Summary: Centromere kinetochore component W
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Centromere kinetochore component W Provide feedback
CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.
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Members of this clan all possess a histone fold. Generally proteins in this clan are DNA binding.
The clan contains the following 11 members:Bromo_TP CBFD_NFYB_HMF CENP-S CENP-T CENP-W Histone TAF TAFII28 TFIID-18kDa TFIID-31kDa TFIID_20kDa
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Curation and family details
This family is new in this Pfam release.
|Seed source:||Pfam-B_49340 (release 26.0)|
|Number in seed:||6|
|Number in full:||38|
|Average length of the domain:||87.60 aa|
|Average identity of full alignment:||64 %|
|Average coverage of the sequence by the domain:||99.88 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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