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Secretogranin-3 Provide feedback
Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells . SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells . Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion .
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T;, Mol Biol Cell. 2002;13:3388-3399.: Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. PUBMED:12388744 EPMC:12388744
Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T;, J Biol Chem. 2004;279:3627-3634.: Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. PUBMED:14597614 EPMC:14597614
Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K;, J Clin Endocrinol Metab. 2007;92:1145-1154.: Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. PUBMED:17200173 EPMC:17200173
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|Number in seed:||8|
|Number in full:||53|
|Average length of the domain:||404.80 aa|
|Average identity of full alignment:||72 %|
|Average coverage of the sequence by the domain:||96.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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