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6  structures 94  species 0  interactions 107  sequences 3  architectures

Family: UBZ_FAAP20 (PF15750)

Summary: Ubiquitin-binding zinc-finger

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Ubiquitin-binding zinc-finger Provide feedback

This domain is the ubiquitin-binding zinc-finger of the Fanconi anaemia-associated protein of 20 kDa [1-4].

Literature references

  1. Ali AM, Pradhan A, Singh TR, Du C, Li J, Wahengbam K, Grassman E, Auerbach AD, Pang Q, Meetei AR;, Blood. 2012;119:3285-3294.: FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. PUBMED:22343915 EPMC:22343915

  2. Kim H, Yang K, Dejsuphong D, D'Andrea AD;, Nat Struct Mol Biol. 2012;19:164-170.: Regulation of Rev1 by the Fanconi anemia core complex. PUBMED:22266823 EPMC:22266823

  3. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J;, Proc Natl Acad Sci U S A. 2012;109:4491-4496.: Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. PUBMED:22396592 EPMC:22396592

  4. Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W;, Mol Cell. 2012;47:61-75.: A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. PUBMED:22705371 EPMC:22705371

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR031490

This domain is the type 2 UBZ found in Fanconi anemia-associated protein of 20kDa (FAAP20) [ PUBMED:22343915 , PUBMED:22266823 , PUBMED:22396592 , PUBMED:22705371 ].

The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating beta- beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [ PUBMED:19213613 , PUBMED:27062441 ]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [ PUBMED:24239949 , PUBMED:26506893 , PUBMED:27370208 ], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [ PUBMED:25414354 , PUBMED:25799058 ], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [ PUBMED:17304240 , PUBMED:17550419 , PUBMED:20837403 ], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [ PUBMED:20385554 , PUBMED:25162118 , PUBMED:24794496 ].

The UBZ domain consists of two short antiparallel beta-strands followed by one alpha-helix. The alpha-helix packs against the beta-strands with a zinc ion sandwiched between the alpha-helix and the beta-strands. The zinc ion is coordinated by two cysteines located on the fingertip formed by the beta- strands and two histidines [ PUBMED:19213613 , PUBMED:17304240 ] or one hisidine and one cysteine [ PUBMED:25414354 ] on the alpha-helix [ PUBMED:27062441 ].

Gene Ontology

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Domain organisation

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Curation and family details

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Seed source: Jackhmmer:Q6NZ36
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R
Number in seed: 9
Number in full: 107
Average length of the domain: 34.30 aa
Average identity of full alignment: 63 %
Average coverage of the sequence by the domain: 14.15 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.1 37.6
Noise cut-off 24.8 24.4
Model length: 35
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UBZ_FAAP20 domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
D4AAA5 View 3D Structure Click here
Q3UN58 View 3D Structure Click here
Q6NZ36 View 3D Structure Click here