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9  structures 160  species 0  interactions 168  sequences 4  architectures

Family: Tom6 (PF17112)

Summary: Mitochondrial import receptor subunit Tom6, fungal

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Mitochondrial import receptor subunit Tom6, fungal Provide feedback

Tom6 is the Tom6 subunit of the protein translocase complex TOM in fungi. This complex of the outer membrane of mitochondria is the entry gate for the vast majority of precursor proteins that are encoded by nuclear DNA, synthesised in the cytosol and imported into the mitochondria. Tom6 and Tom7 together play a role in the assembly, stability and dynamics of the TOM complex [1,2,3,4].

Literature references

  1. Kassenbrock CK, Cao W, Douglas MG;, EMBO J. 1993;12:3023-3034.: Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. PUBMED:8344244 EPMC:8344244

  2. Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT;, Nat Struct Biol. 2001;8:361-370.: Multistep assembly of the protein import channel of the mitochondrial outer membrane. PUBMED:11276259 EPMC:11276259

  3. Harner M, Neupert W, Deponte M;, EMBO J. 2011;30:3232-3241.: Lateral release of proteins from the TOM complex into the outer membrane of mitochondria. PUBMED:21765393 EPMC:21765393

  4. Wenz LS, Opalinski L, Schuler MH, Ellenrieder L, Ieva R, Bottinger L, Qiu J, van der Laan M, Wiedemann N, Guiard B, Pfanner N, Becker T;, EMBO Rep. 2014;15:678-685.: The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. PUBMED:24781695 EPMC:24781695

This tab holds annotation information from the InterPro database.

InterPro entry IPR020266

Translocation of preproteins across the mitochondrial outer membrane is mediated by the translocase of the outer mitochondrial membrane (TOM) complex. Tom6 and Tom7, two small subunits of the TOM core are in direct contact with the major component of the pore, Tom40. In addition, Tom6 interacts with Tom22 in a manner that depends on the presence of preproteins in transit [ PUBMED:11278536 , PUBMED:21765393 , PUBMED:24781695 ].

Gene Ontology

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Domain organisation

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Seed source: Phmmer:P33448
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 17
Number in full: 168
Average length of the domain: 38.4 aa
Average identity of full alignment: 44 %
Average coverage of the sequence by the domain: 54.17 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 18.8 18.8
Trusted cut-off 18.8 18.9
Noise cut-off 18.7 18.7
Model length: 45
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Tom6 domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A1D8PJC1 View 3D Structure Click here
C0NB63 View 3D Structure Click here
C1H7W1 View 3D Structure Click here
P33448 View 3D Structure Click here