Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 41  species 0  interactions 52  sequences 6  architectures

Family: CENP-C_mid (PF15620)

Summary: Centromere assembly component CENP-C middle DNMT3B-binding region

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Centromere assembly component CENP-C middle DNMT3B-binding region Provide feedback

CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This middle region of CENP-C is the binding-domain for DNMT3B. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions [1,2].

Literature references

  1. Gopalakrishnan S, Sullivan BA, Trazzi S, Della Valle G, Robertson KD;, Hum Mol Genet. 2009;18:3178-3193.: DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. PUBMED:19482874 EPMC:19482874

  2. Cohen RL, Espelin CW, De Wulf P, Sorger PK, Harrison SC, Simons KT; , Mol Biol Cell. 2008; [Epub ahead of print]: Structural and Functional Dissection of Mif2p, a Conserved DNA-binding Kinetochore Protein. PUBMED:18701705 EPMC:18701705


This tab holds annotation information from the InterPro database.

InterPro entry IPR028931

CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This entry represents the middle DNMT3B binding region of CENP-C. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions [PUBMED:1, PUBMED:2].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(20)
Full
(52)
Representative proteomes UniProt
(94)
NCBI
(285)
Meta
(0)
RP15
(3)
RP35
(13)
RP55
(33)
RP75
(51)
Jalview View  View  View  View  View  View  View  View   
HTML View  View               
PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(20)
Full
(52)
Representative proteomes UniProt
(94)
NCBI
(285)
Meta
(0)
RP15
(3)
RP35
(13)
RP55
(33)
RP75
(51)
Alignment: