# STOCKHOLM 1.0 #=GF ID S100PBPR #=GF AC PF15427.7 #=GF DE S100P-binding protein #=GF AU Coggill P;0000-0001-5731-1588 #=GF SE Jackhmmer:Q96BU1 #=GF GA 27.00 26.40; #=GF TC 38.60 26.40; #=GF NC 25.70 25.40; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 15632002 #=GF RT Expression of S100P and its novel binding partner S100PBPR in #=GF RT early pancreatic cancer. #=GF RA Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, #=GF RA Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G, #=GF RA Lemoine NR; #=GF RL Am J Pathol. 2005;166:81-92. #=GF RN [2] #=GF RM 16129886 #=GF RT Transition from non-motile behaviour to directed migration #=GF RT during early PGC development in zebrafish. #=GF RA Blaser H, Eisenbeiss S, Neumann M, Reichman-Fried M, Thisse B, #=GF RA Thisse C, Raz E; #=GF RL J Cell Sci. 2005;118:4027-4038. #=GF RN [3] #=GF RM 18089492 #=GF RT Usefulness of S100P in diagnosis of adenocarcinoma of pancreas #=GF RT on fine-needle aspiration biopsy specimens. #=GF RA Deng H, Shi J, Wilkerson M, Meschter S, Dupree W, Lin F; #=GF RL Am J Clin Pathol. 2008;129:81-88. #=GF DR INTERPRO; IPR026097; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC S100PBPR is a family of proteins found in eukaryotes, and #=GF CC localised to cell nuclei where S100P is also present, and the #=GF CC two proteins co-immunoprecipitate. S100P is a member of the S100 #=GF CC family of calcium-binding proteins and there have been several #=GF CC recent reports of its over-expression in pancreatic ductal #=GF CC adenocarcinoma. In situ hybridisation shows S100PBPR transcripts #=GF CC to be found in islet cells but not duct cells of the healthy #=GF CC pancreas. An interaction between S100P and S100PBPR may be #=GF CC involved in early pancreatic cancer. #=GF SQ 12 #=GS F6SKV0_MONDO/30-424 AC F6SKV0.1 #=GS G3WF27_SARHA/29-413 AC G3WF27.1 #=GS L9JDF8_TUPCH/21-405 AC L9JDF8.1 #=GS G3U198_LOXAF/21-410 AC G3U198.1 #=GS S1PBP_BOVIN/21-408 AC Q3MHH3.1 #=GS E2RNK1_CANLF/21-407 AC E2RNK1.2 #=GS A0A2J8JC26_PANTR/22-402 AC A0A2J8JC26.1 #=GS H0XCQ7_OTOGA/21-407 AC H0XCQ7.1 #=GS D3ZSX9_RAT/21-382 AC D3ZSX9.1 #=GS I3MGM1_ICTTR/22-400 AC I3MGM1.1 #=GS G5B5K0_HETGA/21-399 AC G5B5K0.1 #=GS G1SD82_RABIT/21-404 AC G1SD82.2 F6SKV0_MONDO/30-424 D.PVSSWGRFGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSL..GGLRKDTGGQAE..KLENYSCISFDSPQDI..NVLCSTGPRAGPASIHNLPQKNIPARHAPIPTKSPSRHFVSEKNLLKITLVPPFNTTVCDA.FGPKET...ESSSKDGSSNANCLGTPSSLEKDVNREGHGQNDGKLCTKE..ISSACSVWKGTP...PPKAGPPQGPPRANTPICEESVPVASPTLGPTPRPD.VALSSGNDG.HKLGDTARSPAVQSSS.TKPVKLDKDSKKKEGYERRLGKVIPLQLAKARSKIQTFSKTELEQKKQIYLKNVIAHLKNPLESNQGALGELCALMDQVANGEYQKQNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQWVDRNLRSHRRFQGL G3WF27_SARHA/29-413 NVPISSWGRFGLDEDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSL..GGLRKDTGGDPE..KLGSCSCASFDSPQDI..NVLCSLGPRAGPASIHKLPQISTPASHAPS.....SRHFVPEKSLLKITVVPPFNSTVCDDMLGPKKT...EFSSKDGSSNAYYLG.ISSLKEDVSKEDHGQNDGKLCTKE..ISSTCSVWEGPQ...PHKAGPSQGAPRASGPSCEESVPLASPTLEQSQRQE.VALSSGNGG.HKLGD......ASVHS.TKLVRLDMDSEQKEGYERRLGKVIPLLQARARSKIQTFSQTELEQKKQIYLKNVIAHLKHPLESNQGTLGEFYALMDQVANVEYHMQHQRWQHPSDLTMRNYPRFRQKPLLRYSLTQWVDRNLRSHRRFQGL L9JDF8_TUPCH/21-405 SAPFS.SS..SLDEDGLDDSLLELSDGEEDDGHFSYTEEEIEELLKDDDLLDEHIPREAGLCKDDSGRDE..KGERGGHILLDIPQEK..NSLYSLGPVTETPDLFKLPQLSTPVGQRPTPNKPLNKRFILDKNLIKVT.VAPFNPTVCDAVLDNDKT....DSSKDTEK.......PSSLGEDT...SYNPDENKLCTESEDISPNNAAWDEPLFSSPLNNNFQNTVSDKNIPDSKKPASVFSQISDHSETPFNTGSSWRNGTSHKSSCEVRFPVISNSS.NKD.IPDKVSGKVKVSERRLGKVTPVLQTKTRTNVTTFSQSDLEQQKQIYLRSVIAHIEDPVDSNQGPLGELCALMDQV....HYTKNQKWQHPSDLTVRNYARFRQKPLQRCSLTQWVDRNMRSYHRFQR. G3U198_LOXAF/21-410 SVPFS.WS..SMDEDELDDSLLELSDGEEDDGHFSFTEEEIEMLLQDDDLSDEQSSGRRDLLKDDSGHIE..KGERESQILLDAPQEK..NSLYSLGPVAETPGLFKLPQLSTSIGHGSTPTKPLNRRFALEKNVIKIT.VAPFDPTVYDAVLDKDKT....DSSKDIKK.......PSSLGEELREDGLNTNESKLCTESEVISPTNSAWDGHTFPSPSNNNFQETVSDKNMPDSKKPTPVFSQVLDHSESSSYMGSSYRNGGSHKSSCEVRFPVVSSSE.KKQHVLDKDSGKMKVHERRLGKVIPVLQSKTRTNVPMCSQSDLEQQKEIYLRSVIAHIEDPVDPNQGALGELHALMDQV....HHTQNQKWQHPSDLTMRNYARFRQKSLQRYSLTQWVDRNMGSHHRFQHL S1PBP_BOVIN/21-408 NAPFS.WS..SLDEDELDDSLLELSDG.EDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVE..KGEKGSQIPLDTPQEK..DSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVT.VAPFDPTVCDVALDKDKTYVSEVTSRVTEK.......PSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPS.SNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPN.TGSSRRN.GSYKSSFEMKLP.VSSSS.SKD.VLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQV....HHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRL E2RNK1_CANLF/21-407 NAPFS.WG..SLDEDGLDDSLLDLSEGEEDDGHFSFTEEDIQELLKDDDLSNEHFSWGGGLLKDN.RHVE..KGGKGNEILLDTSQEK..NSLYSLGPVAETPGLLKLPQLSTSVGNGPTPTKPLNRHFALEKNLIKITVVAPFDPTVCDAVLDKDKT....DSSKDTEK.......PSSLGEEMRKGGLSPNENKLCSESEGISPSNSAWDAPPLSSPSDNDFEQTVSDKNMPDSKRPTPVFSQILDHSETPN.TGSSWKN.GSHKSNCEVRFPVVSSSS.NKD.VLDKDSGKLKVNERRLGKVIPVLQAKRRTNVPTFSQSDLEKQKESYLKEVIAHIEHPKDTNQGALGELYALMGQV....HHMQNPKWQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNMRTHHRFQRL A0A2J8JC26_PANTR/22-402 .APFS.WD..CLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGE.....DDGGHVE..KGERGSQILLDTPQEK..NSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT.VAPFNPTVCDALLDKDET....DSSKDTEK.......LSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS.SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPN.MELSCRNGGSHKSSCEMRSLVVSTSS.NKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGVSGELCALMDQV....HHMQHSKWQHPSDLTTRNYAR.RQKHLQRYSLTQWVDRNMRSHHRFQRL H0XCQ7_OTOGA/21-407 NAPFS.WG..SLDDDVLDDSLLELSDGEEDDGHYSYTEEEIEELLKIDEPSSEDHSWEGGLCKDESRHDE..KGERGSQILLDTPQEK..NLLYSLGTVAETSG.FKLPQLSTSIGHGPTPTKPLNRRSAVEKNLIKVT.VAPFNPTVCDAVIDKDQT....DSSKDTEK.......SSSLGEKLKEDGLSSNESKLCTDSEGIRPSNSAWERPSLSSTSNNTFQQTVSDKAVPNSKKPTPAFSQISDHSETPS.VGSSWRNGGSHESSGEMKFPVSSSSNKKKQDVLDKDSGKIKGNERRLGKVIPVLQTKARTNVPTFSQSNLEQQKQIYLRSVIAHIEDPEDSNQDVAGELYTLM.EV....HHMQNPKWQHPSDLTMRNYAR.RQKPLQRYSLTQWVDRNMRSHHRFQRL D3ZSX9_RAT/21-382 NASFS.WG..SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD................GGHNE..YRARKSQILPHTPQE...NSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLDKDKI....DSSKETEK.......PASLQEQTREDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSPSNNNIEQTASDKNIPESKKPTPVFSQISNHSEVPN.....RKNSGSHKSGCEVRIPVVSSSS.NRH.AFDKDSGEAKG.ERRLGKVIPVLQTRTR....MFSQSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQV.....HMQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRL I3MGM1_ICTTR/22-400 .APFS.WG..SLDEDELDDSLLELSDGEEDDDNFNYTEEEIDELLKDDDPSDEHFSLEERLCKDDGRHVE..NGGKGSQVLLETPQEK..NSLYNLRPVAETPGLFKLPQLSTSVGHGPIPTKPLNRRFVLEKNLIKVTVVAPFNPSVCDPVLDKDKI....DSSKDTEK.......PSSLEEGMREDGLNPNESELCTESEEMSPNNSAWDGSLFSSPLNNNFQQTISDKNTPDSKKSTPVFSQISEHSETPN.MGSSWKNGGSQKSSCEMRFPVVSSSS.NRD.ILDKDSGEMKVRERRLGKVIPVLQTKTRTNVSTFSQSDLEQQKQIYLRSVFDHIEDPGDSNQGTSGELYALMNR.............QHPSDLTMRNYARFRQKPLQRYSLNQWVDRNKRSHHRFQRL G5B5K0_HETGA/21-399 NAPFS.WS..SLDEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNEEEIEE..FLKDDEPSNEHANGEKRSQILLETPQEK..SSLYSLKPVAETPGLFKLPQLNTTVGHEPIPAKSLNRHLVLEKNHIKVTVVAPFDPTVCDPVLDKSKT....DSSKDTEK.......LSSLGEEMREYDLTPNESKVHTESEEISPNISAWDG..ISSPLNSNFQQTVSVKNTLDSKKPTPVFSQISDHSKTPSSTSSSWKNSGSHKLSCEMRSPVVSSSS.KRD.AFDKDSGEMKGREKRTGKVIPVLQTKIRTNVSTFSQSDLEQQKQIYLRRVFDHIEDPGDSNQGPSGELYTLMDR.............QHPSDLTMRNYARFRQKPLQRYSLTQWVERNKRSHHRFQRL G1SD82_RABIT/21-404 NASFS.WS..SLDEEELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDPSD...VCGEGLYKDDGGHVE..NGGKGNQILPDTPQEKNSNSLCSLGPVTETPGLFKLPQLNTSVGHGPTPAKPLNRRFALEKNLIKVTIVAPFNPAACDTVREKKKV....NSSKETEK.......PSPTGEEMR.NGLTPNEGEACTESEGISPSNSSWEQPQLSS..NSNVQLTVSGKNLPDCKKPTPVFSQLSDHPETPN.AESPWRNGGSHRSSCEVKFS.VSSSP.NKD.VFDKDSGKVKVHEKRLGKVIPVLQTKTRTNVSTFSQSDLEQQKQIYLRRVIAHIQDPVDSNQGALGELYALMDQV....HHMQNPKRQHPSDLTMRNYARYRQNPPQRYSLTQWVDWNKRSYHRFQHL #=GC seq_cons sAPFS.Wu..SLDEDtLDDSLLELSDGEEDDGHFSaTEEEIpELLKDDD.SsEp.shttsLhKD-us+sE..KGt+sSQILLDTPQEK..NSLYSLGPVAETPulFKLPQLSTSlGHGPoPsKsLNR+FsLEKNLIKVT.VAPFNPTVCDsVLDKDKT....DSSKDTEK.......PSSLGE-hRc-uLsPNEuKLCTESEsISPsNSAW-GP.hSSP.NsNFQQTVSDKNhPDSKKPTPVFSQI.DHSETPs.suSSh+NuGSHKSSCEhRhPVVSSSS.sKp.lLDKDSGKhKspERRLGKVIPVLQoKsRTNVsTFSQSDLEQQKQIYLRsVIAHIEDPhDSNQGsLGELhALMDQV....aHhQN.+WQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNhRSHHRFQRL //