Summary: Exocyst complex component Sec5
Exocyst complex component Sec5 Provide feedback
This Sec5 family of eukaryotic proteins conserved is not representing the Sec5-Ral binding site.
Sugihara K, Asano S, Tanaka K, Iwamatsu A, Okawa K, Ohta Y;, Nat Cell Biol. 2002;4:73-78.: The exocyst complex binds the small GTPase RalA to mediate filopodia formation. PUBMED:11744922 EPMC:11744922
Internal database links
|Similarity to PfamA using HHSearch:||Dor1|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR029175
This entry represents the yeast Sec5 protein and its homologues from plants and animals.
In S. cerevisiae, Sec5 is an essential component of the exocyst complex, which is composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84 [PUBMED:7615633]. The exocyst complex tethers post-Golgi secretory vesicles to the plasma membrane before soluble NSF attachment protein receptor (SNARE)-mediated membrane fusion [PUBMED:21997494].
In mammals, active form (GTP-bound) of Ral GTPase interacts with Sec5 and Exo84 and regulates the assembly interface of a full octameric exocyst complex [PUBMED:14525976]. Similar to yeast exocyst, the mammalian exocyst has been directly linked to post-Golgi targeting of secretory vesicles to discreet membrane sites [PUBMED:14525976].
|Cellular component||exocyst (GO:0000145)|
|Biological process||Golgi to plasma membrane transport (GO:0006893)|
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 17 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Exo84_C Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Seed source:||Pfam-B_353125 (release 26.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||69|
|Number in full:||615|
|Average length of the domain:||200.60 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||21.84 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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