTPV.FS....QIS.NHSEVPN.RGSSW..KNS.....GSHKSG..CEVRIPVVSSSS....NRH...TFDKD...SGEVK.S-ERRLGKVIPVLQTRTR----M.F.SQSDLEKQKDIYLSKVIAHIEDPGDS.NQGTLGELDALMDQV....-HM..QNPDWQHPSDLTTRNYARFRQKPLQRYSLSQWVDRNKR.SHHRFQRL Q9D5K4.1/21-382 NASFP.WG..SLDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD--------..-.----.---GGHNE..YRPRKSQILPDIPQE-NSLYSLGPAAETPGFLKLPQLSTSVGHGPT...PSKSLNRHF..VLEKNLIK.....VTVV.....APFNPTVCDPVLDKDKI.DSSKETEN.......PASLREQTREDDPQPNESKRCTEPEGVSPNTSAWDGPLLSSPSN........................NNIEQTASDKNIPESKKPTPV.FS....QIS.NHSEVPN.----R..KNS.....GSHKSG..CEVRIPVVSSSS....NRH...AFDKD...SGEAK.G-ERRLGKVIPVLQTRTR----M.F.SQSELEKQKDIYLSKVIAHIEDPGDS.NQGTLGELDALMDQV....-HM..QHPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKR.SHHRFQRL F6SKV0.1/31-424 --PVSsWGrfGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSL-..-.GGLR.KDTGGQAE..KLENYSCISFDSPQDINVLCSTGPRAGPASIHNLPQKNIPARHAPI...PTKSPSRHF..VSEKNLLK.....ITLV.....PPFNTTVCDA-FGPKETeSSSKDGSSnanclgtPSSLEKDVNREGHGQNDGKLCTKE--ISSACSVWKGTP---PPK........................AGPPQGPPRANTPICEESVPV.AS....PTL.GPTPRPD.VALSS..GND.....G-HKLG..DTARSPAVQSSS....TKP..vKLDKD...SKKKE.GYERRLGKVIPLQLAKARSKIQT.F.SKTELEQKKQIYLKNVIAHLKNPLES.NQGALGELCALMDQVangeYQK..QNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQWVDRNLR.SHRRFQGL A0A4U5SHA9.1/47-375 NAPFS.WG..SLDEDGLDDSLLELSDG-EDDGHFSFTEEEIQELLKDDDLSNEHLSW..G.GKLL.KDDSRNVE..KEGR-NEILLDAPQEEKSLYSLGPVAETPGLFKLPQLSTSVGHGPT...PTKPLNRRF..ALENNLIK.....ITIV.....APFDPTVCDAVLDKDKT.DTSKDIGK.......PSSLGEELREDELSPNESTLCTESEGIGPSNSVYDRPPLPS-SN........................NNFQQTVSNKNMSDSKKPALLrFS....QIL.DHSETSSnIGSSW..RN-.....GSHKSS..CEMRFPVVSSSS....NKKq.dVPDKD...SGKLK.VREKRLGKVIPVLQAKTRTHVST.F.SPSDLEEQKQSYLRNVIAHIEDPVDS.NQGN-----------....---..--------------------------------------.-------- A0A1A6HBP4.1/35-364 NTSFS.WG..SLDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD--------..-.----.---GGRDE..YGERKCQILPVTPQE-NSLYSLGRAAETPGFFKLPQLSTSVGHGPS...PSKSLNRHF..VLEKNLIK.....VTVV.....APFNPTVCDPVLDKDKI.DSSKDPEK.......PASLGEQPREDDLHPNESKGCTEPEGVSPSNSAWDGPLLSSPSN........................NNIEQTASDKNIPESKKPTPV.FS....QIS.NHSEVPN.RGSSW..KNS.....GSHKSG..CEVRIPVVSSSS....NR-...----D...SGEVR.G-ERRLGKVIPVLQTRAR----M.F.SQADLEKQKDIYLSKVIAHIEDPGDS.NQGTLGELDALMDQV....-HM..QNPDWQHPSDLTTRT-----------------------.-------- L5JRN9.1/1068-1120 NAPFS.WD..SSDEDELDDSLLELSDGEEDDDHLSFTEEEIQELLKDDDQSNKHFS-..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- L5JRN9.1/1121-1368 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....------FCDAVLDKDKT.DTSKDIEK.......PSPLGEEMREDGLSPNKSKLCTESEEISLDNSAWDGPLLPS-PN........................NNFQQTASDKSMPDSKKLKPV.SS....QIL.NHSETPN.MGSSW..RN-.....GSHKSS..CEMKYPVVSSSS....NND...VLDKD...SGKLK.APERRLGKVIPVLQAKTRTNVPT.F.SQSDLEQKKQIYLKNVFAHIEGPVDSnNQGALKELCVLVDQV....HHM..HNQKWPHPSDLTMRNYARFRQNPLERYSLTQWVDKNKR.SHQRFQHL A0A4U5SJY0.1/47-235 NAPFS.WG..SLDEDGLDDSLLELSDG-EDDGHFSFTEEEIQELLKDDDLSNEHLSW..G.GKLL.KDDSRNVE..KEGR-NEILLDAPQEEKSLYSLGPVAETPGLFKLPQLSTSVGHGPT...PTKPLNRRF..ALENNLIK.....ITIV.....APFDPTVCDAVLDKDKT.DTSKDIGK.......PSSLGEELREDELSPNESTLCTESEGIGPRPS------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- A0A4U5SJY0.1/243-312 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..----------SE....KKQ..dVPDKD...SGKLK.VREKRLGKVIPVLQAKTRTHVST.F.SPSDLEEQKQSYLRNVIAHIEDPVDS.NQGN-----------....---..--------------------------------------.-------- F7F7R9.2/34-413 ----S.WAtmGPNEDELDDSLLELSDGEEDDSLFSYTEEEIQELLKDDDSLHDQSSL..G.GGLS.-NAGGQIE..KLGRNSSMSLDSPQDINSLCSLELGAGPASILQLPQVSTPASPSLS...PTKMSSRHS..VPEKSLLK.....VTTV.....PPFKPIVWNGALGKDKM.ESSKDACRnadrlgrPSHMGDDGNKDGTSRNNSKPLTGHEETTCVSSVWEGPL--APSK........................GNSQQMVYGTKKPCRDMPAPL.IS....LTL.EQTGSPS.DGKAS..LGS.....RRSKAS..GARQSPAVPSSS....GKR..iILDKD...SGKMV.AHETRVSKITPLLPTRARSKYPR.F.SQAETEPKMQISLKNGISHLPKSRAL.HQGPLGELYALMDQVtsveYQI..RNSRWQHLSALTMINYPRFRQKPLQRYSLT--------.-------- M7BJQ5.1/108-545 -----.--..CFDDSEPDDSLLEPSDDEQGNSPFNYTEEECREMLADDCLGDDQNSP.gE.SALVtLDVWGQSE..KEVSSNCSWASVPPE-GTETSFRTIDELVSNESLSQTGSSVNTGYFrilENETANSEVegCLNVDCLKsnqviCTLFdcdlqGPLNLSPTDA-DSVDQL.KGDDGLEK.......TGEKASQVIRDDHLQNASKQSIEYDEISSNSLVVEESLVSKEQHrggmdnveklpseikessffydahTKFSTSSPDPACSQSKDKVEN.TA....PVLlLHPKPSN.VVLNQdpSNGlsgtfGSQKED..LSQESTSVEESSe..nLKLnsvVLDQN...CGEAT.TCGKKLGKVIPVPQVEERPKQRIcI.SEAELEQKKYIYIQCVRAHVKNSMDP.TPDALNELYALMDKVasreYRT..QDRRWQHPSDLTMRKYPRFSKKPTQKCSLKQWVSRNLA.HHRRFQD- H3B6V7.1/67-281 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......----------------------------GQESAIAQ-KLESTQD........................ENMQDGDLNSKGHLDKTETLL.QStvpnNLS.NNNQETK.ERLGI..DNA.....EPANSSnsTNLKMGTEASESv.fvKRE...ILGEKhppCDNSQvSLEKKMGKVIPILKPKPRKKAN-.-.KKGEMESRKETYLQCVLSHVTDPTGG.SQGTMSELLTLMDQVasveYKN..QNRLWQHPSDLTARNYPRFSEKPVVKCSLHQWAAEN-R.YHQRFQYL A0A1U7R8X1.1/106-151 -----.--..CFDDSMLDDSLLEPTDSEQEDSSCSYTEEEIQQILADDDLEPEPYT-..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- A0A1U7R8X1.1/387-542 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.----L..ENI.....GSQMED..LGQESSVSEPTDnlklNSV...ILSQS...CGEDT.PSGKKLGKVLPVPQMENRLRRQL.YtSETELEQRKRIYIRCVQAHVRTSRDT.TPGTLEEWYALLSNIa.skNGN..HDQSWKYTLDLTMRNYPRFSKKPTQKYSLNQWVNKNSA.NYRRFQS- A0A402F5V2.1/248-343 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------RRRLIC.I.SEEELWRSKKKYVEDVLAHAKN--SS.IIGPVNELHELMNKVa.seYHF..PEPSYRHPTDLTVRNYAHRTNGEIKKCSLEKWVDRNLR.HFPRFA-- A0A498LRQ7.1/231-338 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-------KVVVPDITKTASKPVV.F.CEEEWERRKKTYVESVKRHMKENGAA.N-GVMSELHTLMNAVa..nYQTgrTGPHWQHPSDLTQRNYLQ-SHPRHQLVSLDEWQKRNNL.SHRRFAK- A0A401RXE5.1/41-136 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-------------ETRQSTRMIW.M.SDEEIERRKNLYLRLVSHHINNG-QR.IQGPMQELLFLMDQVadgeYRN..YSSTWQHPSDLTTRNYCRRNANSFCKLNLYEWANSNGR.-------- A0A1S3SNW8.1/569-683 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.--DQKVVNTRPVQKTAPRP-VVY.D.REEDWQREKWLYVDSVTRHIRENIGA.GEGVMTELLNLMNHVaeqgPGT..NGRQWQHPSDLTRRNYQRRFGNDRTNYTLDEWQNQNYR.NHQRFANL A0A3Q0G457.1/106-151 -----.--..CFDDSMLDDSLLEPTDSEQEDSSCSYTEEEIQQILADDDLEPEPYT-..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- A0A3Q0G457.1/387-476 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.----L..ENI.....GSQMED..LGQESSVSEPTDnlklNSV...ILSQS...CGEDT.PSGKKLGKVLPVPQMENRLRRQL.YtSETELEQRKRIYIRCVQAHVRTSRDT.---------------....---..--------------------------------------.-------- A0A3B3IPD1.1/332-422 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.-KSEWEHQSRQYVYSVTSHMMENQGT.TRGVMTELLDLMTSVs.gqSGA..HGARWQHPADLTCRNYQRRFNKDTPLMSLCDWQRKNQL.TYKRFFK- Q28DZ0.1/442-550 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-KPSQ.LQQKKLGTLPTKPQAACR---PQ.I.SNAELEKNRNIYRDRVMMHLEVH-NI.PGEPNYELATLLNE-....TSR..ENPTWQHPSDYTRRNYYV--RKQPVPCSLNDWVMRNGGpAIERF--- A0A3M0IRE3.1/99-164 -----.-R..CFDDSELDDSLLELSGSEEESSSFDYTEEEIQEILADDSLEAEQQHLagE.SHLS.QSEGDKAE..SSG-------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- A0A3B3HWE0.1/332-421 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.-KSEWEHQSRQYVYSVTSHMMENQGT.T-RVMTELLDLMTSVs.gqSGA..HGARWQHPADLTCRNYQRRFNKDTPLMSLCDWQRKNQL.TYKRFFK- A0A498LVT9.1/71-133 -----.--..-----------------------------------------------..-.----.--------..----------------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---VMSELHTLMNAVa..sYQTgrTGPHWQHPSDLTQRNYLQ-SHPRHQLVSLDEWQKRNNL.SHRRFAK- A0A0Q3U4H3.1/110-174 -----.--..-FDGSESDDALLKLSDSEEGNSPFSFTEKEIQEILADDFVESEQYLT..GkTALS.QDVDGESE..KDESS-----------------------------------------...---------..--------.....----.....-----------------.--------.......--------------------------------------------........................---------------------.--....---.-------.-----..---.....------..------------....---...-----...-----.-----------------------.-.--------------------------.---------------....---..--------------------------------------.-------- //