# STOCKHOLM 1.0
#=GF ID   S100PBPR
#=GF AC   PF15427.7
#=GF DE   S100P-binding protein
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q96BU1
#=GF GA   27.00 26.40;
#=GF TC   38.60 26.40;
#=GF NC   25.70 25.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15632002
#=GF RT   Expression of S100P and its novel binding partner S100PBPR in
#=GF RT   early pancreatic cancer.
#=GF RA   Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M,
#=GF RA   Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G,
#=GF RA   Lemoine NR;
#=GF RL   Am J Pathol. 2005;166:81-92.
#=GF RN   [2]
#=GF RM   16129886
#=GF RT   Transition from non-motile behaviour to directed migration
#=GF RT   during early PGC development in zebrafish.
#=GF RA   Blaser H, Eisenbeiss S, Neumann M, Reichman-Fried M, Thisse B,
#=GF RA   Thisse C, Raz E;
#=GF RL   J Cell Sci. 2005;118:4027-4038.
#=GF RN   [3]
#=GF RM   18089492
#=GF RT   Usefulness of S100P in diagnosis of adenocarcinoma of pancreas
#=GF RT   on fine-needle aspiration biopsy specimens.
#=GF RA   Deng H, Shi J, Wilkerson M, Meschter S, Dupree W, Lin F;
#=GF RL   Am J Clin Pathol. 2008;129:81-88.
#=GF DR   INTERPRO; IPR026097;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   S100PBPR is a family of proteins found in eukaryotes, and
#=GF CC   localised to cell nuclei where S100P is also present, and the
#=GF CC   two proteins co-immunoprecipitate. S100P is a member of the S100
#=GF CC   family of calcium-binding proteins and there have been several
#=GF CC   recent reports of its over-expression in pancreatic ductal
#=GF CC   adenocarcinoma. In situ hybridisation shows S100PBPR transcripts
#=GF CC   to be found in islet cells but not duct cells of the healthy
#=GF CC   pancreas. An interaction between S100P and S100PBPR may be
#=GF CC   involved in early pancreatic cancer.
#=GF SQ   12
#=GS F6SKV0_MONDO/30-424      AC F6SKV0.1
#=GS G3WF27_SARHA/29-413      AC G3WF27.1
#=GS L9JDF8_TUPCH/21-405      AC L9JDF8.1
#=GS G3U198_LOXAF/21-410      AC G3U198.1
#=GS S1PBP_BOVIN/21-408       AC Q3MHH3.1
#=GS E2RNK1_CANLF/21-407      AC E2RNK1.2
#=GS A0A2J8JC26_PANTR/22-402  AC A0A2J8JC26.1
#=GS H0XCQ7_OTOGA/21-407      AC H0XCQ7.1
#=GS D3ZSX9_RAT/21-382        AC D3ZSX9.1
#=GS I3MGM1_ICTTR/22-400      AC I3MGM1.1
#=GS G5B5K0_HETGA/21-399      AC G5B5K0.1
#=GS G1SD82_RABIT/21-404      AC G1SD82.2
F6SKV0_MONDO/30-424                 D.PVSSWGRFGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSL..GGLRKDTGGQAE..KLENYSCISFDSPQDI..NVLCSTGPRAGPASIHNLPQKNIPARHAPIPTKSPSRHFVSEKNLLKITLVPPFNTTVCDA.FGPKET...ESSSKDGSSNANCLGTPSSLEKDVNREGHGQNDGKLCTKE..ISSACSVWKGTP...PPKAGPPQGPPRANTPICEESVPVASPTLGPTPRPD.VALSSGNDG.HKLGDTARSPAVQSSS.TKPVKLDKDSKKKEGYERRLGKVIPLQLAKARSKIQTFSKTELEQKKQIYLKNVIAHLKNPLESNQGALGELCALMDQVANGEYQKQNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQWVDRNLRSHRRFQGL
G3WF27_SARHA/29-413                 NVPISSWGRFGLDEDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSL..GGLRKDTGGDPE..KLGSCSCASFDSPQDI..NVLCSLGPRAGPASIHKLPQISTPASHAPS.....SRHFVPEKSLLKITVVPPFNSTVCDDMLGPKKT...EFSSKDGSSNAYYLG.ISSLKEDVSKEDHGQNDGKLCTKE..ISSTCSVWEGPQ...PHKAGPSQGAPRASGPSCEESVPLASPTLEQSQRQE.VALSSGNGG.HKLGD......ASVHS.TKLVRLDMDSEQKEGYERRLGKVIPLLQARARSKIQTFSQTELEQKKQIYLKNVIAHLKHPLESNQGTLGEFYALMDQVANVEYHMQHQRWQHPSDLTMRNYPRFRQKPLLRYSLTQWVDRNLRSHRRFQGL
L9JDF8_TUPCH/21-405                 SAPFS.SS..SLDEDGLDDSLLELSDGEEDDGHFSYTEEEIEELLKDDDLLDEHIPREAGLCKDDSGRDE..KGERGGHILLDIPQEK..NSLYSLGPVTETPDLFKLPQLSTPVGQRPTPNKPLNKRFILDKNLIKVT.VAPFNPTVCDAVLDNDKT....DSSKDTEK.......PSSLGEDT...SYNPDENKLCTESEDISPNNAAWDEPLFSSPLNNNFQNTVSDKNIPDSKKPASVFSQISDHSETPFNTGSSWRNGTSHKSSCEVRFPVISNSS.NKD.IPDKVSGKVKVSERRLGKVTPVLQTKTRTNVTTFSQSDLEQQKQIYLRSVIAHIEDPVDSNQGPLGELCALMDQV....HYTKNQKWQHPSDLTVRNYARFRQKPLQRCSLTQWVDRNMRSYHRFQR.
G3U198_LOXAF/21-410                 SVPFS.WS..SMDEDELDDSLLELSDGEEDDGHFSFTEEEIEMLLQDDDLSDEQSSGRRDLLKDDSGHIE..KGERESQILLDAPQEK..NSLYSLGPVAETPGLFKLPQLSTSIGHGSTPTKPLNRRFALEKNVIKIT.VAPFDPTVYDAVLDKDKT....DSSKDIKK.......PSSLGEELREDGLNTNESKLCTESEVISPTNSAWDGHTFPSPSNNNFQETVSDKNMPDSKKPTPVFSQVLDHSESSSYMGSSYRNGGSHKSSCEVRFPVVSSSE.KKQHVLDKDSGKMKVHERRLGKVIPVLQSKTRTNVPMCSQSDLEQQKEIYLRSVIAHIEDPVDPNQGALGELHALMDQV....HHTQNQKWQHPSDLTMRNYARFRQKSLQRYSLTQWVDRNMGSHHRFQHL
S1PBP_BOVIN/21-408                  NAPFS.WS..SLDEDELDDSLLELSDG.EDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVE..KGEKGSQIPLDTPQEK..DSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVT.VAPFDPTVCDVALDKDKTYVSEVTSRVTEK.......PSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPS.SNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPN.TGSSRRN.GSYKSSFEMKLP.VSSSS.SKD.VLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQV....HHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRL
E2RNK1_CANLF/21-407                 NAPFS.WG..SLDEDGLDDSLLDLSEGEEDDGHFSFTEEDIQELLKDDDLSNEHFSWGGGLLKDN.RHVE..KGGKGNEILLDTSQEK..NSLYSLGPVAETPGLLKLPQLSTSVGNGPTPTKPLNRHFALEKNLIKITVVAPFDPTVCDAVLDKDKT....DSSKDTEK.......PSSLGEEMRKGGLSPNENKLCSESEGISPSNSAWDAPPLSSPSDNDFEQTVSDKNMPDSKRPTPVFSQILDHSETPN.TGSSWKN.GSHKSNCEVRFPVVSSSS.NKD.VLDKDSGKLKVNERRLGKVIPVLQAKRRTNVPTFSQSDLEKQKESYLKEVIAHIEHPKDTNQGALGELYALMGQV....HHMQNPKWQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNMRTHHRFQRL
A0A2J8JC26_PANTR/22-402             .APFS.WD..CLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGE.....DDGGHVE..KGERGSQILLDTPQEK..NSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT.VAPFNPTVCDALLDKDET....DSSKDTEK.......LSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS.SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPN.MELSCRNGGSHKSSCEMRSLVVSTSS.NKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGVSGELCALMDQV....HHMQHSKWQHPSDLTTRNYAR.RQKHLQRYSLTQWVDRNMRSHHRFQRL
H0XCQ7_OTOGA/21-407                 NAPFS.WG..SLDDDVLDDSLLELSDGEEDDGHYSYTEEEIEELLKIDEPSSEDHSWEGGLCKDESRHDE..KGERGSQILLDTPQEK..NLLYSLGTVAETSG.FKLPQLSTSIGHGPTPTKPLNRRSAVEKNLIKVT.VAPFNPTVCDAVIDKDQT....DSSKDTEK.......SSSLGEKLKEDGLSSNESKLCTDSEGIRPSNSAWERPSLSSTSNNTFQQTVSDKAVPNSKKPTPAFSQISDHSETPS.VGSSWRNGGSHESSGEMKFPVSSSSNKKKQDVLDKDSGKIKGNERRLGKVIPVLQTKARTNVPTFSQSNLEQQKQIYLRSVIAHIEDPEDSNQDVAGELYTLM.EV....HHMQNPKWQHPSDLTMRNYAR.RQKPLQRYSLTQWVDRNMRSHHRFQRL
D3ZSX9_RAT/21-382                   NASFS.WG..SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD................GGHNE..YRARKSQILPHTPQE...NSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLDKDKI....DSSKETEK.......PASLQEQTREDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSPSNNNIEQTASDKNIPESKKPTPVFSQISNHSEVPN.....RKNSGSHKSGCEVRIPVVSSSS.NRH.AFDKDSGEAKG.ERRLGKVIPVLQTRTR....MFSQSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQV.....HMQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRL
I3MGM1_ICTTR/22-400                 .APFS.WG..SLDEDELDDSLLELSDGEEDDDNFNYTEEEIDELLKDDDPSDEHFSLEERLCKDDGRHVE..NGGKGSQVLLETPQEK..NSLYNLRPVAETPGLFKLPQLSTSVGHGPIPTKPLNRRFVLEKNLIKVTVVAPFNPSVCDPVLDKDKI....DSSKDTEK.......PSSLEEGMREDGLNPNESELCTESEEMSPNNSAWDGSLFSSPLNNNFQQTISDKNTPDSKKSTPVFSQISEHSETPN.MGSSWKNGGSQKSSCEMRFPVVSSSS.NRD.ILDKDSGEMKVRERRLGKVIPVLQTKTRTNVSTFSQSDLEQQKQIYLRSVFDHIEDPGDSNQGTSGELYALMNR.............QHPSDLTMRNYARFRQKPLQRYSLNQWVDRNKRSHHRFQRL
G5B5K0_HETGA/21-399                 NAPFS.WS..SLDEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNEEEIEE..FLKDDEPSNEHANGEKRSQILLETPQEK..SSLYSLKPVAETPGLFKLPQLNTTVGHEPIPAKSLNRHLVLEKNHIKVTVVAPFDPTVCDPVLDKSKT....DSSKDTEK.......LSSLGEEMREYDLTPNESKVHTESEEISPNISAWDG..ISSPLNSNFQQTVSVKNTLDSKKPTPVFSQISDHSKTPSSTSSSWKNSGSHKLSCEMRSPVVSSSS.KRD.AFDKDSGEMKGREKRTGKVIPVLQTKIRTNVSTFSQSDLEQQKQIYLRRVFDHIEDPGDSNQGPSGELYTLMDR.............QHPSDLTMRNYARFRQKPLQRYSLTQWVERNKRSHHRFQRL
G1SD82_RABIT/21-404                 NASFS.WS..SLDEEELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDPSD...VCGEGLYKDDGGHVE..NGGKGNQILPDTPQEKNSNSLCSLGPVTETPGLFKLPQLNTSVGHGPTPAKPLNRRFALEKNLIKVTIVAPFNPAACDTVREKKKV....NSSKETEK.......PSPTGEEMR.NGLTPNEGEACTESEGISPSNSSWEQPQLSS..NSNVQLTVSGKNLPDCKKPTPVFSQLSDHPETPN.AESPWRNGGSHRSSCEVKFS.VSSSP.NKD.VFDKDSGKVKVHEKRLGKVIPVLQTKTRTNVSTFSQSDLEQQKQIYLRRVIAHIQDPVDSNQGALGELYALMDQV....HHMQNPKRQHPSDLTMRNYARYRQNPPQRYSLTQWVDWNKRSYHRFQHL
#=GC seq_cons                       sAPFS.Wu..SLDEDtLDDSLLELSDGEEDDGHFSaTEEEIpELLKDDD.SsEp.shttsLhKD-us+sE..KGt+sSQILLDTPQEK..NSLYSLGPVAETPulFKLPQLSTSlGHGPoPsKsLNR+FsLEKNLIKVT.VAPFNPTVCDsVLDKDKT....DSSKDTEK.......PSSLGE-hRc-uLsPNEuKLCTESEsISPsNSAW-GP.hSSP.NsNFQQTVSDKNhPDSKKPTPVFSQI.DHSETPs.suSSh+NuGSHKSSCEhRhPVVSSSS.sKp.lLDKDSGKhKspERRLGKVIPVLQoKsRTNVsTFSQSDLEQQKQIYLRsVIAHIEDPhDSNQGsLGELhALMDQV....aHhQN.+WQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNhRSHHRFQRL
//