Summary: Late endosomal/lysosomal adaptor and MAPK and MTOR activator
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Late endosomal/lysosomal adaptor and MAPK and MTOR activator Provide feedback
LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localise to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.
Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M;, EMBO J. 2009;28:477-489.: The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. PUBMED:19177150 EPMC:19177150
Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M;, J Biol Chem. 2009;284:27315-27326.: A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. PUBMED:19654316 EPMC:19654316
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM;, Cell. 2010;141:290-303.: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. PUBMED:20381137 EPMC:20381137
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Curation and family details
This family is new in this Pfam release.
|Number in seed:||45|
|Number in full:||181|
|Average length of the domain:||75.80 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||44.32 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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