# STOCKHOLM 1.0
#=GF ID   SAS4
#=GF AC   PF15460.1
#=GF DE   Something about silencing, SAS, complex subunit 4
#=GF AU   Coggill P
#=GF SE   Jackhmmer:Q04003
#=GF GA   22.50 22.50;
#=GF TC   22.90 23.20;
#=GF NC   20.90 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10471696
#=GF RT   Identification of SAS4 and SAS5, two genes that regulate
#=GF RT   silencing in Saccharomyces cerevisiae.
#=GF RA   Xu EY, Kim S, Replogle K, Rine J, Rivier DH;
#=GF RL   Genetics. 1999;153:13-23.
#=GF RN   [2]
#=GF RM   11731479
#=GF RT   The yeast SAS (something about silencing) protein complex
#=GF RT   contains a MYST-type putative acetyltransferase and functions
#=GF RT   with chromatin assembly factor ASF1.
#=GF RA   Osada S, Sutton A, Muster N, Brown CE, Yates JR 3rd, Sternglanz
#=GF RA   R, Workman JL;
#=GF RL   Genes Dev. 2001;15:3155-3168.
#=GF RN   [3]
#=GF RM   12626510
#=GF RT   Sas4 and Sas5 are required for the histone acetyltransferase
#=GF RT   activity of Sas2 in  the SAS complex.
#=GF RA   Sutton A, Shia WJ, Band D, Kaufman PD, Osada S, Workman JL,
#=GF RA   Sternglanz R;
#=GF RL   J Biol Chem. 2003;278:16887-16892.
#=GF CC   SAS4 is a family of largely fungal silencing regulators. This
#=GF CC   silencing is mediated by chromatin. SAS4 specifically silences
#=GF CC   the yeast mating-type genes HML and HMR [1]. SAS4 is found to be
#=GF CC   one subunit of a complex, the SAS complex, that interacts with
#=GF CC   chromatin assembly factor Asf1p, and asf1 mutants show silencing
#=GF CC   defects similar to mutants in the SAS complex. Thus,
#=GF CC   ASF1-dependent chromatin-assembly may mediate the role of the
#=GF CC   SAS complex in silencing [2]. Co-expression of Sas2, SAS4, and
#=GF CC   Sas5 in Escherichia coli leads to formation of a stable SAS
#=GF CC   complex that acetylates histones. SAS4 is essential for the
#=GF CC   acetyltransferase activity of Sas2, and Sas5 is also important
#=GF CC   [3].
#=GF SQ   48
#=GS I1S9N9_GIBZE/225-323  AC I1S9N9.1
#=GS F0XS53_GROCL/376-474  AC F0XS53.1
#=GS G4N6E7_MAGO7/302-400  AC G4N6E7.1
#=GS A7UVZ4_NEUCR/289-387  AC A7UVZ4.1
#=GS Q6CCM5_YARLI/191-291  AC Q6CCM5.1
#=GS E7RAW1_PICAD/58-165   AC E7RAW1.1
#=GS F2QPC0_PICP7/87-200   AC F2QPC0.1
#=GS C5DKZ9_LACTC/98-198   AC C5DKZ9.1
#=GS Q6CQC2_KLULA/86-186   AC Q6CQC2.1
#=GS Q750S1_ASHGO/84-183   AC Q750S1.2
#=GS G8JTA8_ERECY/90-188   AC G8JTA8.1
#=GS C5DSY4_ZYGRC/86-186   AC C5DSY4.1
#=GS G0VBR8_NAUCC/118-218  AC G0VBR8.1
#=GS E7LSV2_YEASV/124-224  AC E7LSV2.1
#=GS Q6FU72_CANGA/97-197   AC Q6FU72.1
#=GS G8ZXH3_TORDC/101-201  AC G8ZXH3.1
#=GS G8BRL9_TETPH/141-241  AC G8BRL9.1
#=GS A7TLI0_VANPO/131-231  AC A7TLI0.1
#=GS H2ARA7_KAZAF/106-206  AC H2ARA7.1
#=GS G3AX74_CANTC/88-188   AC G3AX74.1
#=GS A5DMH2_PICGU/189-289  AC A5DMH2.2
#=GS C4Y5Z7_CLAL4/91-191   AC C4Y5Z7.1
#=GS G8YKJ9_PICSO/82-182   AC G8YKJ9.1
#=GS B5RUT9_DEBHA/85-185   AC B5RUT9.1
#=GS A5E7W5_LODEL/110-210  AC A5E7W5.1
#=GS G8BH61_CANPC/85-185   AC G8BH61.1
#=GS Q5A113_CANAL/138-238  AC Q5A113.1
#=GS C5MDI7_CANTT/119-219  AC C5MDI7.1
#=GS A3LZL5_PICST/81-181   AC A3LZL5.2
#=GS H6C7D1_EXODN/293-391  AC H6C7D1.1
#=GS E3RFE4_PYRTT/287-385  AC E3RFE4.1
#=GS A1DBB7_NEOFI/368-466  AC A1DBB7.1
#=GS B6HFN3_PENCW/301-399  AC B6HFN3.1
#=GS Q2URY8_ASPOR/383-482  AC Q2URY8.1
#=GS Q0D1Q9_ASPTN/340-436  AC Q0D1Q9.1
#=GS A2R8M6_ASPNC/326-425  AC A2R8M6.1
#=GS E9D0G4_COCPS/119-217  AC E9D0G4.1
#=GS C4JIL8_UNCRE/78-176   AC C4JIL8.1
#=GS F2RXS7_TRIT1/318-416  AC F2RXS7.1
#=GS C0NG53_AJECG/422-520  AC C0NG53.1
#=GS H0ECM0_GLAL7/260-358  AC H0ECM0.1
#=GS A6SEF6_BOTFB/6-104    AC A6SEF6.1
#=GS B2AY71_PODAN/302-400  AC B2AY71.1
#=GS G0SGP7_CHATD/259-359  AC G0SGP7.1
#=GS Q2HFJ0_CHAGB/261-359  AC Q2HFJ0.1
#=GS G2Q6V6_THIHA/295-393  AC G2Q6V6.1
#=GS G2WTD4_VERDV/352-450  AC G2WTD4.1
#=GS E3Q464_COLGM/313-411  AC E3Q464.1
I1S9N9_GIBZE/225-323             DPLPDKLFQPIHRRAERLERSVRNAEKGRAQHEKDHIIRLLEGLQGH.............DWLRVM.GVSG.VTE.TKKKTFEPARNHFIKGCQAVLDKYRNYVLEEKKRK.LEKD
F0XS53_GROCL/376-474             DPLPDSVFEPHHKRAERLERSIRNSEKGRAQHEKDQIIRLLEGLQGH.............DWLRTM.GVSG.ITE.SKKKSFEPAREHFIKGCRTILKKFRLWSLEEKRLK.LEKD
G4N6E7_MAGO7/302-400             DPLPDALFEPVHKRAERAERSVRNTERGRAQHEKEQIIRLLDGLQGH.............DWLRVM.GVSG.ITE.TKKKEFEEPRQHFIRGCEAILDKFRLWGVEEKRRK.LEKE
A7UVZ4_NEUCR/289-387             DPLPDSLYETAHKKAERLERSIRNSEKGRAQHEKDQIIRLLDALQGH.............DWLRVM.GVSG.ITE.GRKKQFEPAREHFIKGCQAILEKFRRWAAEEKRRK.RKKD
Q6CCM5_YARLI/191-291             DPLPDSLYEGDHKRMERDEKRVQSTERARIMEEKDRLVTQMEQLESG.............EWLRYIAGITK.IHNMGDKEELARKRELTLKECRFMVKSYEQFKEREKQYL.ARKK
E7RAW1_PICAD/58-165              DPLDSKLFEAFHKRGEKEEKRFARDDRNKLLREYQNCMELLGKLGGS.......KAEQKDDRLRFLLETTK.INNVNDPMELDIKFMLTVKELIHFVLNYERVKQLEGEIKSTLDK
F2QPC0_PICP7/87-200              DPLDDKLFLKHHQRAEKSEKKMTNIEKERVFTEYDYYLHCLEQLKTVCQDYEASMVPNQQMMLRITEPFTT.IDDPNDRQEVLMKIQLLIGEITKFTRTFERLRKLELKLK.TLHN
C5DKZ9_LACTC/98-198              DPLEDDLYLTFHKKMQKQETRMLNQDRLQSEGEAERLGVIYEELGTN.............NWVKSLTKTTV.IKNPDDLHELELKRDLTREIIGQMLEKFKDMKTRAMLLP.RSGK
Q6CQC2_KLULA/86-186              DPLSDQLYDNYHKKMLKQETRMMNDESNHSDLEADRLEGILDHLEVA.............SWRLYLPKVTI.VKDLFDEDELHAKKELTQRTIRLMLKKYKYMKHRINIHA.RKQR
Q750S1_ASHGO/84-183              IE.DDDVYESYHRKMFKQETRMINDDKVESENGAERLQHISEALELP.............GWEQVLQQITV.IGDASDAKELESKRKKTQIAIADMLTKFRDMKRRINVHS.RNYR
G8JTA8_ERECY/90-188              D..SDEPYEAYHKKMFKQETRMINDDKIESENEAERLQHIYETLDML.............GWEKVLAQVTV.IRDVDDQKELKTKRELTKLAIQDMLSKFQDMKRRISMQS.RNSR
C5DSY4_ZYGRC/86-186              DTLPDELYWAYHKKMTRHEARMLESDVIQGENEADKLSLWSEKLDLA.............HWQLKLKQITV.IKNSDDEEEMEKKRVLTKETIDSMLARYHTMKKNRSILL.KNNR
G0VBR8_NAUCC/118-218             DPLPDSLYELFHKRMLRHENRMIEQDVIQGENEAERLTLIAEKLDMV.............TWPMTLQKVTK.INDPTDDDEMTRKRAQTIDSIKFMLEKFNLMKRKSIGLT.GIQK
E7LSV2_YEASV/124-224             DLLPDSTYQPYHKKMLKQENRMIQSDIVNGENEADRLSLISDRLGML.............NWEVTLQKVTK.INDPTDENEMETKRYQTKELIDSMLHKFESMXKKSRNLA.RRPA
Q6FU72_CANGA/97-197              SALDDRKYINYHRRMLRQESRMIQLDITHGENEADRLLGVYDKLNMF.............NWQPTLLKVTK.INDPNDEEEMLAKREKTKEYIQTLLNNFDNMKKRTLSLN.KKNA
G8ZXH3_TORDC/101-201             DLLSDALYNSFHKHMLRQETRMLEGDVAEGEAEAERLHLLSEKLDMI.............HWPITLRKVTV.INDPQDEDECSRKRELTKNCITSMLEKFEAMKNRGIMVA.RGFK
G8BRL9_TETPH/141-241             DPLADEKYKPYHKKMLRQENRMIERDASETEREADRLLLLLDKLDMI.............DWKITLAKVTV.INNIEDAEEMNSKRVKTKELIQSMLAKYESTNLRASLFS.KSTR
A7TLI0_VANPO/131-231             DPLSDALYKPYHKKMLKQENRMLERDVNEWETEADRLELLSDKLNML.............DWHISLPKMTV.INDVCDEDEMDRKRELTKEYIRNTLAKYEEMKFQKSLLS.KTCK
H2ARA7_KAZAF/106-206             DPLPDKLYDSFHKKMLRQENRMLEQDVIEGEEEADGLQLIYDKLCMP.............NWPQTLSKVTK.INDQENMEELQLKKKLTRETIKSMLDKFHLMKKNSNMLY.KNRR
G3AX74_CANTC/88-188              DPLSDDKYLPFHRVMTKRETSMNNLDKSKILSEMDGLQTQKSQLLNN.............NWASVLPTITR.INDPGDENELIEKRKLTVAEIDRRLQKFQTWKRRQEELK.QEIK
A5DMH2_PICGU/189-289             EPLPDDLYIGFHRRLKREETVMTNADISRLSSEIDRLKDHLRILRSL.............DWARHLPTITV.VNNRSDSNEMNYKRKLTIGEIERLIANYDSWCRRQDRLR.AENR
C4Y5Z7_CLAL4/91-191              DPLPDQHFETFHRRMKREEKNMTGADRSKMMSEIETLKSQLRLLRQH.............DWMKHLPRITL.VKDPKDRSELQRKRELTEKECLRLLNKYYSWEKRNENLE.NDIR
G8YKJ9_PICSO/82-182              DELPDSVFEGFHRKMTKEEKSMSNVDKMKILSEVDNFRTCLETLKHN.............DWNRHIAEITH.IENPHDISELEEKRKLTIKELKFQLQRYEKWKRGYDSMS.ADFK
B5RUT9_DEBHA/85-185              DILDDSIYETFHKKMKKEERTMVNIDRSRILSEVDNLDLSLQSLNQY.............DWIRHLPNITQ.INDIRDYDELETKKELTIKEIQRILNKFENWKRRQDKLV.NDIK
A5E7W5_LODEL/110-210             DPLPDSLYTIFHRKMRRDEKQMLNDELLRTLSELDTLQHYKQLLDQY.............DWIRHLPQITY.IDNPKDLQDMEWKKQLTLAEIDRLILRQVEWRKKRDEFV.IEVK
G8BH61_CANPC/85-185              DPLPDSKYTIFHRKMKKEETQMLNEEKIKNLVEVDNLNTSLQLLKQY.............DWIRHLPSITK.VNDVMDYEEMERKRELTINEIEILLEKQALWKRKRDKFN.NDAK
Q5A113_CANAL/138-238             DPLPDTTYDIFYRRMKKNEKQMSNEERIKNLWELDTLQSQLERLTQY.............DWIRSLPDITV.IKDMKDYDELERKKELTIKEIERLLQKHENWRKRKEVHS.QEMK
C5MDI7_CANTT/119-219             DPLPDSNYEIFHRKMRRNEKQMTNEEKIKNLWELDTLQSHLEDLNQL.............HWFKALPNITS.IKDVKDYQEMERKRDLTITEIERLLRKHDLWRRRQDIFN.TDVK
A3LZL5_PICST/81-181              DPLPDKCYDVFHRKMKKEEKVMTNEDRLRILSEVDNLQTQLALLNQY.............DWIRHLPGIAF.INDPRDYEELEQKKLLTISEIERLIRKHENWRRRLDAIT.AAIK
H6C7D1_EXODN/293-391             DPLGEEVYSKIHSKAERHEKQMKNSDRERAQHEKYQLEKLLDDLRGP.............DWLKTL.GISG.VTD.TEKRRYEPKRLLFIRETQALIDKFKRWKEEEKRRK.LEKE
E3RFE4_PYRTT/287-385             DPLADAVYFTQHRRAERKEKQLRNIEKERAMHEKVQLERLLDGLQGP.............DWLKVM.GITG.VTD.GERKDWEAKRTYFVKEVEALVDKFRVWKEEEKRLR.AEKE
A1DBB7_NEOFI/368-466             DPLNEGYYFRAHRRMERQEKQLRNIERERAQHEKMQLERLLDELKGH.............DWLRVM.GITG.VQE.HEKKLYEPKRDYFMKEIAGLIEKFQIWKEEEKRRK.LDKD
B6HFN3_PENCW/301-399             DPLSEETYFRAHRKFERQEKQLRNIERNRAQHEQQVLERLLDELRGH.............DWLRMM.GLTG.VHE.SDKKLYEPKRDILIQELVTLVNKFQAWKDEERRRK.LEKE
Q2URY8_ASPOR/383-482             DPLNEGTYFKAHRRNERQEKQLRNIERERAQHEKQQLDRLLDELQNH.............DWLRVM.GITGLLSD.QEKKQYEPKRDYFIKEISALIQKFKIWKEEEKRRK.VEKE
Q0D1Q9_ASPTN/340-436             DPLSEATYFRAHRRNERQEKQLRNIERDRAQHEKQQLDRLLDELQSQ.............DWPRVM.GIGT.LTDHEEKKQYETKRAFFVKEIAASALEIQNL...ERRRK.ATQD
A2R8M6_ASPNC/326-425             DPLSEETYFRPHRRNERQEKQLRNIERDRAQHEKQNLDRLLDELQGH.............DWLRVM.GITGLISD.PERKHFESKRTYFIREISAVLQKFKIWREEEKRRK.SEKD
E9D0G4_COCPS/119-217             DPLLNGTYFKAHRRIERKETQLRNIEKERAQHEKIQVDRLLSALRGA.............DWLRVM.GVSG.IAE.SEKHLYEPKRTYFIMELAALLDKFKIWKQKEKRRK.LKQQ
C4JIL8_UNCRE/78-176              DPLSNGVFFKAHRKNERKETQLRNIEKERAQHQQIQLDRLLVALQGA.............DWVRVM.GISG.ITE.SEKKLYEPKRAYFIMELTALLEKFKFWKEKEKRRK.AEQQ
F2RXS7_TRIT1/318-416             DPLDEDTFFKAHRRLERQEKQLRNLEKERAQYEKTQLDHLLGELQGH.............DWLRVM.GING.VTD.SEKKLYEPKRDYFVGEVTALLEKFRAWKEEEKRRR.IERE
C0NG53_AJECG/422-520             DPLDDDVYFKAHRRIERQEKQLRNIEKERAQHEKVQLDRLLDELQGH.............DWLRVM.GISG.ITE.TEKKLYEPKRAYFIKEVSALIEKFRLWKEEERRRK.MEKD
H0ECM0_GLAL7/260-358             DPLSDEYFEKLHKKPERQEKAIRNSDKGRAQHEKDQIVRLLEGLQGH.............DWLKLM.GVNG.VTD.SRRREYEPAREHFIKGCEAILEKFRNWKDEEKRRK.LEKE
A6SEF6_BOTFB/6-104               DPLFEEHFKTLHNGPDGQEKAVRNADKSRAQHERDSVIRLMEGLQGP.............DWLKTL.GVSG.ITE.GRKKEFESARQYFIKGCESILEKFRIWKDDEKQRK.LKKE
B2AY71_PODAN/302-400             DPLPDSYYEPIHKKEEKQERSVRNTEKIRAQHERDQVIRLLDGLQGP.............DWLRIM.GVSG.ITE.SKKKTFEPAREYFVKGCESILDKFRRWTAEEKRRK.REKE
G0SGP7_CHATD/259-359             DPLPDSLFELPHKRAERQERSIRNTEKGRAKHEKEQVVRLLEGLQGP.............EWLRIL.GVHGPTTE.AKRRQYEPAREYFISGCQAILDKFKRWTAEEKRRKQMEKD
Q2HFJ0_CHAGB/261-359             DPLPDSLFAPAHKKAERSERSVRNTEIGRAQHERDQVARLLNGLRGH.............DWLRVL.GVSG.VTE.TKKRAFEPARDHFIRGCEGILDKFRRYTREEKRRR.AEML
G2Q6V6_THIHA/295-393             DPLPDTLYSPAHRKAERLERSIRNTEKGRAQHEKDQIMRLLDGLQGH.............DWLRVM.GVNG.ITE.SKKRAFEPARQHFIRGCENILSKFRRWAREEKRRR.AEML
G2WTD4_VERDV/352-450             SALPDALYLPIHKRAERLERSIRNTEKGRAQHEKDQIVRLLEGLQGH.............DWLRIM.GVSG.VTE.SKKKSFEPARRHFIKGCQAIIDKFRQWAQEEKRRK.AEKE
E3Q464_COLGM/313-411             DPLPDATFVSAHKRAERLEKSIRNTERGRAQHEKDQIARLLDGLQGH.............DWLRVM.GVSG.VTE.TRKKQFEPARQHFVKGCQAILDKFRQWSLEEKRRK.AEKD
#=GC seq_cons                    DPLsDshYpshH++hcRpE+phpNt-+tRuppEt-pLpclL-tLpsh.............DWlRsh.slTs.Is-.s-cc-hEsKRphhlcplpslLcKFcpW+ccccchp.tcpc
//