# STOCKHOLM 1.0 #=GF ID HIP1_clath_bdg #=GF AC PF16515.6 #=GF DE Clathrin-binding domain of Huntingtin-interacting protein 1 #=GF AU Coggill P;0000-0001-5731-1588 #=GF SE pdb_2no2 #=GF GA 28.80 28.80; #=GF TC 28.80 28.90; #=GF NC 28.70 28.70; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Coiled-coil #=GF RN [1] #=GF RM 17257618 #=GF RT Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil #=GF RT domain of huntingtin-interacting protein 1 (HIP1) reveals a #=GF RT surface suitable for clathrin light chain binding. #=GF RA Ybe JA, Mishra S, Helms S, Nix J; #=GF RL J Mol Biol. 2007;367:8-15. #=GF RN [2] #=GF RM 20179344 #=GF RT Accommodation of structural rearrangements in the #=GF RT huntingtin-interacting protein 1 coiled-coil domain. #=GF RA Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ; #=GF RL Acta Crystallogr D Biol Crystallogr. 2010;66:314-318. #=GF DR INTERPRO; IPR032422; #=GF DR SO; 0001080; coiled_coil; #=GF CC HIP1_clath_bdg is the coiled-coil region of #=GF CC Huntington-interacting proteins 1. It carries a highly conserved #=GF CC HADLLRKN sequence motif at its N-terminus which effects the #=GF CC binding of HIP1R to clathrin light-chain EED regulatory site. #=GF CC this binding then stimulates clathrin lattice assembly. #=GF CC Huntingtin-interacting protein 1 (HIP1) is an obligate binding #=GF CC partner for Huntungtin, and loss of this interaction triggers #=GF CC the cascade of events that results in the apoptosis of neuronal #=GF CC cells and the onset of Hungtinton's disease [1]. Clathrin #=GF CC light-chain binds to a flexible coiled-coil domain in HIP1 and #=GF CC induces a compact state that is refractory to actin binding [2]. #=GF SQ 30 #=GS W5ME89_LEPOC/467-565 AC W5ME89.1 #=GS G3NZW0_GASAC/469-567 AC G3NZW0.1 #=GS W5KP00_ASTMX/467-565 AC W5KP00.2 #=GS A0A0R4ITB0_DANRE/294-392 AC A0A0R4ITB0.1 #=GS I3K6G4_ORENI/469-567 AC I3K6G4.1 #=GS I3KDT8_ORENI/558-653 AC I3KDT8.1 #=GS E7FD55_DANRE/270-359 AC E7FD55.3 #=GS H2VDR8_TAKRU/451-549 AC H2VDR8.2 #=GS I3KDT8_ORENI/453-551 AC I3KDT8.1 #=GS W5LJJ0_ASTMX/391-489 AC W5LJJ0.2 #=GS H3BEK4_LATCH/432-528 AC H3BEK4.1 #=GS B1H2Q0_XENTR/462-560 AC B1H2Q0.1 #=GS W5LYY1_LEPOC/488-586 AC W5LYY1.1 #=GS X1WBM9_DANRE/483-581 AC X1WBM9.1 #=GS W5LEV3_ASTMX/449-547 AC W5LEV3.1 #=GS H2SLQ3_TAKRU/442-540 AC H2SLQ3.2 #=GS I3JE79_ORENI/484-582 AC I3JE79.1 #=GS H3BI26_LATCH/444-542 AC H3BI26.1 #=GS F6V0I5_ORNAN/420-518 AC F6V0I5.2 #=GS U3KH00_FICAL/356-454 AC U3KH00.1 #=GS F6UB46_HORSE/394-492 AC F6UB46.2 #=GS G1SI95_RABIT/426-524 AC G1SI95.2 #=GS F7IAE5_CALJA/477-575 AC F7IAE5.2 #=GS H0WIH4_OTOGA/447-545 AC H0WIH4.1 #=GS I3NBU9_ICTTR/442-532 AC I3NBU9.2 #=GS G3WQE1_SARHA/439-537 AC G3WQE1.1 #=GS F1LML7_RAT/462-560 AC F1LML7.1 #=GS K7EA25_ORNAN/283-381 AC K7EA25.1 #=GS U3I4P3_ANAPP/459-557 AC U3I4P3.2 #=GS H9GMU9_ANOCA/459-557 AC H9GMU9.2 W5ME89_LEPOC/467-565 HAELLRKSADTVKMLSATQQTQEEVARTKQQLTFEMERIKQEAEMKLE...EQKFDMEKLKRELGERKTELLRVQNTLLSNEKAGEKLSGTLEGLQAEKEVL G3NZW0_GASAC/469-567 HAELLRRSADTVRMLSATQQTQEEVERTKLQLAFEVDRIKQEADMKLD...EKKFEMEKLKRELEEKMAEVMRIRGTLKDSEQTSEQMNSSVTALQAEKERL W5KP00_ASTMX/467-565 HAELLRKSADTVKMLSATQQTQEEVERTKQQLAFEVERAKQESDMKLE...EQKFEMDKLRRDLEEKILEIQRMKGTLQTCEKASDQINSSMTSLQVEKERL A0A0R4ITB0_DANRE/294-392 HAELLRKSADTVKMLSATQQTQEEIERTKQQLAFEVDRVKQESDMKFD...EQKFEMDKLKRELEAKAAEIQKVRSSLQTSEMTGVHMNSSMAALQAEKDRL I3K6G4_ORENI/469-567 HAELLRKSADTVKMLSVTQQTQEEVERTKQQLTFEMDRVKQEADMKME...EQRFEVERVKRELEEKMAEVTRIKATLQSSEKTSEHMNSSMTALQAEKERL I3KDT8_ORENI/558-653 ......KDAELTTLRQQAQLQQSSLDLERDRTNRELEDLRAQLQRQLAINAEQKLEIDRLKRDLESTRAELAKANNILQNKEMSGTQLNNTLAGLQVEKEGL E7FD55_DANRE/270-359 HADLMRKNAEMLKQKSSGQQAQEELLAYRQQVAQEMQQLTLDNNSKLE...AQRAEIERLKQELVSGRAEVSQVHNALQSKEKVSVRMSLCV.........I H2VDR8_TAKRU/451-549 HADLMKKNADTARLLSATKQEQDDLLRAKRQVENELENLRQEKRNMVN...QQQQEAQQLNQDLLQQKAEVTALRSSLENKEKEGSQVSSSLAALQAEREVL I3KDT8_ORENI/453-551 HADLMKKNTETVKILSSTKQEHDDLQRAKYQLETELESLRREKTNVMN...QQQMEVDRLNQELLEQRAELATLRSTLESKEKEGSQVSSSLTALQAEREVL W5LJJ0_ASTMX/391-489 HADLMRKNTDTVKQLTSTQHVQEELVRAKQQMAEELEKLKQENSMMLE...AQKAEIVRLKQELLSGKAEITQVQSALQTKEKSGDQLSSLLVGLQTEKEML H3BEK4_LATCH/432-528 HAELLRKNADTAKQLTATQQVQEDVARTIETLQFEVDQGKRESEMKLE...EQTFLTEQLKQELEARKEELANVQLSLNSSEQAGSQLKSRLQELQDENS.. B1H2Q0_XENTR/462-560 HAGLLRKNADTAKQLTVSQQNQEEVARIKEELEFQMDQVKRESDLKLE...DQSFQTEQLKSEIEAKKKELLLIQQSLSSTEESKSQLNSTLMSLEVEKDTL W5LYY1_LEPOC/488-586 HADLLRKNAEVTKQMTVARAAQDEVESVRREMQEKVRAAREEAEHQEK...EQAEQLQAFQTELCTSRAELERLRGTMASSQQSSAELSSRLAALEAEKAAL X1WBM9_DANRE/483-581 HADLLRKNAEVTRQMTVARAAQDEVENVKKEMQDRLKVAQDSASQQEK...AQLEQLQALQAELMSSRTELETLKSTVTSSQQSNEQLGTQLSALVAEKAGL W5LEV3_ASTMX/449-547 HADLLRKNAEVTRQMTVVRAAQDEVETVKREMLEKVKAAQENASQQEK...IQTEQLQALQADLTASRTELETLKASMASSQKSGEELSTQVAALEMEKAGL H2SLQ3_TAKRU/442-540 HADLLRKNAEVTRQMSVARVAQDEVDAVRREMQEKLKAAQEYAERQEK...EQLMQLQELQAELASRSLELESFKGTVDSSEQSNKVLSTQLVALETEKAEL I3JE79_ORENI/484-582 HADLLRKNAEVTRQMTVARAAQDEVEAVRKEMQEKVKAAQEAADRQER...EQLEQLQQLQRELVSSRAELDSLKTSMASSQQSSEVLGTQLAALESEKAEL H3BI26_LATCH/444-542 HADLLRKNAEVTKQVTVARQAQGDAERLRKELEDNVQRFQEQTQQKTQ...EQTETLKSFQMELTASRQELETLKASLQTSTQSSTELASKVSSLELEKSSL F6V0I5_ORNAN/420-518 HADLLRKNAEVTKQVTVARQAQGDVEREKKELEHSFQRVSEQAQRKTQ...EQTEVLETLKRELAASKQELQTVKGTLETSAQSEAERGAQLAGLEAERASL U3KH00_FICAL/356-454 HADLLRKNAEVTKQITVARQAQGDVEREKKELEDSFQRVSEQAQRKSQ...EQAEVLETLKRELATSRQELQVLQGTLESSTQAGAEQSTRIASLEQERDRL F6UB46_HORSE/394-492 HADLLRKNAEVTKQVSVARQAQVDLEREKKELEDSFQRLSEQAQRKTQ...EQTEVLENLKQELATSKQELHIVQGSLETSAQSEEKWATQIAELEKERDSL G1SI95_RABIT/426-524 HADLLRKNAEVTKQVSVARQAQVDLEREKKELEDSFERVSDQTQRKTE...EQQELLESLKQELATSKQELQVLQSSLEASAQSEATRAAQITELETERDSL F7IAE5_CALJA/477-575 HADLLRKNAEVTKQVSVARQAQVDLEREKKELEDSLERIGDQGQRKTQ...EQLEVLESLKQELATSQQELQVLQGSLETSAQSEANWAAQITELEKERDSL H0WIH4_OTOGA/447-545 HADLLRKNAEVTKQVSMARQTHIDLEREKKELEDTLERISEQGQRKTQ...EQLEVLESLKQELNTSKVELQVLQSSLETSAQSEVKWANQITDLEKERANL I3NBU9_ICTTR/442-532 HADLLRKNAEVTKQVSVARQAQVDLEREKKELEDSMER........TQ...EQQGILESLKQELTTSRQELQLLHSSLDTSAESEAKWTMKVAELEEERGSL G3WQE1_SARHA/439-537 HADLLRKNAEVAKQVTVMRQAQADLQREKKELEDTFHRANEQAQRKTQ...EQTEVLETLKQELAISKHEFQVLQGTLETSAQSEAKWTLQVEGLERERASL F1LML7_RAT/462-560 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKME...EQSDQLEKLKRELVAKAGELAHAQEALSRTEQSGSELSSRLDTLNAEKEAL K7EA25_ORNAN/283-381 HAELLRKNADTAKQLSVTQQSQEEVARVKEQLAFQMEQVKRESDMKLE...DQSYQLDQLKRELEAKAGELARVQETLSHSEQSGSELNTRLDALRTEKDFL U3I4P3_ANAPP/459-557 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLEFQVEQVKREAEMKLE...DQSVQMEQLRRELDARRDELDQAQSSLSHAKQAGTELSAQLETLQAEKEQL H9GMU9_ANOCA/459-557 HAELLRKNADTAKQLTVTQQSQEQVARVKEQLAFQMEQAKRESEMKLE...DQILQMEQLKREMESKKDELAQLQESLGRSKQLGSDLNSQLDALQSEKDTL #=GC seq_cons HADLLRKNA-ssKQloVspQuQ--l-RsKcpLppph-plpcpuphKhc...EQp.pl-pLKpELtsp+sELpplpuoLpoSpQSuspluoplsuLpsEK-sL //