# STOCKHOLM 1.0 #=GF ID FOXO-TAD #=GF AC PF16676.6 #=GF DE Transactivation domain of FOXO protein family #=GF AU Coggill P;0000-0001-5731-1588 #=GF GA 27.4 27.4 #=GF NC 25.0 23.8 #=GF TC 28.6 27.9 #=GF SE Pfam-B_10880 (release 27.0) #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 22474372 #=GF RT Structures of KIX domain of CBP in complex with two FOXO3a #=GF RT transactivation domains reveal promiscuity and plasticity in #=GF RT coactivator recruitment. #=GF RA Wang F, Marshall CB, Yamamoto K, Li GY, Gasmi-Seabrook GM, Okada #=GF RA H, Mak TW, Ikura M; #=GF RL Proc Natl Acad Sci U S A. 2012;109:6078-6083. #=GF DR INTERPRO; IPR032067; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC TAD is a promiscuous binding domain that mediates the #=GF CC association of the transcription factor FOXO with the #=GF CC coactivator CBP/p300. Both this domain and the FOXO-KIX_bd #=GF CC family Pfam:PF16675 bind simultaneously the KIX domain of #=GF CC CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though #=GF CC binding to these two regions. The promiscuity of the TAD is #=GF CC further evidenced by that the finding that they also bind the #=GF CC TAZ1 and TAZ2 domains of CBP/p300. #=GF SQ 58 A0A401P1M7.1/578-618 QDKFPSDLD..LDM...FNGSL..DCDVESIIRNELMDA.DGLDFNFDS- A0A3M0IQP3.1/391-431 QDRFPADLD..LDM...FNGSL..ECDVESIILNDFMDS.DEMDFNFDS- A0A3M0INX4.1/472-512 QDRFPADLD..LDM...FNGSL..ECDVESIILNDFMDS.DEMDFNFDS- R4GI92.3/541-581 QDRFPADLD..LDM...FNGSL..ECDVESIILNDFMDS.DEMDFNFDS- O43524.1/604-644 HEKFPSDLD..LDM...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- Q9WVH4.1/603-643 HDKFPSDLD..LDM...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- D3ZBQ1.1/603-643 HDKFPSDLD..LDM...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- A0A401NLM9.1/544-584 QDKFPTDLD..LDM...FHGSL..ECDVESIILNEFMDS.EELDFNFDC- F1NNE8.4/591-631 HEKFPSDLD..LDI...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- M7CBF5.1/413-453 HDKFPSDLD..LDI...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- A0A3M0L171.1/351-391 HEKFPSDLD..LDI...FNGSL..ECDMESIIRSELMDA.DGLDFNFDS- M7BPJ1.1/358-398 QDRLPTDLD..VDM...YMENL..ECDVDYIINSDLMDG.EGLDFNFEP- A8MYZ6.1/431-470 -DRFPADLD..LDM...FSGSL..ECDVESIILNDFMDS.DEMDFNFDS- Q70KY4.1/498-537 -DRFPADLD..LDM...FSGSL..ECDVESIILNDFMDS.DEMDFNFDS- Q5TYS1.2/585-624 -DRFPSDLD..LDI...FNGSL..DCDVDSIIRSELMDS.DGLDFNFDA- A0A401NUM2.1/608-647 QERLPSDLD..-DM...FIERL..DCDVESIIRNDLMDG.DTLDFNFDC- M7B761.1/341-380 QEKLPSDLD..-DM...LIERL..DCDMESIIRNDLMDG.ETLDFNFDS- A0A3M0K431.1/413-452 QEKLPSDLD..-DM...LIERL..DCDMESIIRNDLMDG.ETLDFNFDS- A0A1D5PUG9.2/667-706 QEKLPSDLD..-DM...LIERL..DCDMESIIRNDLMDG.ETLDFNFDS- F1R3E6.2/562-602 QDRLPTDLD..IDM...FTENL..DCDVEYIINSDLMDG.DLVDFNFDP- G3V7R4.1/589-627 QEKLPSDLD..-GM...FIERL..DCDMESIIRNDLMDG.DTLDFNFD-- Q9R1E0.2/592-630 QEKLPSDLD..-GM...FIERL..DCDMESIIRNDLMDG.DTLDFNFD-- Q12778.2/595-633 QEKLPSDLD..-GM...FIERL..DCDMESIIRNDLMDG.DTLDFNFD-- A0A0R4IU78.1/526-568 HERLPADLD..MDV...FYSSL..DCDMESILLHDIMDSgEEIDFNFDSS A0A3M0JHY2.1/472-511 QDRLPTDLD..IDM...YMENL..ECDMDYIINSELMDG.-GLDFNFEP- D3ZV21.3/498-534 -DRFPADLD..LDM...FSGSL..ECDVESIILNDFMDS.DEMDFN---- F1R4K6.1/639-680 QNRLQSELE..MDV...HQSSL..DCDVESILLNDFMDStEGMDFNFDG- A0A096MJF0.1/409-448 HDRMPQDLD..LDM...YMENL..ECDMDNII-SDLMDG.EGLDFNFEP- A3RK74.1/592-631 -EKLPSDLD..-GM...PIERF..ECDVESILHDTLMDG.ESLDFNFDPM Q9WVH3.1/464-503 HDRMPQDLD..LDM...YMENL..ECDMDNII-SDLMDG.EGLDFNFEP- D4A433.1/464-503 HDRMPQDLD..LDM...YMENL..ECDMDNII-SDLMDG.EGLDFNFEP- T1KRC7.1/551-593 -NPLPNDLD..LNMd.sLQGGL..ECDVDQVIRHELSVE.GNLDFNFESM P98177.5/463-503 QDRMPQDLD..LDM...YMENL..ECDMDNII-SDLMDEgEGLDFNFEP- A3RK75.1/568-609 -ERLPSDLD..-DM...LIDQLdvECDVERVLHDTLMDG.DALDFNFDPM A0A087T3Q5.1/382-421 --SLPQDLD..FEP...LPGGL..ECDVDQVIRHELSVD.GNLDFNFDPS A0A3S3PHI9.1/355-396 -NPLPNDLD..LNFd.sLHGGL..ECDVDQVIRHELSVD.GNLDFNFDP- A0A401PH21.1/533-572 -ENFPRDLD..LDM...FMESL..DCDVDYIIDHDLMDD.EGLDFNLEP- B7P1M4.1/605-646 -DPLPHDLD..LDLd.aVQG-L..HCDVDQVIQHELNVD.GNLDFNFDSH Q5I0F7.1/574-615 QDRFSSDLD..LEA...FSGSF..DCDMDIITRNDLMDA.EGLELSFDSH A0A2B4T0A6.1/502-540 -EKFPSDLE..LDA...FHGGL..DCDIESIIYDELNMGdGGFDINL--- A0A1V9X2U6.1/343-371 ---------..-DT...LQGGL..ECDVEQVVRHELSVH.GSLDFNF--- A0A0L8FKX9.1/619-657 ----PCDID..YEMl.wSSTNL..ECDVAAVIQHELSLN.ENLDFNFDP- A0A2C9K2G8.1/569-605 ---MPIDID..VDL...LGG-L..DYDMDQVIKQELTLE.GNLDFNFDA- E9H1R6.1/472-511 ---MPNDLD..LNLd.sLQGGF.eDCNVDEVIKHELSMD.GSLDFNFS-- A0A3M0IXB3.1/42-63 QDRFPADLD..LDM...FNGSL..ECDTE----------.---------- A0A158NW12.1/348-383 ------DLN..INIe.aMHGGF..DCNVEEVIRHELSMG.GTLDFNFQ-- A0A1S3ITK5.1/441-480 ---FPNDID..LTLdslQAEGI..ECDVDQVIRQELSID.GNLDFTFD-- A0A2J7QJ15.1/314-350 -----DDLN..LNIe.tLHGGF..DCNVEEVIKHELSMD.GSLDFNFS-- A0A4C1WZN2.1/416-450 ---LSEDLN..LNL...EH-SF..DCNVDEVIKHELSMD.GSLDFNF--- E0VI93.1/289-323 ------DLN..LNIe.tFHGGF..DCNVDEVIKHELSMD.GSLDFNF--- H9JEZ7.1/280-315 ---LVEDLN..FEA...LEHGF..DCNVDEVIKHELSMD.GSLDFNF--- A0A1D2MQT7.1/451-485 ----SSDLD..FNI...ELGQF..DCDVDEVLQTELNLG.GDIDFNF--- A0A482X4H3.1/351-385 -----DDLN..LNIe.tFD-GF..ECNVDEVIKHELSME.GSLDFNF--- A0A0V1FDU9.1/653-690 --QLPTELS..-EM..mYDSEI..QCDIDQVIRHELNIA.GNLDFSVD-- A0A077ZAS8.1/567-604 --QLPSELS..-DM..mYDTDI..QCDIDQVIRHELNIA.GNLDFSAD-- A0A210PR00.1/612-638 ---------..---...-D--L..GCDMEQVLQHELSLE.GNLDFNFDTM A0A2T7P602.1/540-575 ----PLDID..MES...LI-AV..DYDMDQVIKQELSLE.GSLDFDFAS- A0A1D1W9E8.1/465-505 --AFPADLDscMET...LQPGL.sDVDVDAVLNLEMSME.GNLDFNFD-- //