# STOCKHOLM 1.0
#=GF ID Rh5
#=GF AC PF18515.2
#=GF DE Rh5 coiled-coil domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF GA 26.0 12.0
#=GF NC 25.9 11.9
#=GF TC 27.5 12.8
#=GF SE ECOD:EUF04827
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Coiled-coil
#=GF RN [1]
#=GF RM 25296023
#=GF RT Crystal structure of PfRh5, an essential P. falciparum ligand
#=GF RT for invasion of human erythrocytes.
#=GF RA Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Lawrence MC,
#=GF RA Cowman AF;
#=GF RL Elife. 2014; [Epub ahead of print]
#=GF DR INTERPRO; IPR041668;
#=GF DR SO; 0001080; coiled_coil;
#=GF CC This is a helical coiled-coil domain found in
#=GF CC reticulocyte-binding protein homolog 5 (RH5), a Plasmodium
#=GF CC falciparum protein essential for erythrocyte invasion [1].
#=GF SQ 27
Q7RBZ1.1/189-441     -RSKHYNAYNDIQTAIKECEPQKNKVINEMFNFQSPLYEFYKN.PMHDYYIPYEDSKSQYVNCMIPRFKKLELKVDNSFLSVVP.EYDHLAYYENRNVDVIYKKYATNTKNHMIFQLGTIN.KYPMFSDKETIPYIKSLIQILESE.NAQASLKKKLFFLEKQFEDIIDKSNKSRVKCIRAYQYMQKYQLDGTF-IR.YYYNYFPEFKKIATHKAIFIYNS.GNLQSMESVYKYQKEVLNRFIKTLGKLLIEKPDPDNNQI
Q7RPU0.1/192-444     -LNKLKQIQKDIIAIKKECEPRRTNVIGEMVKIQDPLYEFYKE.PIHSYYNSYEISKKDYVNCILPRFKNLEPILDGILSSLKL.EYDYVGYYSYWDIDAAYKEHATITHKHILAFLNDVK.KHPMPNDKETVPHIKSLIQILESE.GEQKHLKNKLIFLEKQFEDVIHKSSIYLEKCLSSHLLMEDYLKDSKI-SP.YYYEFLEKIKRISKRREIFFYNA.KKLKYLEIVYNHQKEVLNSFVKTLGRLLIEKPDPNNNQI
Q7RJS3.1/176-427     -KKAHDDIYNNIARIKELCEPKKSELIKELDKIHNPFYNFYNN.PPMDDYNSYTTSKTNFISCLTNELEKIKNKPNDIISSEEG.VYKKNCKNNRKLKD-LDKKDSEFCKNVTYLGPSCNR.SWDVPKDNEVIPFINFLITELEKN.NSLKNLVTKLEFIKKQNEDIQNKHNKHIEICKKEEVSVNKCTKTIID-NT.NCDQHFNEIKKIGESYSIIKYNH.TVLEYLESIRLTYKHSLLYFLKLIGDALINKVDSDGNII
Q7RBJ9.1/183-437     IWELYDKVKKKIINVKEECVDKRKKLAQKIDQLQDVVYNYENK.SYQNDYNSLKPITTEFIRCMNDKFKSVSYSISQMSNYADY.VYKYGKLGHHHYMNDNYLIRHKIVTTQFENKLHQIK.KSDILKSGNYVKFIDKVIDIAKKD.EELKNVIDTLNFIKKYIEDITKKFKFYLNKCNGAQSQLIEIEMKAKKNKY.TRYEVINKIQSLANVYGHFNVNY.ENMIDLETVYNNKIQAFKNVLNFIPHILIGKVDTCTNHV
Q7RGA9.1/192-443     IKTDQNVVINDVRQTNASCYSEKNELINKLGNIHNPFYNFHND.RSIDDYNLYTSSKNNFVNCLKKGFENIKKKTNDIISYEEK.LYTDKCKNSSKLKNT-TKKPSEFCKNVMNLNVSRKN.SWEVPKNNEIISFIDFLIEKLKSN.NYPMTLVTKLDFIKKQFEDIKNKHNKHIKICKQEEIVVNKCTNNID--NN.NCDKHFNEIKKIAESYSIIFYNY.TILENLESVNITYKESLDYFFNSLGKLLINKVDSDGNII
Q7RFQ7.1/102-357     IWDKVASYSEKIKNFENSCEEMKKDLSMAIENLENPAYNYQNQ.NFQNTYSLLKTKRTNLVQCIKSKFNTLNNDINEIKKYDKYdMYNVMSINTPLTLAPVYNSRIDLVKNEINNDFEKIK.KLSINEVKNVSNFINEIANIVEIE.SELKANLDTIKFMQKEINHIIKLYEKHTKIYTTKYNVIMGLQHIDNPYKT.YTNNVINSISGLGDDYAIFKFSY.NILINLDKLYNTKKTQINNIFNFLTQILIGKLDPSSNRI
A5K940.1/215-470     YNPQIQHISQIVRKNVDICSNHLKELYTTVYRLENPERHKFQRaHYSNERNEYRKRLASFHVCLRLIHRKNYRAITYAELIILNtLDSISCNWDNNCSTNIYANILKTYMSEISNFEKKKK.NDAINKINNIYKSAVDAITKIKSE.LTPSVTSDTADFVLDEIKYIIDKINIHLEKIKYGSEYVKYINSEKIPQQY.KKDDLKSHYVVLVTHYSAFLFST.KHINVLEDVFKNKERILYDVFGKIESALRNKLTTLIDS-
A5K696.1/164-419     YDPQIDKVFKAAEKNGFVCENDINNLYNIVTHLENPEHYKNKRyNYSKDREKFQKQLSSVHGCLLTNHKQNYKDMIYADTTIFDyLHYIYCYPEDKCSSKYYRDMLNISMGKINEYEQKKK.NEAINKIIDVHETGAYVMRKIKEE.LNPSLNSDVADFVIDEIKYIIERLNAHSEKIKCASDFIKHIYKEKVQNEI.SKNELESNYIVLSIHHGSFRFST.EHVIMLEEIFKSKEQILHNICSKFLNELKNKITALINS-
A0A509AKC9.1/196-445 ----RNLVLDDVIQTNNSCNDKKQELINQIDNIHNPLYNFYNN.PPMDDYKLYTTSKTNFVNCLKSEFEKIKEKPNNIISYEED.VYKKNCKNSSKLKNR-PQNNSECFKNVMYFGSNYKR.DWEVPKDNETIPFIDFLIKELKQN.NNLKTLVTKLEFIKKQIEDIKNKHNKHIEICKKEEDSVKKCINTINNNNN.NCDKYFNEIKKIAESYSIMRYNN.TIIENLESIRITYKDSLIHFFKSLGNLLINKVDSDGNII
A0A509AJ95.1/192-444 INKDHDEVLNDVIETKKSCNTEKMELINRLSNIHNSFYNFYND.PSKDDYNLYTLSKTNFVNCLKNGFEKVKNKPNDIISYEEK.VYKEKCKNSSKLNNN-TQKNYEFCKNVMHLNSFRKQ.NWEVPQDKEIIPFIDFLINELKQN.NNLKTLVTKLEFIKKQFEDIKNKHDKHIKICKKEEAFVNKCTNTTID-NK.NCAKYFNEIKKMAEAYSILDYNY.TIIENLESIRITYNNSLIYFFKSLGELLINKVDSDGNII
A0A509AJA4.1/195-444 --KDRDMVLDDAIQTNNSCNDKKQELINQIDNIHNPLYNFYNN.PPMDD-NSYTTSKTNFVNCLKNGFEKIKNKPNDIISYEEK.VYKENCKNSIQLKN-LPQNNSEFCKNVMYLNSSREK.NWEVPKDKEIIPFIDFLIKELEQN.NNLKTLVPKLEFIKKQFEDIKNKHDKYIKMCKEKEVFVKKCTNTTID-NK.NCDKNFNEIKKIAESYSILDYNY.TIIENLESIYITYKYSLLYFFKSLGKLLINKVDSDGNII
A0A509AKA9.1/192-444 INKDNDEVLNDVIETKKSCNTEKMELINRLSNIHNSFYNFYND.PSKDDYNLYTLSKTNFVNCLKNGFEKVKNKPNDIISYEEK.VYKEKCKNSSKLNNN-TQKNYEFCKNVMHLNSFRKQ.NWEVPQDKEIIPFIDFLINELKQN.NNLKTLVTKLEFIKKQFEDIKNKHDKHIKICKKEEAFVNKCTNTTID-NK.NCAKYFNEIKKMAEAYSILDYNY.TIIENLESIRITYNNSLIYFFKSLGELLINKVDSDGNII
Q7RQB6.1/184-435     --SKHYHAHNDIQKAIKECEPLKKKVINEMFNFQSPLYEFYKE.PVHGYYDPYAYSQFYYANCMVPQFKKLEPVVEKAFSSMMP.EYDYLCYYEYWNVDAIYKNYSTTTKDYMVFQMEIIK.KYPMFSDNETVPYIKSLIKILESE.NEQASLKKKLFFLEKQFEDIISKSYKCRTHCVNSYQYMQDYVLNETY-TQ.YYYNYLKELKKIAASKALFIYNS.DNLQSMEKVYNYQKEVLNRFIKTLGKLLIEKPDPDNNQI
A0A509ACP7.1/194-443 -NNNHDTVLNDVIETNKSCNDKKQELINQIDNIHNPLYNFYNN.PPMDD-NSYTTSKTNFVNCLKNGFEKIKNKPNDIISYEEK.VYKENCKNRIQLKN-LPQNNSEFCKNVTHLAPIYKI.NWEVPKDNETIPFIDFLIKELKQN.NNLKTLVTKLEFIKKQFEDIKNKHNKHIEICKKEEVSLKKCINTIN--NN.NCDKYFNEIKKIAESYSILYYNY.TIIENLESIRITYNNSLIYFFKSLGELLINKVDSDGNII
Q7REY3.1/176-427     -KKDHDEVYNDIIRIKELCKPKKLELISEINKMHDPFYNFYND.PPMDDYKSYTASKTDYLNCLKDEFEKIKNKPNNIISYEKD.VYIKKCKNSIKLKD-LSKKDSGFCKNVTHLGPKCNR.DWEVPKDKEVVPFIDFLITEIKKI.NNLKTLVTKLEFMKKQLADIISKHNKHIEICKKEEASVNTCTKNNID-NN.NCNQHFNEVKKIGDSYSILEHNH.KVLEYLESIRIGFKDSVIYFFKLIGELLIKKVDSNGNII
A0A509APQ0.1/194-445 -NNNHDTVLNEVIETNKSCNDKKQELINRLSNIHNSFYNAYND.PSKDDYNLYTLSKTNFVNCLKNEFEKIKNKPNDIISYEED.VYKNNCKNSSKINSH-PQNNSEFCKTVTRLGSNYER.DWKVPKDNEVIPFIDFLINELKQN.NNLKTLVPKLEFIKKQFEDIKNKHDKYIKMCKEKEVFVKKCTNTTID-NK.NCDKHFNEIKKIAESYSILDYNY.TILENLESISITYKYSLIHFFKSLGGLLIDKVDSNENII
A0A509AH40.1/174-428 IWGKLANYSKKIKNFENSCEEIKKELSMVIENLENPIYNYQNQ.NFQNAFSLLKKKRADLIQCIKSKYSTLNNDINEIKKNDNYyMYNVMRINPPLTLVPVYNIRIDLIKNEI-NDLKKIT.KLPLNEVKNVSNFINQITNIVENE.PELKNNLDTIKFMQKEINHIIKLYEKHTNICNIKYNIIMGLQKIDNAYKT.HTYHVINNIFDLGNNYAIFKYSY.NILTNLDKLYNNKKTQINNIFNFLTQILIGKVDPSSNKI
Q7RMS4.1/61-312      -KKDHDQVFNKIAITNRLCITERNELINQMGNIHNPLYNFYNN.PPMDDYNLYKSSKTKFVNCLKNNFENIKNEINNVISSEET.LYKTECKNSNNLKSS-TQKDSGFCKNVISIGITYKK.KSDIPNDNDIIPFIDFLIEKLKPK.DDLKSLIIKLNFIKEQFKDMKNKHDKYTKICQKEEASVKKCNEPDLN-NN.NCGNYFNDFKKKADSYSILDYND.KIIQNLEAIYYTYKESLEYFFKSIGELLIDKPDSNGNII
Q7RBM0.1/1-193       -------------------------------------------.-------------------MNDKFKSVSYSISQMSNYADY.VYKYGKLGHHHYMNDNYLIRHKIVTTQFENKLHQIK.KSDILKSGNYVKFIDKVIDIAKKD.EELKNVIDTLNFIKKYIEDITKKFKFYLNKCNGAQSQLIEIEMKAKKNKY.TRYEVINKIQSLANVYGHFNVNY.ENMIDLETVYNNKIQAFKNVLNFIPHILIGKVDTCTNHV
A0A509AGK9.1/184-439 IWKSYGQVNREIRNAEEECVDKRKKLAHKIDQLQDAIYNYENK.PNQDDDKTLKQITTEFIHCINDKFKTVYPSIFYMSNYADF.VYRSVNLGHPHYMDLCYEIRHKIVKTEFNNKLNRIR.NPAILKSDEYVNLINKVIEIANKN.EELKNVIYPLNFIKKYIEDIRKKYNSCITKLNSANAQLIVIEINAKKMNYsNKSKSIKRITDLANAYADFNINY.KNIIDLESVYNNKIQAFNNVLNFIPHILIGKIDICTNHV
A0A509AHF6.1/183-438 IWKAYDQVNREIRNAEEECVDKRKKLAHKIDQLQDVIYNYKNK.PNKDDDKTLKQITTEFIHCMNDKFITVYPSIFYMKNYADF.VYHSVKLGTARYMDLCYEIRYKIVKTEFDNKLNRIR.KSAILKSKEYVDLINKVIEIANNN.EELKNVIYPLNFIKKYIEDIRKKRESFIIMLNTAYTLLIGISINTKKMNYsSKHESIKRITELADAYAYFNVNY.KNIIDLESVYNNKIQAFNNVLNFMPHILIGKIDICTNHV
Q7RAW8.1/191-431     -KKDHDQVFNKIAITNGSCITERDELIKQMGNMHNPLYNFYNN.PPMDDYNLYKSSKN-----------NIKDELNNIISSEQK.LYKMECTS-NKKFHTITQKYSEFCKNTMNIGVTYKK.KSEIPNDNDTIPFIDFLIEKLELK.DYLKGIAIKLKFIKEQFKDIKNKYEKHIKIYEKEDASVKKCTEPTFI-DN.NCDNHFNNFKTRAESYGILDYNG.SIIQNLEAIYYTYVESLDYFFKSIGEILIDKPDSNGNII
A0A509ADY2.1/200-449 --NKHHQINNELNEIFKKHQASRDKVITEMANLHNPLYNFYNN.PPMDNYKLYTSSQKKYVNDLISALRKVESQIEKTTSSMSN.TYINLTKNKANELKDIRKKYTDDVMNYNNKILGLIK.NRSFLNDDKTIPFIEFLINTLKSK.NKLPSIQNKLKFLLNQFRDAREKYSWHKNICEIVHIFMVKFIKDGY--SY.SNNQYFNDLKLIASKRAILIYND.NRLKSLEELYKYLKEVLFHIFKMLGRILIDNPDPQNNL-
Q8IFM5.1/210-249     ----IKKINETYDKVKSKCNDIKNDLIATIKKLEHPYDINNKN.-D--------------------------------------.------------------------------------.------------------------.--------------------------------------------------.-----------------------.---------------------------------------
Q8IFM5.1/296-506     ----------------------------------------MNR.TFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNlFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNlNKDLSDMTNILQQSELLLTNLNKK.MGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTF.QKDELLKRILDMSNEYSLFITSD.HLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFN------
A0A3Q9HNQ9.1/557-645 -------------------------------------------.----------------------------------------.------------------------------------.------------------------.EAAQDITSLIKTIQDEIRLVVENVNKSRGIVDEQSQVVKETENYFKNIAN.ENNQVLEKIKSIADIVQIIKANNqEVLSHMEKVYSMAEE------------------------
A0A2G8LN69.1/27-91   -------------------------------------------.----------------------------------------.------------------------------------.---INRIEHLINRIEYLINRIEYLiNRIEHLINRIEYLINRIEYLINRIEYLINRIEYRINMIEYLIN-------.-----------------------.---------------------------------------
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