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63  structures 6431  species 0  interactions 16566  sequences 87  architectures

Family: ACAS_N (PF16177)

Summary: Acetyl-coenzyme A synthetase N-terminus

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acetyl-coenzyme A synthetase N-terminus Provide feedback

This domain is found at the N-terminus of many acetyl-coenzyme A synthetase enzymes.

This tab holds annotation information from the InterPro database.

InterPro entry IPR032387

This domain is found at the N terminus of many acetyl-coenzyme A synthetase enzymes. The function of this domain is not clear.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan ANL (CL0378), which has the following description:

This superfamily consists of enzymes including luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases as well as a plant auxin-responsive promoter family. The name ANL derives from from three of the subfamilies - Acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes [1]. Members of this superfamily catalyse the initial adenylation of a carboxylate to form an acyl-AMP intermediate, followed by a second partial reaction, most commonly the formation of a thioester [1].

The clan contains the following 4 members:

ACAS_N AMP-binding GH3 LuxE

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(702)
Full
(16566)
Representative proteomes UniProt
(64431)
RP15
(2204)
RP35
(7125)
RP55
(15708)
RP75
(26400)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(702)
Full
(16566)
Representative proteomes UniProt
(64431)
RP15
(2204)
RP35
(7125)
RP55
(15708)
RP75
(26400)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(702)
Full
(16566)
Representative proteomes UniProt
(64431)
RP15
(2204)
RP35
(7125)
RP55
(15708)
RP75
(26400)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q9H6R3
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R
Number in seed: 702
Number in full: 16566
Average length of the domain: 56.9 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 8.78 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 55
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ACAS_N domain has been found. There are 63 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044USL6 View 3D Structure Click here
A0A077ZM59 View 3D Structure Click here
A0A0D2DPH1 View 3D Structure Click here
A0A0D2ETX0 View 3D Structure Click here
A0A0D2EYV3 View 3D Structure Click here
A0A0D2G454 View 3D Structure Click here
A0A0D2H6I5 View 3D Structure Click here
A0A0G2K047 View 3D Structure Click here
A0A0H3GL37 View 3D Structure Click here
A0A0K0EKP5 View 3D Structure Click here
A0A0N4U2B1 View 3D Structure Click here
A0A0P0WAB9 View 3D Structure Click here
A0A175VXH8 View 3D Structure Click here
A0A175VYR7 View 3D Structure Click here
A0A175WGR3 View 3D Structure Click here
A0A1C1C6Y9 View 3D Structure Click here
A0A1C1CA54 View 3D Structure Click here
A0A1C1D216 View 3D Structure Click here
A0A1D6DQH1 View 3D Structure Click here
A0A1D6H9J3 View 3D Structure Click here
A0A1D6I3L3 View 3D Structure Click here
A0A1P6BVP6 View 3D Structure Click here
A0A286Y8C0 View 3D Structure Click here
A0B8F1 View 3D Structure Click here
A0KNI2 View 3D Structure Click here
A0L576 View 3D Structure Click here
A0LG91 View 3D Structure Click here
A0R5G1 View 3D Structure Click here
A1S7C8 View 3D Structure Click here
A1SZA2 View 3D Structure Click here
A1UR36 View 3D Structure Click here
A1WY97 View 3D Structure Click here
A3QD52 View 3D Structure Click here
A3QK15 View 3D Structure Click here
A4G3L8 View 3D Structure Click here
A4I093 View 3D Structure Click here
A4I0C2 View 3D Structure Click here
A4VKA0 View 3D Structure Click here
A4YGR1 View 3D Structure Click here
A4YK73 View 3D Structure Click here