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3  structures 46  species 0  interactions 66  sequences 8  architectures

Family: CENP_C_N (PF15622)

Summary: Kinetochore assembly subunit CENP-C N-terminal

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Kinetochore assembly subunit CENP-C N-terminal Provide feedback

CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].

Literature references

  1. Gascoigne KE, Cheeseman IM;, Curr Opin Cell Biol. 2011;23:102-108.: Kinetochore assembly: if you build it, they will come. PUBMED:20702077 EPMC:20702077

  2. Przewloka MR, Venkei Z, Bolanos-Garcia VM, Debski J, Dadlez M, Glover DM;, Curr Biol. 2011;21:399-405.: CENP-C is a structural platform for kinetochore assembly. PUBMED:21353555 EPMC:21353555


This tab holds annotation information from the InterPro database.

InterPro entry IPR028052

CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C, proper formation of both centromeres and kinetochores is prevented. In kinetochores, the KMN (KNL1/Mis12/Ndc80) network regulates kinetochore microtubule binding [PUBMED:17129783]. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex to centromeres [PUBMED:20702077, PUBMED:21353555].

Domain organisation

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(14)
Full
(66)
Representative proteomes UniProt
(110)
NCBI
(324)
Meta
(0)
RP15
(6)
RP35
(16)
RP55
(43)
RP75
(62)
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PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(14)
Full
(66)
Representative proteomes UniProt
(110)
NCBI
(324)
Meta
(0)
RP15
(6)
RP35
(16)
RP55
(43)
RP75
(62)
Alignment:
Format:
Order: