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0  structures 362  species 0  interactions 367  sequences 4  architectures

Family: AIM5 (PF17050)

Summary: Altered inheritance of mitochondria 5

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Altered inheritance of mitochondria 5 Provide feedback

AIM5 (also known as Mcs12 and Mic12) is a fungal mitochondrial inner membrane protein. It is a component of the mitochondrial inner membrane organising system (MINOS/MitOS), which promotes normal mitochondrial morphology [1, 2, 3, 4].

Literature references

  1. Hoppins S, Collins SR, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman JS, Nunnari J;, J Cell Biol. 2011;195:323-340.: A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. PUBMED:21987634 EPMC:21987634

  2. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J;, J Cell Biol. 2014;204:1083-1086.: Uniform nomenclature for the mitochondrial contact site and cristae organizing system. PUBMED:24687277 EPMC:24687277

  3. Huynen MA, Muhlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U;, Biochim Biophys Acta. 2016;1863:91-101.: Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. PUBMED:26477565 EPMC:26477565

  4. Zerbes RM, van der Klei IJ, Veenhuis M, Pfanner N, van der Laan M, Bohnert M;, Biol Chem. 2012;393:1247-1261.: Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. PUBMED:23109542 EPMC:23109542


This tab holds annotation information from the InterPro database.

InterPro entry IPR031463

Mic12, also known as Aim5, is a subunit of the MICOS complex, a mitochondrial inner membrane complex that functions as a primary determinant of mitochondrial inner membrane structure [PUBMED:25918844].

Yeast MICOS complex is comprised of six core subunits: Mic60, Mic10, Mic19, Mic27, Mic26, and Mic12. The MICOS complex can be divided into two independent subcomplexes: Mic27/Mic10/Mic12 and Mic60/Mic19 according to their dependence of respiratory complexes and the mitochondrial lipid cardiolipin. The dependence of the Mic27/Mic12/Mic10 subcomplex on respiratory complexes suggests that in addition to the roles in cristae biogenesis, this subcomplex coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture [PUBMED:25918844].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan MICOS (CL0683), which has the following description:

Mitofilin proteins are crucial organizers of mitochondrial architecture. They are located in the inner mitochondrial membrane and interact with several protein complexes of the outer membrane, thereby generating contact sites between the two membrane systems of mitochondria. They are part of hetero-oligomeric protein complexes that have been termed the mitochondrial inner membrane organizing system (MINOS), alternatively, mitochondrial organizing structure (MitOS) or mitochondrial contact site (MICOS) complex [1]. MICOS interacts with components of the sorting and assembly machinery (SAM) complex of the outer membrane to form the mitochondrial intermembrane space bridging (MIB) complex [2].

The clan contains the following 2 members:

AIM5 QIL1

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(108)
Full
(367)
Representative proteomes UniProt
(517)
NCBI
(497)
Meta
(0)
RP15
(56)
RP35
(165)
RP55
(259)
RP75
(369)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(108)
Full
(367)
Representative proteomes UniProt
(517)
NCBI
(497)
Meta
(0)
RP15
(56)
RP35
(165)
RP55
(259)
RP75
(369)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(108)
Full
(367)
Representative proteomes UniProt
(517)
NCBI
(497)
Meta
(0)
RP15
(56)
RP35
(165)
RP55
(259)
RP75
(369)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PHMMER:C7GMW8
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Llagostera M , El-Gebali S
Number in seed: 108
Number in full: 367
Average length of the domain: 64.70 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 33.58 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.8 26.8
Trusted cut-off 26.8 27.0
Noise cut-off 26.7 26.7
Model length: 61
Family (HMM) version: 5
Download: download the raw HMM for this family

Species distribution

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