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0  structures 28  species 0  interactions 36  sequences 2  architectures

Family: MPS2 (PF17060)

Summary: Monopolar spindle protein 2

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Monopolar spindle protein 2 Provide feedback

Is a fungal transmembrane protein which is part of the component of the spindle pole body (SPB) required for the insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication [1,2,3,4,5,7,8]. It seems that Mps2-Spc24 interaction may contribute to the localisation of Spc24 and other kinetochore components to the inner plaque of the SPB [6].

Literature references

  1. Winey M, Goetsch L, Baum P, Byers B;, J Cell Biol. 1991;114:745-754.: MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. PUBMED:1869587 EPMC:1869587

  2. Schutz AR, Giddings TH Jr, Steiner E, Winey M;, J Cell Biol. 1997;136:969-982.: The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication. PUBMED:9060463 EPMC:9060463

  3. Munoz-Centeno MC, McBratney S, Monterrosa A, Byers B, Mann C, Winey M;, Mol Biol Cell. 1999;10:2393-2406.: Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. PUBMED:10397772 EPMC:10397772

  4. Schramm C, Elliott S, Shevchenko A, Schiebel E;, EMBO J. 2000;19:421-433.: The Bbp1p-Mps2p complex connects the SPB to the nuclear envelope and is essential for SPB duplication. PUBMED:10654940 EPMC:10654940

  5. McBratney S, Winey M;, Genetics. 2002;162:567-578.: Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. PUBMED:12399372 EPMC:12399372

  6. Le Masson I, Saveanu C, Chevalier A, Namane A, Gobin R, Fromont-Racine M, Jacquier A, Mann C;, Mol Microbiol. 2002;43:1431-1443.: Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication. PUBMED:11952896 EPMC:11952896

  7. Jaspersen SL, Martin AE, Glazko G, Giddings TH Jr, Morgan G, Mushegian A, Winey M;, J Cell Biol. 2006;174:665-675.: The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. PUBMED:16923827 EPMC:16923827

  8. Araki Y, Lau CK, Maekawa H, Jaspersen SL, Giddings TH Jr, Schiebel E, Winey M;, Mol Biol Cell. 2006;17:1959-1970.: The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. PUBMED:16436507 EPMC:16436507


This tab holds annotation information from the InterPro database.

InterPro entry IPR031433

Monopolar spindle protein 2 (Mps2) is a fungal transmembrane protein localised to the spindle pole body (SPB) [PUBMED:10397772]. It is required for the insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication [PUBMED:10654940, PUBMED:1869587]. The interaction between Mps2 and Spc24 may contribute to the localisation of Spc24 and other kinetochore components to the inner plaque of the SPB [PUBMED:11952896].

Gene Ontology

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Domain organisation

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Alignments

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(4)
Full
(36)
Representative proteomes UniProt
(60)
NCBI
(79)
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RP35
(16)
RP55
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RP75
(37)
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  Seed
(4)
Full
(36)
Representative proteomes UniProt
(60)
NCBI
(79)
Meta
(0)
RP15
(4)
RP35
(16)
RP55
(24)
RP75
(37)
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  Seed
(4)
Full
(36)
Representative proteomes UniProt
(60)
NCBI
(79)
Meta
(0)
RP15
(4)
RP35
(16)
RP55
(24)
RP75
(37)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Family
Author: Llagostera M
Number in seed: 4
Number in full: 36
Average length of the domain: 254.60 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 91.39 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.9 27.7
Noise cut-off 26.3 26.2
Model length: 372
Family (HMM) version: 4
Download: download the raw HMM for this family

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