# STOCKHOLM 1.0
#=GF ID HIP1_clath_bdg
#=GF AC PF16515.6
#=GF DE Clathrin-binding domain of Huntingtin-interacting protein 1
#=GF AU Coggill P;0000-0001-5731-1588
#=GF GA 28.8 28.8
#=GF NC 28.7 28.7
#=GF TC 28.8 28.9
#=GF SE pdb_2no2
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Coiled-coil
#=GF RN [1]
#=GF RM 17257618
#=GF RT Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil
#=GF RT domain of huntingtin-interacting protein 1 (HIP1) reveals a
#=GF RT surface suitable for clathrin light chain binding.
#=GF RA Ybe JA, Mishra S, Helms S, Nix J;
#=GF RL J Mol Biol. 2007;367:8-15.
#=GF RN [2]
#=GF RM 20179344
#=GF RT Accommodation of structural rearrangements in the
#=GF RT huntingtin-interacting protein 1 coiled-coil domain.
#=GF RA Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ;
#=GF RL Acta Crystallogr D Biol Crystallogr. 2010;66:314-318.
#=GF DR INTERPRO; IPR032422;
#=GF DR SO; 0001080; coiled_coil;
#=GF CC HIP1_clath_bdg is the coiled-coil region of
#=GF CC Huntington-interacting proteins 1. It carries a highly conserved
#=GF CC HADLLRKN sequence motif at its N-terminus which effects the
#=GF CC binding of HIP1R to clathrin light-chain EED regulatory site.
#=GF CC this binding then stimulates clathrin lattice assembly.
#=GF CC Huntingtin-interacting protein 1 (HIP1) is an obligate binding
#=GF CC partner for Huntungtin, and loss of this interaction triggers
#=GF CC the cascade of events that results in the apoptosis of neuronal
#=GF CC cells and the onset of Hungtinton's disease [1]. Clathrin
#=GF CC light-chain binds to a flexible coiled-coil domain in HIP1 and
#=GF CC induces a compact state that is refractory to actin binding [2]. 
#=GF SQ 112
A0A498NYA1.1/455-553   HADLMRK.NAEMVKQVSSTQQAQEELVAYKQQMAV....EMERLKQDNNSTME....AQR.AEIERL..............KQELATERA.EISQVHNALQSKEKAGDQLSS.......VLIGLQAEKEML
A0A498NYA1.1/631-684   -------.---------------------------....-----------TMK....AQR.AEIERL..............KQELATERA.EISQVHNALQSKEKAGDQLSS.......VLIGLQAEKEML
A0A498NYA1.1/751-841   ------Q.EAEIASLRQAAQLHQTTLQQERDRHQR....EMTALQNQLQ--EK....ELQ.LEMDKL..............RRELEEKRV.ELLRAQSTLNSKETTGDQLSS.......VLVGLQAEKEVL
M7BMZ0.1/272-317       HAELLRK.NADTAKQLTVTQQSQEEVALVKEQLAF....QMEQVKRESEMK--....---.------..............---------.---------------------.......------------
M7BMZ0.1/317-409       ------K.NADTAKQLTVTQQSQEEVALVKEQLAF....QMEQVKRESEMKLE....DQT.LQMEQL..............KRELEAKKE.ELTQIQSSLSNSKQAGSELHS.......QVEALHAEKDSL
A0A1S3KW91.1/457-555   HADLLKK.NAETVRFLSSTQQNQEELATAKQQLAS....EVDHLRQENRLKLE....QQK.QEIDRL..............NRELLEQRA.ALGEVHSALDNKEMAGSQMTG.......ALQGLQREREEL
A0A1S3KW91.1/561-657   -----EK.EGEVSSLQQQAQLHHSSMEQDRDRSAR....EIASLRQQLQQQLAi.naEQR.LEIDRL..............KRELEQSRA.EVSRANNALQSKEMTGSQMNS.......ALMGLQTEREGL
A0A0R4ITB0.1/294-392   HAELLRK.SADTVKMLSATQQTQEEIERTKQQLAF....EVDRVKQESDMKFD....EQK.FEMDKL..............KRELEAKAA.EIQKVRSSLQTSEMTGVHMNS.......SMAALQAEKDRL
A0A0R4IKR8.1/467-565   HAELLRK.SADTVKMLSATQQTQEEIERTKQQLAF....EVDRVKQESDMKFD....EQK.FEMDKL..............KRELEAKAA.EIQKVRSSLQTSEMTGVHMNS.......SMAALQAEKDRL
K7EA25.1/283-381       HAELLRK.NADTAKQLSVTQQSQEEVARVKEQLAF....QMEQVKRESDMKLE....DQS.YQLDQL..............KRELEAKAG.ELARVQETLSHSEQSGSELNT.......RLDALRTEKDFL
F7AYT2.1/463-561       HAELLRK.NADTAKQLSVTQQSQEEVARVKEQLAF....QMEQVKRESDMKLE....DQS.YQLDQL..............KRELEAKAG.ELARVQETLSHSEQSGSELNT.......RLDALRTEKDFL
F6V0I5.2/420-518       HADLLRK.NAEVTKQVTVARQAQGDVEREKKELEH....SFQRVSEQAQRKTQ....EQT.EVLETL..............KRELAASKQ.ELQTVKGTLETSAQSEAERGA.......QLAGLEAERASL
F6V0K8.1/420-518       HADLLRK.NAEVTKQVTVARQAQGDVEREKKELEH....SFQRVSEQAQRKTQ....EQT.EVLETL..............KRELAASKQ.ELQTVKGTLETSAQSEAERGA.......QLAGLEAERASL
A0A4U5S202.1/432-530   HADLLRK.NAEVTKQVSVARQAQADLEREKKELED....SFQRISDQAQRKTQ....EQT.EVLESL..............KQELATSKQ.ELQIVQGSLESSAQSEAKWTA.......QIAELEKERGSL
L9KF35.1/473-571       HADLLRK.NAEVTKQVSVARQAQADLEREKKELED....SFDRVSDQAQRKTQ....EQL.EVLENL..............KQELTASKQ.ELQVLQGSLETSAQSEAKWAT.......EITRLEKERDSL
A0A498LXC6.1/267-365   HAELLRK.SADTVKMLSATQQTQEEIERTKQQLAF....EVERVRQESDMKFE....EQR.FDMDRL..............RRELEEKNA.EIQKVKTLLQTSEKAGEQVNS.......SLAALRAEKERL
A0A498NW81.1/384-482   HAELLRK.SADTVKMLSATQQTQEEIERTKQQLAF....EVERVRQESDMKFE....EQR.FDMDRL..............RRELEEKNA.EIQKVKTLLQTSEKAGEQVNS.......SLAALRAEKERL
A0A226MLH7.1/349-447   HADLLRK.NAEVTKQVTVARQAQGDVEREKKELED....SFQRVSEQSQRKSQ....EQA.EVLETL..............KRELAASKQ.ELQVLQGTLETSMQVGAEQNT.......RIAGLEQERDSL
L9KRW2.1/1276-1374     HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKRESEMKLE....EQS.DQLEKL..............RRELETKDG.ELARVQATLSHTEQSGSELSS.......RLDALNAEKEAL
A0A0Q3UPU3.1/462-560   HADLLRK.NAEVTKQVTAARQAQGDVEREKKELED....SFQRVXEQAQRKSQ....EQA.EVLDTL..............KRELAASRQ.ELQVLQGTLESSTQVGAEQST.......RIAGLEQERDSL
W5ME89.1/467-565       HAELLRK.SADTVKMLSATQQTQEEVARTKQQLTF....EMERIKQEAEMKLE....EQK.FDMEKL..............KRELGERKT.ELLRVQNTLLSNEKAGEKLSG.......TLEGLQAEKEVL
R0K221.1/417-515       HADLLRK.NADVTKQVTVARQAQGDVEREKKELED....SFQRVSEQAQRKSQ....EQA.EVLEML..............KQELAASKQ.ELQVLQGTLESSTQVGAEQST.......RIADLEQERDSL
F1LML7.1/462-560       HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QMEQVKRESEMKME....EQS.DQLEKL..............KRELVAKAG.ELAHAQEALSRTEQSGSELSS.......RLDTLNAEKEAL
F7E260.1/427-525       HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QMEQVKRESEMKLE....DQS.YQLEKL..............KRELEAKAG.ELVRVQETLSHKEQSGSELSS.......KLDAMHLEKESL
H3C5L8.1/468-566       HAELLRK.SADTVRMLSATQQTQDEVERTKQQLSF....EIDRVKQESDMKLE....EQK.FEIEKL..............RRDLQEKMA.EVTRIKANLQSSEKVSEQVSS.......SMTALQAEKERL
A0A1S3NMY1.1/466-564   HAELLRK.SADTVKMLSATQQTQEEVERTKQQLAF....EVDRIKQDADMKLE....EQK.FEMEKL..............KREFEEKKA.EVERVKGTLQSNEKVGEQQTR.......SMSALQAEKERL
A0A1S3NMX8.1/467-565   HAELLRK.SADTVKMLSATQQTQEEVERTKQQLAF....EVDRIKQDADMKLE....EQK.FEMEKL..............KREFEEKKA.EVERVKGTLQSNEKVGEQQTR.......SMSALQAEKERL
H3DEG9.1/468-566       HAELLRK.SADTVRMLSATQQTQDEVERTKQQLSF....EIDRVKQESDMKLE....EQK.FEIEKL..............RRDLQEKMA.EVTRIKANLQSSEKVSEQVSS.......SMTALQAEKERL
A0A1D5PJJ8.2/445-543   HADLLRK.NAEVTKQVTVARQAQGDVEREKKELED....SFQRVSEQSQRKSQ....EQA.EVLETL..............KQELAASKQ.ELQVLQGTLETTIQVGAEQNT.......RIAGLEQERDSL
Q9JKY5.2/461-559       HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QMEQAKRESEMKME....EQS.DQLEKL..............KRELAARAG.ELARAQEALSRTEQSGSELSS.......RLDTLNAEKEAL
R0K194.1/427-525       HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLEF....QVEQVKREAEMKLE....DQS.VQMEQL..............RRELDARRD.ELDQAQSSLSHAKQAGSELSA.......QLETLQAEKEQL
H9GMU9.2/459-557       HAELLRK.NADTAKQLTVTQQSQEQVARVKEQLAF....QMEQAKRESEMKLE....DQI.LQMEQL..............KREMESKKD.ELAQLQESLGRSKQLGSDLNS.......QLDALQSEKDTL
A0A1A6GUB1.1/485-583   HAELLRK.NADTAKQLTVTQQSQEEVARIKEQLAF....QMEQVKRESEMKME....EQS.DQLERL..............KRELAAKAG.ELAHAQEALSRTEQNGSELSS.......RLDTLNAEKDAL
A0A401S0S8.1/456-554   HAELLRK.SAETTKQLTVTQQTREEVARTKQELEF....AMEEAKREAEMKLE....DQN.FVMEQL..............KRELAASKE.ELSTIQVSLRNSEQASSEMNS.......RLQGLEAEKDNL
A0A0P7UYQ1.1/89-187    HAELLRK.SADTVKMLSATQQTQEEVARTKQQLAF....EVERIKQEADMKLE....EQK.FEMDKL..............RRELEERQT.ELSRFQSSLQSNVAAGEKMNM.......ALQSLQAEKEAL
A0A402EN04.1/439-537   HADLLRK.NAEVTKQVTVARQVQGDVEREKKELED....SFQQLSKQAQRKTQ....EQA.EVLETL..............KRELLASKQ.EIQSLRGTVESSTQSEAEQST.......QLAGLRQERDTL
A0A1S3PGS2.1/446-544   HAELLRK.SADTVRILSATQQTQEEVERTKQQLAF....EVDRIKLDADMKLE....EQK.FEMKKL..............KRDFEEKRA.EVEHVKGTLQRTEKVGEQLTS.......SMLALQAEKERL
A0A1S3PGS1.1/463-561   HAELLRK.SADTVRILSATQQTQEEVERTKQQLAF....EVDRIKLDADMKLE....EQK.FEMKKL..............KRDFEEKRA.EVEHVKGTLQRTEKVGEQLTS.......SMLALQAEKERL
A0A1U8D7R9.1/427-525   HAELLRK.NADTAKQLTVTQQSQEEVARIKEQLAF....QIEQVKREAEMKLE....DQT.LQMEQL..............KRELETKKE.ELMQSQQSLSHSKDTGSELSS.......RLEALHAEKDSL
A0A1S3PHC9.1/464-562   HAELLRK.SADTVRILSATQQTQEEVERTKQQLAF....EVDRIKLDADMKLE....EQK.FEMKKL..............KRDFEEKRA.EVEHVKGTLQRTEKVGEQLTS.......SMLALQAEKERL
A0A4U5RIK0.1/283-381   HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKRESEMKLE....EQS.DQLEKL..............KRELEAKAG.ELVRAQEALSRTEQSGSELSL.......RLDALSAEKDEL
O00291.5/482-580       HADLLRK.NAEVTKQVSMARQAQVDLEREKKELED....SLERISDQGQRKTQ....EQL.EVLESL..............KQELATSQR.ELQVLQGSLETSAQSEANWAA.......EFAELEKERDSL
A0A402F8B0.1/568-666   HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QMEQVKRESEMKLE....DQL.LQMEQA..............KRDLEAKKE.ELAHLQQSLSQSKQVGSDLNS.......ELEALQAEKDAL
A0A3M0K3F8.1/1167-1265 HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKREAEMKLE....DQS.VQMEQL..............RRELDARRD.ELEQAQRSLSHAKQAGAELSA.......QVDALHAEKEVL
A0A3L8SBW9.1/475-573   HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKREAEMKLE....DQS.VQLEQL..............RQELDARRD.ELEQAQRSLSHAKQAGVELSA.......QVDALHAEKEVL
A0A401P2S9.1/343-441   HAELLRK.SAETTKQLTVTQQTREEVARTKQELEF....AMEEAKREAETKLD....DQS.FIMEQL..............KRELTANKE.ELSIIQSSLQSSEQVGFETNS.......RLQGLEAEKDNL
L5K698.1/578-676       HADLLRK.NAEITKQVSVARQAQVDLEQEKRELED....SFQRISEQAQRKTQ....EQT.EVLENL..............KQELATSKQ.ELQIVQGSLETSALAEVKWAT.......QIANLEKERGSL
G3HA18.1/526-624       HADLLRK.NAEVTKQVSVARQAQVDLEREKKELED....SFARVSDQAQRKTQ....EQQ.DVLENL..............KHELASSRQ.ELQVLHSSLETSAQSEAKWLT.......QIAELEKEQGSL
A0A1D5PCR1.1/459-557   HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKREAELKLE....DQS.MQMEQL..............RQELEARRD.ELDQAQRSLGHAKQAGTELSA.......QLETLQAEKEQL
G5BG68.1/420-518       HADLLRK.NAEVTKQVSMARQAQADLEREKKELED....SFEHVSDQAQRKTQ....EQQ.EVLESL..............KQELATSRQ.ELQLLHSNLETSAKSEAKCTV.......QITELEKERDSL
W5LYY1.1/488-586       HADLLRK.NAEVTKQMTVARAAQDEVESVRREMQE....KVRAAREEAEHQEK....EQA.EQLQAF..............QTELCTSRA.ELERLRGTMASSQQSSAELSS.......RLAALEAEKAAL
L5KTZ1.1/1084-1182     HAELLRK.NADTARQLTAKQQSQEEVSRVKEQLAF....QMEQAKRESEMKLE....EQS.DQLDKL..............RRELEAKAG.ELVRVREALSHTEQSGSELSS.......RLDSLRAEKDAL
B1H2Q0.1/462-560       HAGLLRK.NADTAKQLTVSQQNQEEVARIKEELEF....QMDQVKRESDLKLE....DQS.FQTEQL..............KSEIEAKKK.ELLLIQQSLSSTEESKSQLNS.......TLMSLEVEKDTL
F6UZ89.1/462-560       HAGLLRK.NADTAKQLTVSQQNQEEVARIKEELEF....QMDQVKRESDLKLE....DQS.FQTEQL..............KSEIEAKKK.ELLLIQQSLSSTEESKSQLNS.......TLMSLEVEKDTL
O75146.2/461-559       HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKRESELKLE....EKS.DQLEKL..............KRELEAKAG.ELARAQEALSHTEQSKSELSS.......RLDTLSAEKDAL
H3BEK4.1/432-528       HAELLRK.NADTAKQLTATQQVQEDVARTIETLQF....EVDQGKRESEMKLE....EQT.FLTEQL..............KQELEARKE.ELANVQLSLNSSEQAGSQLKS.......RLQELQDENS--
H3BI26.1/444-542       HADLLRK.NAEVTKQVTVARQAQGDAERLRKELED....NVQRFQEQTQQKTQ....EQT.ETLKSF..............QMELTASRQ.ELETLKASLQTSTQSSTELAS.......KVSSLELEKSSL
F6YXY3.2/425-523       HADLLRK.NAEVTKQVTVMRQAQADLQREKKELEE....SFHRASEQAQQKTQ....EQM.EVVENL..............KQELSISKH.EFQVLQGTLETSAQSEAKRNI.......QLEELEKERSSL
A0A3B4A6A6.1/475-573   HADLLRK.NAEVTRQMTVARAAQDEVEAVRREMQE....KVKVAQEAADRQEK....AQQ.EQLQEL..............QRELLSSRT.ELESLKSTVTSSQQSSEALNT.......QLAALESEKADL
A0A3Q0HIH1.1/363-460   HADLLRK.NAEVTRQVTVARQAQGDMEQEKKELED....SFQRMSEQTQRKSQ....EQT.EVLETL..............KRELAASKQ.ELQSLQSTLESSTRLRGEQST.......RIASLEQEKDS-
M7B4M2.1/405-503       HADLLRK.NAEVTKQVTVARQAQGDVEQEKKELED....SFQRMSEQAQRKTQ....EQA.EVLETL..............KRELTASKQ.EQQALQSTLKSSLQSEAERST.......RTAGLEQERDTL
A0A1U8DSM8.2/363-460   HADLLRK.NAEVTRQVTVARQAQGDMEQEKKELED....SFQRMSEQTQRKSQ....EQT.EVLETL..............KRELAASKQ.ELQSLQSTLESSTRLRGEQST.......RIASLEQEKDS-
A0A2R8QJ16.1/461-559   HADLLRK.NAEVTRQMTVARAAQDEVENVKKEMQD....RLKVAQDSASQQEK....AQL.EQLQAL..............QAELMSSRT.ELETLKSTVTSSQQSNEQLGT.......QLSALVAEKAGL
X1WBM9.1/483-581       HADLLRK.NAEVTRQMTVARAAQDEVENVKKEMQD....RLKVAQDSASQQEK....AQL.EQLQAL..............QAELMSSRT.ELETLKSTVTSSQQSNEQLGT.......QLSALVAEKAGL
F1R6L2.3/483-581       HADLLRK.NAEVTRQMTVARAAQDEVENVKKEMQD....RLKVAQDSASQQEK....AQL.EQLQAL..............QAELMSSRT.ELETLKSTVTSSQQSNEQLGT.......QLSALVAEKAGL
A0A2R8QB02.1/478-576   HADLLRK.NAEVTRQMTVARAAQDEVENVKKEMQD....RLKVAQDSASQQEK....AQL.EQLQAL..............QAELMSSRT.ELETLKSTVTSSQQSNEQLGT.......QLSALVAEKAGL
A0A1S3SYB6.1/452-550   HADLLRK.NAEVTRQMTVARAAQDEVDSVRREMQE....KVKAAQEAAERREQ....EQV.EQLQEL..............QRELISSRA.ELDTLKSTMASSQQSSEELSS.......QLSTVESEKVEL
A0A1S3SYB2.1/486-584   HADLLRK.NAEVTRQMTVARAAQDEVDSVRREMQE....KVKAAQEAAERREQ....EQV.EQLQEL..............QRELISSRA.ELDTLKSTMASSQQSSEELSS.......QLSTVESEKVEL
H3BX68.1/438-536       HADLMKK.NADTVKLLSTSKQDQEDLLRAKHQLET....QLENLRQEQKNMAN....QQQ.QEVQQL..............NQDLAQQKA.EVMALRSSLGNKEKSGTQLSS.......TLAGLQAEREVL
A0A3L8S6H6.1/462-563   HADLLRK.NAEVTKQITVARQAQGDVEREKKELED....SFQRVSEQAQRKSQ....EQA.EVLETL..............KRELAASRQ.ELQVLQGTLDSSTQERDRLNQaaeqhwdKMAALQAE----
A0A3L8S6W2.1/517-618   HADLLRK.NAEVTKQITVARQAQGDVEREKKELED....SFQRVSEQAQRKSQ....EQA.EVLETL..............KRELAASRQ.ELQVLQGTLDSSTQERDRLNQaaeqhwdKMAALQAE----
A0A3B3HVX5.1/482-580   HADLLRK.NAEVTRQMTVARAAQDEVEVLKKEMQE....KVKAVQDVADRQER....EQQ.RQLEDI..............QKELVCTRE.ELDTLKSSVTSSQQSREALSS.......QMAALESEKAEL
A0A3B3HDU1.1/449-547   HADLLRK.NAEVTRQMTVARAAQDEVEVLKKEMQE....KVKAVQDVADRQER....EQQ.RQLEDI..............QKELVCTRE.ELDTLKSSVTSSQQSREALSS.......QMAALESEKAEL
A0A3B3I1A4.1/482-580   HADLLRK.NAEVTRQMTVARAAQDEVEVLKKEMQE....KVKAVQDVADRQER....EQQ.RQLEDI..............QKELVCTRE.ELDTLKSSVTSSQQSREALSS.......QMAALESEKAEL
A0A4W3GWT4.1/36-134    HAELLRK.NAEVTRQMTGARQAQEDVEQVKKELEE....SVRRVREESQHKAQ....EQT.QILESL..............GKELKCRNE.ELQSLRASQELSQQTSTELAE.......KLAALGQERATL
H3D9K5.1/444-542       HADLLRK.NAEVTRQMTVARAVQDEVDAVRREMQG....KLRAAQERAEKQAM....EQL.DQLQEL..............QRELTTRTM.ELESFKGTMDSSEQSNKVLST.......QLGAVETEKAEL
H3D7L3.1/455-556       HADLMKK.NADTVKLLSTSKQDQEDLLRAKHQLET....QLENLRQEQKNMLNi.naEQK.LEIDRL..............KRELEMARA.DLTRANSNLQSREMSGTQLSS.......TLAGLQAEREVL
H3C8Z1.1/433-531       HADLLRK.NAEVTRQMTVARAVQDEVDAVRREMQG....KLRAAQERAEKQAM....EQL.DQLQEL..............QRELTTRTM.ELESFKGTMDSSEQSNKVLST.......QLGAVETEKAEL
A0A226N977.1/447-529   HAELLRK.NADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKREAELKLE....DQS.VQMEQL..............RQELEERRD.ELDQAQRSLGHAKQAGS----.......------------
A0A4W3GTF6.1/36-134    HAELLRK.NAEVTRQMTGARQAQEDVEQVKKELEE....SVRRVREESQHKAQ....EQT.QILESL..............GKELKCRNE.ELQSLRASQELSQQTSTELAE.......KLAALGQERATL
K7GCX2.1/432-534       HAELLRK.NADTAKQLTVTQQSQEEVIHCASALKFpegsKFSGVTNDSGTTLE....DQT.LQMEQL..............KRELEAKKD.ELTQIQSSLSHSKQAGSELHS.......QVEALHAEKDSL
A0A1S3NR35.1/486-584   HAYLLRK.NAEVTRQMTVARAAEDEVDSVRREMQE....KVKAAKEAAERREQ....EQV.DQLQEL..............QRELISSRA.ELDTLKSTMASSQQSSEELSS.......QFSTMESEKVEL
A0A1S3NR16.1/487-585   HAYLLRK.NAEVTRQMTVARAAEDEVDSVRREMQE....KVKAAKEAAERREQ....EQV.DQLQEL..............QRELISSRA.ELDTLKSTMASSQQSSEELSS.......QFSTMESEKVEL
A0A0Q3MMC9.1/3-94      -------.XADTAKQLTVTQQSQEEVARVKEQLAF....QVEQVKREAEMKLE....DQS.LQMEQL..............RQELDARRE.ELEQAQRSLSHAKQAGTELSA.......QVEALHAEKEVL
A0A1A6HWJ7.1/315-410   ---LLFQ.NAEVTKQVSVARQAQVDLEREKKELED....SFARVSDQAQRKTQ....EQQ.DVLENL..............XHELATSRQ.ELQVLHSNLETSAQSEAKWLT.......QIAELEKEQGSL
E7FD55.3/270-358       HADLMRK.NAEMLKQKSSGQQAQEELLAYRQQVAQ....EMQQLTLDNNSKLE....AQR.AEIERL..............KQELVSGRA.EVSQVHNALQSKEKVSVRMSL.......CV----------
A0A401SM84.1/431-529   HADLLRK.NADVAKQMTSFRQTQEDMEQVKKELEE....TVHQLKEDIQQKAQ....EQS.CVLEAL..............QKELKSRNE.EVESLKNSHADSQQASTVMAS.......TIESLTSEKKML
A0A3M0KUZ3.1/508-598   HADLLRK.NAEVTKQITVARQAQGDAEQEKKELED....SFQR--------SQ....EQA.EVLETL..............KRELAASRQ.ELQVLQGTLESSTQAGAEQNN.......RIASLEQERDRL
A0A401NHM7.1/493-591   HADLLRK.NAEVTKQITSFRQTQEDMEQVKKELEE....TVHQLKQDFQQKAQ....EQT.RVLESL..............QKELRSRNQ.ELGTLKNLHEDSQQASTVMAS.......TIESLTSEKKVL
A0A498MUB3.1/431-514   -------.-------GSRAQTAQIHFTRLKEKHAE....LVSR-HADLMRKMK....AQR.AEIERL..............KQELATERA.EISQVHNALQSKEKAGDQLSS.......VLIGLQAEKEML
A0A498MUB3.1/522-616   -------.EAEIASLRQAAQLHQTTLQQERDRHQR....EMTALQNQLQEKLCr.eqELQ.LEMDKL..............RRELEEKRV.ELLRAQSTLNSKETTGDQLSS.......VLVGLQAEKEVL
G3V8Y8.1/482-572       HADLLRK.NAEVTKQVSVARQAQVDLEREKKELAD....SFAR--------TQ....EQQ.DVLETL..............KHELATSRQ.ELQVLHGNLETSAQSEAKWLT.......QIAELEKEQGSL
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