# STOCKHOLM 1.0
#=GF ID   S100PBPR
#=GF AC   PF15427.1
#=GF DE   S100P-binding protein
#=GF AU   Coggill P
#=GF SE   Jackhmmer:Q96BU1
#=GF GA   27.00 26.40;
#=GF TC   48.50 26.40;
#=GF NC   26.00 25.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15632002
#=GF RT   Expression of S100P and its novel binding partner S100PBPR in
#=GF RT   early pancreatic cancer.
#=GF RA   Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M,
#=GF RA   Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G,
#=GF RA   Lemoine NR;
#=GF RL   Am J Pathol. 2005;166:81-92.
#=GF RN   [2]
#=GF RM   16129886
#=GF RT   Transition from non-motile behaviour to directed migration
#=GF RT   during early PGC development in zebrafish.
#=GF RA   Blaser H, Eisenbeiss S, Neumann M, Reichman-Fried M, Thisse B,
#=GF RA   Thisse C, Raz E;
#=GF RL   J Cell Sci. 2005;118:4027-4038.
#=GF RN   [3]
#=GF RM   18089492
#=GF RT   Usefulness of S100P in diagnosis of adenocarcinoma of pancreas
#=GF RT   on fine-needle aspiration biopsy specimens.
#=GF RA   Deng H, Shi J, Wilkerson M, Meschter S, Dupree W, Lin F;
#=GF RL   Am J Clin Pathol. 2008;129:81-88.
#=GF CC   S100PBPR is a family of proteins found in eukaryotes, and
#=GF CC   localised to cell nuclei where S100P is also present, and the
#=GF CC   two proteins co-immunoprecipitate. S100P is a member of the S100
#=GF CC   family of calcium-binding proteins and there have been several
#=GF CC   recent reports of its over-expression in pancreatic ductal
#=GF CC   adenocarcinoma. In situ hybridisation shows S100PBPR transcripts
#=GF CC   to be found in islet cells but not duct cells of the healthy
#=GF CC   pancreas. An interaction between S100P and S100PBPR may be
#=GF CC   involved in early pancreatic cancer.
#=GF SQ   9
#=GS G3U198_LOXAF/21-410  AC G3U198.1
#=GS E2RNK1_CANFA/21-408  AC E2RNK1.1
#=GS S1PBP_BOVIN/21-408   AC Q3MHH3.1
#=GS F6SKV0_MONDO/29-424  AC F6SKV0.1
#=GS G3WF27_SARHA/29-413  AC G3WF27.1
#=GS D3ZSX9_RAT/21-382    AC D3ZSX9.1
#=GS G5B5K0_HETGA/21-399  AC G5B5K0.1
#=GS H2R1E8_PANTR/21-402  AC H2R1E8.1
#=GS H0XCQ7_OTOGA/21-407  AC H0XCQ7.1
G3U198_LOXAF/21-410             SVPF.SWS..SM..DEDELDDSLLELSDGEEDDGHFSFTEEEIEMLLQDDDLSDEQSSGRRDLLKDD..SGHIEKGERESQILLDAPQEKNSLYSLGPVAETPGLFKLPQLSTSIGHGSTPTKPLNRRFALEKNVIKIT.V.APFDPTVYDAVLDKDKTD....SSKDIKK.......PSSLGEELREDGLNTNESKLCTESEVISPTNSAWDGHTFPSPSNNNFQETVSDKNMPDSKKPTPVFSQVLDHSESSSYMGSSYRNGGSHKSSCEVRFPVVSSSEK.KQHVLDKDSGKMKVHERRLGKVIPVLQSKTRTNVPMCSQSDLEQQKEIYLRSVIAHIEDPVDPNQGALGELHALMDQV....HHTQNQKWQHPSDLTMRNYARFRQKSLQRYSLTQWVDRNMGSHHRFQHL
E2RNK1_CANFA/21-408             NAPF.SWG..SL..DEDGLDDSLLDLSEGEEDDGHFSFTEEDIQELLKDDDLSNEHFSWGG.GLLKD..NRHVEKGGKGNEILLDTSQEKNSLYSLGPVAETPGLLKLPQLSTSVGNGPTPTKPLNRHFALEKNLIKIT.VVAPFDPTVCDAVLDKDKTD....SSKDTEK.......PSSLGEEMRKGGLSPNENKLCSESEGISPSNSAWDAPPLSSPSDNDFEQTVSDKNMPDSKRPTPVFSQILDHSETPN.TGSSWKN.GSHKSNCEVRFPVVSSSSN.KQDVLDKDSGKLKVNERRLGKVIPVLQAKRRTNVPTFSQSDLEKQKESYLKEVIAHIEHPKDTNQGALGELYALMGQV....HHMQNPKWQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNMRTHHRFQRL
S1PBP_BOVIN/21-408              NAPF.SWS..SL..DEDELDDSLLELSDGE.DDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDD..SRNVEKGEKGSQIPLDTPQEKDSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVT.V.APFDPTVCDVALDKDKTYVSEVTSRVTEK.......PSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPS.SNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPN.TGSSRRN.GSYKSSFEMKLPVSSSSSK...DVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQV....HHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRL
F6SKV0_MONDO/29-424             SDPVSSWG..RFGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSLGG..LRKDT..GGQAEKLENYSCISFDSPQDINVLCSTGPRAGPASIHNLPQKNIPARHAPIPTKSPSRHFVSEKNLLKITLV.PPFNTTVCDAFGPKETES....SSKDGSSNANCLGTPSSLEKDVNREGHGQNDGKLCTKE..ISSACSVWKGTPPPK.AG..PPQGPPRANTPICEESVPVASPTLGPTPRPD.VALSSGNDG.HKLGDTARSPAVQSSST.KPVKLDKDSKKKEGYERRLGKVIPLQLAKARSKIQTFSKTELEQKKQIYLKNVIAHLKNPLESNQGALGELCALMDQVANGEYQKQNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQWVDRNLRSHRRFQGL
G3WF27_SARHA/29-413             NVPISSWGRFGL..DEDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNEQSLGG..LRKDT..GGDPEKLGSCSCASFDSPQDINVLCSLGPRAGPASIHKLPQISTPASHAPS.....SRHFVPEKSLLKIT.VVPPFNSTVCDDMLGPKKTE...FSSKDGSSNAY.YLGISSLKEDVSKEDHGQNDGKLCTKE..ISSTCSVWEGPQPHK.AG..PSQGAPRASGPSCEESVPLASPTLEQSQRQE.VALSSGNGG.HKLGD......ASVHST.KLVRLDMDSEQKEGYERRLGKVIPLLQARARSKIQTFSQTELEQKKQIYLKNVIAHLKHPLESNQGTLGEFYALMDQVANVEYHMQHQRWQHPSDLTMRNYPRFRQKPLLRYSLTQWVDRNLRSHRRFQGL
D3ZSX9_RAT/21-382               NASF.SWG..SS..DEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDD................D..GGHNEYRARKSQILPHTPQE.NSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVT.VVAPFNPTVCDPVLDKDKID....SSKETEK.......PASLQEQTREDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSPSNNNIEQTASDKNIPESKKPTPVFSQISNHSEVPN.R....KNSGSHKSGCEVRIPVVSSSSN.R.HAFDKDSGEAKG.ERRLGKVIPVLQTRTR....MFSQSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQV....H.MQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRL
G5B5K0_HETGA/21-399             NAPF.SWS..SL..DEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNEEEIEE..FLKDDEPSNEHANGEKRSQILLETPQEKSSLYSLKPVAETPGLFKLPQLNTTVGHEPIPAKSLNRHLVLEKNHIKVT.VVAPFDPTVCDPVLDKSKTD....SSKDTEK.......LSSLGEEMREYDLTPNESKVHTESEEISPNISAWDGIS.SP.LNSNFQQTVSVKNTLDSKKPTPVFSQISDHSKTPSSTSSSWKNSGSHKLSCEMRSPVVSSSSK.R.DAFDKDSGEMKGREKRTGKVIPVLQTKIRTNVSTFSQSDLEQQKQIYLRRVFDHIEDPGDSNQGPSGELYTLMDR.............QHPSDLTMRNYARFRQKPLQRYSLTQWVERNKRSHHRFQRL
H2R1E8_PANTR/21-402             GAPF.SWD..CL..DEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSG.....EDD..GGHVEKGERGSQILLDTPQEKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT.V.APFNPTVCDALLDKDETD....SSKDTEK.......LSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSS.SNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPN.MELSCRNGGSHKSSCEMRSLVVSTSSN.KQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGVSGELCALMDQV....HHMQHSKWQHPSDLTTRNYAR.RQKHLQRYSLTQWVDRNMRSHHRFQRL
H0XCQ7_OTOGA/21-407             NAPF.SWG..SL..DDDVLDDSLLELSDGEEDDGHYSYTEEEIEELLKIDEPSSEDHSWEGGLCKDE..SRHDEKGERGSQILLDTPQEKNLLYSLGTVAETSG.FKLPQLSTSIGHGPTPTKPLNRRSAVEKNLIKVT.V.APFNPTVCDAVIDKDQTD....SSKDTEK.......SSSLGEKLKEDGLSSNESKLCTDSEGIRPSNSAWERPSLSSTSNNTFQQTVSDKAVPNSKKPTPAFSQISDHSETPS.VGSSWRNGGSHESSGEMKFPVSSSSNKKKQDVLDKDSGKIKGNERRLGKVIPVLQTKARTNVPTFSQSNLEQQKQIYLRSVIAHIEDPEDSNQDVAGELYTLM.EV....HHMQNPKWQHPSDLTMRNYAR.RQKPLQRYSLTQWVDRNMRSHHRFQRL
#=GC seq_cons                   NAPF.SWu..SL..DEDtLDDSLLELS-GEEDDGHFSaTEEEIpELLKDDD.SsEpp.ht..hhcDD..uscsEKGE+tSQILLDTPQEKNSLYSLGPsAETPulaKLPQLSTSlGHGPoPoKsLNR+FsLEKNLIKlT.V.APFsPTVCDslLDKDKTD....SSKDTEK.......sSSLGE-hRE-sLusNESKLCTESEsISPsNSAW-GPshsS.SNssFpQTVSDKNhP-SK+PTPVFSQI.DHSEoPs.su.Sh+NuGSHKSusEhR.PVVSSSSp.K.csLDKDSGKhKGpERRLGKVIPVLQsKsRTNVsTFSQS-LEQQKQIYL+sVIAHIEDPhDSNQGsLGELhALMDQV....HHMQN.+WQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNhRSHHRFQRL
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