# STOCKHOLM 1.0 #=GF ID CoV_NSP2_N #=GF AC PF19211.2 #=GF DE Coronavirus replicase NSP2, N-terminal #=GF AU Chuguransky S;0000-0002-0520-0736 #=GF GA 29.7 29.7 #=GF NC 27.3 29.6 #=GF TC 30.1 35.9 #=GF PI Corona_NS2_N; #=GF SE Bateman A #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 16227261 #=GF RT The nsp2 replicase proteins of murine hepatitis virus and severe #=GF RT acute respiratory syndrome coronavirus are dispensable for viral #=GF RT replication. #=GF RA Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR; #=GF RL J Virol. 2005;79:13399-13411. #=GF DR INTERPRO; IPR043615; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This entry corresponds to the N-terminal region of coronavirus #=GF CC non-structural protein 2. NSP2 is encoded by ORF1a/1ab and #=GF CC proteolytically released from the pp1a/1ab polyprotein. The #=GF CC function of this protein is uncertain. This region contains #=GF CC numerous conserved and semi-conserved cysteine residues. #=GF SQ 84 B1PHJ3.1/112-318 -SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGDN...........ITVNGQAYHKA.......WNVTRG.DVPYQFQNASTILSIEYL-...ADEKHVL..PDGAVAKSAKPPKFSKNIVLSEKYKALYDACGNPFVTNgtnvlevvTNPIFAHGFVQCK-CGSKHWTTGDWA.GFKSVCCGIPG.RVLCT..-VFGGVAPGSV-..........................LLTSTRVDAspgATRY...YHGLTLKHI......CNVDGVACW B1PHJ4.1/112-318 -SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGDN...........ITVNGQAYHKA.......WNVTRG.DVPYQFQNASTILSIEYL-...ADEKHVL..PDGAVAKSAKPPKFSKNIVLSEKYKALYDACGNPFVTNgtnvlevvTNPIFAHGFVQCK-CGSKHWTTGDWA.GFKSVCCGIPG.RVLCT..-VFGGVAPGSV-..........................LLTSTRVDAspgATRY...YHGLTLKHI......CNVDGVACW A0A0U1UZ20.1/115-316 --VYVDNYMCGANGKPVLPADVWVFQD...YFGDETE-...........LIVNGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL-...TDIPHTL..RSGSKLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstlreavPKPVFAHAYVACK-CGRKSWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITTSSVGS...GTRY...YNGLTVKHV......VTVDGLACW B1PHK1.1/115-316 --VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE-...........LIVNGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL-...TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstlreavPKPVFAHAYVACK-CGRKAWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITTSSVGS...GTRY...YNGLTVKHV......VTVDGLACW B1PHK0.1/115-316 --VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE-...........LIVNGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL-...TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNgstlreavPKPVFAHAYVACK-CGRKAWSVGDWS.GYKSTCCGVFG.KPQCV..-VFGEVVPGDV-..........................FITTSSVGS...GTRY...YNGLTVKHV......VTVDGLACW P0C6U2.1/112-316 NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE-...........IIINGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYVH...GDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsnileafTKPVFISALVQCT-CGTKSWSVGDWT.GFKSSCCNVIS.NKLCV..-VPGNVKPGDA-..........................VITTQQAGA...GIKY...FCGMTLKFV......ANIEGVSVW A0A0U1WHD1.1/115-316 --VYVDNYMCGANGKPVLPADVWCFQD...YFGDETE-...........LVVNGVRHVKA.......WDVVRT.NLPYQFQSTGAIESIIWL-...SDVPHVL..RNGSKLSVCKAPKFSKNVKLSEPLNTLYQACGSPFVSNgtdlagavGKPVFAHSYVACK-CGSKCWSVGDWS.GYKSTCCGTFG.KVLCT..-VFGDVVPGDV-..........................LMTSAAVGS...GTRY...YNGLTIKHV......VTVQNIACW P0C6X1.1/112-316 NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE-...........IIINGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYVH...GDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNgsnileafTKPVFISALVQCT-CGTKSWSVGDWT.GFKSSCCNVIS.NKLCV..-VPGNVKPGDA-..........................VITTQQAGA...GIKY...FCGMTLKFV......ANIEGVSVW A0A0U1UZC3.1/114-317 --IYVDNYLCGADGTPVVQESMWSYTD...HFGEDCDE...........ITLCGITYVHA.......WNVQRA.DVPYEQQNVTSIFSIEYL-...LDVDHAL..QNGAVLNVASGVKYKKSVVLSEGFKKLYDACGVPAVQNgntlvdilTKPAFFHAIVSCS-CGLSSYTVGDWKiGFRSLCCGKRL.EPITV..-VVGDVKPGDI-..........................VVTSANAGD...GVRY...FNGLTLQYV......GDWEGVSCW S5Z1D1.1/111-314 NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ-...........VVVNGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC-...AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNgdtlasilTEPVFLHALVKCT-CGKTMWTVGDWS.CYKSLCCGVVC.KPLCN..-VAGIVNPGSA-..........................VVTRTGLGS...GIKY...YCGMFLRHI......LDVDGVSVW S5YAF0.1/111-314 NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ-...........VVVNGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC-...AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNgdtlasilTEPVFLHALVKCT-CGKTMWTVGDWS.CYKSLCCGVVC.KPLCN..-VAGIVNPGSA-..........................VVTRTGLGS...GIKY...YCGMFLRHI......LDVDGVSVW A0A0U1WHG1.1/111-313 --VYVDNYMCDQTGKPVLAADVWTFKD...YFGESDT-...........IVIDGVVYRKA.......WEVVRL.DVPYKAQSVSAISSIEWL-...CGVQHVL..PSGTVLDVAKSVSKSKVVLLSDPYADIYDQVGSPFMTNgknlleivVKPCFLHGYVKCN-CGNTHWAVGDWRaGYKSVCCGLNC.NPICV..-AAGYVEPGDV-..........................LFTSKGAGT...GLKY...YKGLTLKFV......GEVENVAVW A0A0U1WHF6.1/111-315 NVVFVDNYMCGADGKPAVPREQWSFEE...HFDDDTED...........IIINGVTYRHA.......WNTIRA.DDPYEKQGLLSIKSIEYV-...STIPHKL..PNGSVLSVAGPPKKRKAVVLDEKYNKIYNACGVPFVTNgksisevvTKPLFLHALVKCK-CGNESWTVGDWT.GFKTTCCGATG.KVTTF..-AVGDVTPGDI-..........................VFTTTGAGT...GTKF...FCGLVLTHV......DTLEGVSAW A0A023YA54.1/197-445 -FIPIDQFMCGKDGAPVPDYATLAASEnliSLADVATDvsara.dsdgyIDFKSKLYRIV.......WHVERK.NVPYAKQTIFTINSVVQCDgiqDVPPHTF.tLGGKVDLIVPRNKWTGKTALNLKQKILYTFYGKDALDN........HSYIYHSAYADCTSCGKGSWLTGNAVqGFACDCGAQYSaNDVEL..QSSGVVNPNAIFcatcpfakgdscsssckhtlaqmvsqLSEKCDVAP..dGKSFtlaFGGVVYAYL......GCLEGTMYF P0C6F6.1/112-320 -TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ-...........FTLNGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI-...TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNgstfvemlKDPAFFHALITCE-CGRSEWTVGDWK.GYNSLCCNIKC.KPITI..-VTPKAVPGAV-..........................VITKAGIGA...GLKC...YNNVFLKHIidlvvpGTNLGWGVW T2B9I2.1/194-443 DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEADvaara.ddegfITLKNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKDgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN........PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSERCNVIA..dSKSFtliFGGVAYAYF......GCEEGTMYF K9N638.1/194-443 DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEADvaara.ddegfITLKNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKDgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN........PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSERCNVIA..dSKSFtliFGGVAYAYF......GCEEGTMYF P0C6W0.1/112-320 -TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ-...........FTLNGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI-...TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNgstfvemlKDPAFFHALITCE-CGRSEWTVGDWK.GYNSLCCNIKC.KPITI..-VTPKAVPGAV-..........................VITKAGIGA...GLKC...YNNVFLKHIidlvvpGTNLGWGVW A0A0U1WHG4.1/111-315 NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE-...........VSIGDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC-...GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTYQKLYDNIGVPFVTNgkvlteiiPKPVFNHGLVKCH-CGKVSWTVGDWS.CYKSTCCGTVC.KPIAI..-VNGDVNPGDV-..........................VITSKQVAT..nGVKY...YNGMVLKYV......DTIEDVHLW A0A0U1UZ30.1/99-303 NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE-...........VSIGDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC-...GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTFQKLYDNIGVPFVTNgkvlteiiPKPVFNHGLVKCH-CGKVSWTVGDWS.CYKSTCCGIVC.KPIAI..-VNGDVNPGDV-..........................VITSKQVAT..nGVKY...YNGMVLKYV......DTIEDVHLW P0C6V2.1/112-310 --IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI-...........IEFEGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN-...LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdclskcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTSMSAGK...GVKF...FANCVLQYA......GDVEGVSIW Q0PKZ7.1/112-310 --IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI-...........IEFEGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN-...LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdclskcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTSMSAGK...GVKF...FANCVLQYA......GDVEGVSIW A0A120I2U3.1/112-310 --IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI-...........IEFEGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN-...LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdclskcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTSMSTGK...GVKF...FANCVLQYA......GDVEGVSIW P0C6Y5.1/112-310 --IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI-...........IEFEGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN-...LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdclskcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTSMSAGK...GVKF...FANCVLQYA......GDVEGVSIW Q0PKZ6.2/112-310 --IYVDQYMCGADGKPVIEG---DFKD...YFGDEDI-...........IEFEGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN-...LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNgdclskcfDTLHFIAATLRCP-CGSESSGVGDWT.GFKTACCGLSG.KVKGV..-TLGDIKPGDA-..........................VVTSMSAGK...GVKF...FANCVLQYA......GDVEGVSIW K9N7C7.1/194-443 DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEADvaara.ddegfITLKNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKDgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN........PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSERCNVIA..dSKSFtliFGGVAYAYF......GCEEGTMYF T2B9U0.1/194-443 DVTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEADvaara.ddegfITLKNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKDgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN........PTYIYHSAFIECGSCGNDSWLTGNAIqGFACGCGASYTaNDVEV..QSSGMIKPNALLcatcpfakgdscssnckhsvaqlvsyLSERCNVIA..dSKSFtliFGGVAYAYF......GCEEGTMYF P0C6T5.1/197-441 -FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAEvksrt.dsdryIVFKNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLDt.mEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE........PNYIYHSAYVDCTSCGKGSWLTGNAVqGFACDCGAHYCaNDVDL..QSSGLVRKNAVLlttcpcnkdge....ckhtlpqlvsmMTDKCDVEV..vGKTFiltYGGVIYAYM......GCSGGTMHF A0A125R5A4.1/112-310 --IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQNLLTIKEIQYN-...LDIPHKL..PNCAIREVAPPVKKNSKVVLSEDYRKLYDIFGSPFMGNgdslnkcfANLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VITSMSAGK...GVKF...FANSVLQYA......GDVENVSVW E3W5H8.1/111-310 -VIYVDQYMCGADGKPVIEG---EFKD...YFGDEDT-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN-...LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNgdslnkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGSVKPGDA-..........................VITSMSAGK...GVKF...FANSVLQYA......GDVENVSVW A3EXD8.1/197-441 -FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAEvksrt.dsdryIVLKNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLDt.mEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE........PNYIYHSAYVDCTSCGKGSWLTGNAVqGFACDCGAHYCaNDVDL..QSSGLVRKNAVLlttcpcnkdge....ckhtlpqlvsmMTDKCDVEV..vGKTFiltYGGVIYAYM......GCSGGTMHF A0A125R5A3.1/112-310 --IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQNLLTIKEIQYN-...LDIPHKL..PNCAIREVAPPVKKNSKVVLSEDYRKLYDIFGSPFMGNgdslnkcfANLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VITSMSAGK...GVKF...FANSVLQYA......GDVENVSVW E3W5H7.1/111-310 -VIYVDQYMCGADGKPVIEG---EFKD...YFGDEDT-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN-...LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNgdslnkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGSVKPGDA-..........................VITSMSAGK...GVKF...FANSVLQYA......GDVENVSVW P0C6W4.1/197-441 -FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAEvksrt.dsdryIVFKNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLDt.mEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE........PNYIYHSAYVDCTSCGKGSWLTGNAVqGFACDCGAHYCaNDVDL..QSSGLVRKNAVLlttcpcnkdge....ckhtlpqlvsmMTDKCDVEV..vGKTFiltYGGVIYAYM......GCSGGTMHF Q98VG9.2/112-310 --IYVDQYMCGADGKPVIEG---EFKD...YFGDEDV-...........IIYEGEEYHCA.......WLTVRD.EKPLWQQTLLTIREIQYN-...LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNgdslntcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................IVTSMSAGK...GVKF...FANSVLQYA......GDVENVSVW A0A059VJE6.1/112-316 -IVPVDQYMCGADGKPVLQESEWEYTD...FFADSEDG..........qLNIAGITYVKA.......WIVERS.DVSYASQNLTSIKSITYC-...STYEHTF..PDGTAMKVARTPKIKKTVVLSEPLATIYREIGSPFVDNgsdarsiiKRPVFLHAFVKCK-CGSYHWTVGDWT.SYVSTCCGFKC.KPVLV..-ASCSATPGSV-..........................VVTRAGAGT...GVKY...YNNMFLRHV......ADIDGLAFW P0C6T4.1/196-440 DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVDvksrm.dsdrfIVLNKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCDd.kDSVPEHTftIGSQILMVSP-LKATNNKNFNLKQRLLYTFYGKDAVQQ........PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPRNALFlancpcannga....cshsaaqvyniLDGKACVEV..gGKSFtltFGGVVYAYM......GCCDGTMYF A3EXA2.1/196-440 DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVDvksrm.dsdrfIVLNKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCDd.kDSVPEHTftIGSQILMVSP-LKATNNKNFNLKQRLLYTFYGKDAVQQ........PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPRNALFlancpcannga....cshsaaqvyniLDGKACVEV..gGKSFtltFGGVVYAYM......GCCDGTMYF P0C6W3.1/196-440 DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVDvksrm.dsdrfIVLNKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCDd.kDSVPEHTftIGSQILMVSP-LKATNNKNFNLKQRLLYTFYGKDAVQQ........PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPRNALFlancpcannga....cshsaaqvyniLDGKACVEV..gGKSFtltFGGVVYAYM......GCCDGTMYF A0A1L2KGB5.1/112-315 -VVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVDN...........ITINGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL-...GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNgsslleilTKPVFFNAFVECN-CGNKGWSVGAWD.GYLSPCCGTPA.KKICV..-VPGNVVPGDV-..........................LVTSTNAGT...GTKY...YAGLVVKHV......VNVSGVSLW K4JZT2.1/112-315 -TVFVDNFLCGANGLPACSEQEWEFKD...YFGELDE-...........VIINGTTFVKA.......WNVDRT.PGPYSTQNLLSINSISWC-...GEIPHSL..ADGSIRRVAKVVKKSKSVLLGKQFQQLYDSVGSPFVTNgknltdvlVKPIYCHALVKCQ-CGKTSWTVGDWS.CYKSMCCGFNC.KPLAI..-VNGEVVPGDV-..........................LVTSDKVSA..sGTKY...YNGMVLKFV......DKIDNACLW C6GH83.1/112-310 --IYVDQYMCGADGKPVIDG---EFKD...YFGDEDV-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN-...KDIPHKL..PNLAIREVAPPVKKNSKVVLSEEYXKLYDIFGSPFMGNgdslnkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VVTSMSAGK...GVKF...FANSVLQYA......GDVENVSVW A0A1L2KGB4.1/112-315 -VVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVDN...........ITINGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL-...GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNgsslleilTKPVFFNAFVECN-CGNKGWSVGAWD.GYLSPCCGTPA.KKICV..-VPGNVVPGDV-..........................LVTSTNAGT...GTKY...YAGLVVKHV......VNVSGVSLW C6GH82.1/112-310 --IYVDQYMCGADGKPVIDG---EFKD...YFGDEDV-...........IIYEGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN-...KDIPHKL..PNLAIREVAPPVKKNSKVVLSEEYXKLYDIFGSPFMGNgdslnkcfDSLHFIAATLKCP-CGAESSGVGDWT.GFKTACCGLHG.KVKGV..-TLGAVKPGDA-..........................VVTSMSAGK...GVKF...FANSVLQYA......GDVENVSVW K4K1U5.1/112-315 -TVFVDNFLCGANGLPACSEQEWEFKD...HFGELDE-...........VTINGTTFVKA.......WNVDRT.PGPYSTQNLLSINSISWC-...GEIPHSL..ADGSIRRVAKVVKKSKSVLLGKQFQQLYDSVGSPFVTNgknlsdvlVKPIYCHALVKCQ-CGKTSWTVGDWS.CYKSMCCGFNC.KPLAI..-VNGEVVPGDV-..........................LVTSDKVSA..sGTKY...YNGMVLKFV......DKIDNACLW U5LR11.1/201-450 DVIPVDQYMCGFDGSPIKPYLDLANKEgltKLADVEADvcsrv.dkqgfLIFKGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRNg.vHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE........PSYIYHSAFVDCVKCNEGKWCTGNAVaGFACECGAAYTaKQVLL..QSSGLVKSNALFcatcpfaqgdrcsldckhtvpqvvsyLSEKCVVFP..sGKSFvlaFGGALYTYM......GCAEGTMYF U5KNA9.1/201-450 DVIPVDQYMCGFDGSPIKPYLDLANKEgltKLADVEADvcsrv.dkqgfLIFKGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRNg.vHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE........PSYIYHSAFVDCVKCNEGKWCTGNAVaGFACECGAAYTaKQVLL..QSSGLVKSNALFcatcpfaqgdrcsldckhtvpqvvsyLSEKCVVFP..sGKSFvlaFGGALYTYM......GCAEGTMYF P0C6F7.1/196-440 DCIPVDQYMCGKNGKPIADYAKIVAKEgltTLADIEVDvksrm.dsdrfIVLNKKLYRVV.......WNVTRR.NVPYSKQTAFTVVSVIQCDd.kESVPEHTftIGSQILMVSP-LKATNNKNFNLKQRLLHTFYGKEAVQQ........PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPKNALFlancpcannga....cshnaaqvysiLDGKACVEV..gGKSFtltFGGVVYAYM......GCCDGTMYF P0C6W1.1/196-440 DCIPVDQYMCGKNGKPIADYAKIVAKEgltTLADIEVDvksrm.dsdrfIVLNKKLYRVV.......WNVTRR.NVPYSKQTAFTVVSVIQCDd.kESVPEHTftIGSQILMVSP-LKATNNKNFNLKQRLLHTFYGKEAVQQ........PGYIYHSAYVDCNACGRGTWCTGNAIqGFACDCGANYSaNDVDL..QSSGLVPKNALFlancpcannga....cshnaaqvysiLDGKACVEV..gGKSFtltFGGVVYAYM......GCCDGTMYF H9EJ42.1/112-315 -VVFVDKYMCGFDGKPVLPKNMWEFRD...YFNDNTDS...........IVIDGVTYQLA.......WDVIRK.DLSYEQQNVLAIESIHYL-...GTTGHTL..KSGCKLTNAKPPKYSSKVVLSGEWNAVYRAFGSPFITNgmslldiiVKPVFFNAFVKCN-CGSESWSVGAWD.GYLSSCCGTPA.KKLCV..-VPGNVVPGDV-..........................IITSTSAGC...GVKY...YAGLVVKHI......TNITGVSLW D9J203.1/112-312 -VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE-...........IVIDGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL-...MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNggnlnecfAKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGTPG.KVIGV..-SIGDASVGEA-..........................VITSKGCGT...GTKF...YAGAVLKYV......GDAEGVSVW D9J202.1/112-312 -VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE-...........IVIDGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL-...MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNggnlnecfAKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGTPG.KVIGV..-SIGDASVGEA-..........................VITSKGCGT...GTKF...YAGAVLKYV......GDAEGVSVW A0A172B3C8.1/112-312 -TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD-...........IVIDGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL-...QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNgdnlhgcfTKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGLPG.KVIGV..-SLGNAAVGEA-..........................VVTSKGCGN...GTKF...YANAVLKHV......GDADDVSIW A0A172B201.1/112-312 -TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD-...........IVIDGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL-...QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNgdnlhgcfTKLNFIVANVKCK-CGGESSGVGDWT.GFKSACCGLPG.KVIGV..-SLGNAAVGEA-..........................VVTSKGCGN...GTKF...YANAVLKHV......GDADDVSIW A0A088DIE1.1/179-416 --RYVDNYYCTGDGKPLP-----CIVT...LLEKAGHAnkplddamdylRGLNRMGQPCRdhdhervWEVERD.NAPYPEQSLFSISAIKTL-...GEIPHCVfaPDCAVKVMKPRKVKRGADGFMTKLRRVYNINGFDEV--........-KPMALCALHYCEDCGMEMWCHSNFE.EAYCPCGKIYT.NTPCT.lTSAGYVVEGSVVampcdacksdsd.hsngtfydsckylAEDKAEPGN...RENFv.yFGGCCFAYV......GCRNGNAIW A0A0U1WHG0.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...LLARAGKSmctlp.eqldfIESKRGVYCCReheheiaWYTERS.DKSYEHQTPFEVKIAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKNTEGFMGRIRSVYQVATPNECND........---MHLSVFMKCNHCDEASWQTCDFL.KATCEYCGTE-.NPVSEgpTTCGYLPTNAVVkmpcpacqnkevgpehsvadyhnhssIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW R9QTB2.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKSmctls.eqldyIESKRGVYCCReheheivWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQECND........---MHLSTLMKCNHCDEVSWQTCDFI.KATCEQCGTE-.NPVCEgpTTCGYLPTNAVVkmpcpacqdpevgpehsvadyhnhsnIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW D2DJW3.1/183-423 -TRYVDNNLCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGIE-.NLITEgpTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW Q5DIC6.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdhehgiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW B8Q8T6.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW Q692E5.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW P0C6U8.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW D2DJW2.1/183-423 -TRYVDNNLCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGIE-.NLITEgpTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW Q5DIC7.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdhehgiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW B8Q8T5.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW P0C6X7.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW Q692E6.1/183-423 -TRYVDNNFCGPDGYPLD-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCRdheheiaWFTERS.DKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEHCGTEN.LVIEG.pTTCGYLPTNAVVkmpcpacqdpeigpehsvadyhnhsnIETRLRKGG...RTRC...FGGCVFAYV......GCYNKRAYW P0C6F8.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCReheheivWFTERS.EKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQECND........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTE-.NLVCEgpTTCGYLPTNAVVkmpcpacqdpevgpehsvadyhnhsnIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW P0C6W2.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...FLARAGKSmctls.eqldyIESKRGVYCCReheheivWFTERS.EKSYEHQTPFEIKSAKKFDtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQECND........---MHLSTLMKCNHCDEVSWQTCDFL.KATCEQCGTE-.NLVCEgpTTCGYLPTNAVVkmpcpacqdpevgpehsvadyhnhsnIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW A0A0K1Z0N1.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKG...LLARAGKSmctls.eqldfIESKRGVYCCReheheiaWYTERS.DKSYEHQTPFDIKSAKKFDtfkEECPKFVfpLNSTVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCSHCDEVSWQTCDFL.KATCEHCGTEN.LVVEG.pTTCGYLPINAVVkmpcpacqnkevgpehsvadyhnysnIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW A0A0K1YZY7.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKG...LLARAGKSmctls.eqldfIESKRGVYCCReheheiaWYTERS.DKSYEHQTPFDIKSAKKFDtfkEECPKFVfpLNSTVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN........---MHLSTLMKCSHCDEVSWQTCDFL.KATCEHCGTEN.LVVEG.pTTCGYLPINAVVkmpcpacqnkevgpehsvadyhnysnIETRLRKGG...RTKC...FGGCVFSYV......GCYNKRAYW A3EXI9.1/192-395 -VKPVQDLLGDIRPDFTLEELTLCLSD...YRTDDG--...........YDLLGGYVKVA.......VKVVRK.PVPVVKQTIFTVQGVIEQCvegYYYPFP-..PMSAVKHTKPRSDKPLGKTVDSIMLSLYGTSG------........YNPATPVVRLRCSHCDFYGWVPLKDMgTVSCSCSAVHQlTSSCIdaESAGAIKPGCVM..........................LLDKSPGMRvipGNRTyvaFGGAIWSPI......GKVGDVTVW E0XIZ2.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKSsapla.eqldfLESKRGVYCCReheheiaWYTERS.DKSYELQTPFDITNAKKFDsfkGECPKFVfpLNSTVKVLQPRVEKKKTEGFLGRIRTVYQVASPGEC--........-NSMHLSTYMNCNHCGEKSWQTCDFL.TATCEMCGNQ-.NTVEEgpTTCGYVPSNAVVkmvcpacqnpeigpdhsvadyhnnskIETRLRKGG...RIKS...FGGCVFSYV......GCYNKRAFW P0DTC1.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKAsctls.eqldfIDTKRGVYCCReheheiaWYTERS.EKSYELQTPFEIKLAKKFDtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQ........---MCLSTLMKCDHCGETSWQTGDFV.KATCEFCGTENlTKEGA..TTCGYLPQNAVVkiycpachnsevgpehslaeyhnesgLKTILRKGG...RTIA...FGGCVFSYV......GCHNKCAYW P0DTD1.1/183-423 -TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKAsctls.eqldfIDTKRGVYCCReheheiaWYTERS.EKSYELQTPFEIKLAKKFDtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQ........---MCLSTLMKCDHCGETSWQTGDFV.KATCEFCGTENlTKEGA..TTCGYLPQNAVVkiycpachnsevgpehslaeyhnesgLKTILRKGG...RTIA...FGGCVFSYV......GCHNKCAYW P0C6T6.1/192-395 -VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG--...........YDLPDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQLvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN------........YNPATPVARLKCSYCDYYGWTPLKDIgTVNCLCGAEFQlTSSCVdaESAGVIKPGCVM..........................LLDKSPGMRlipGNRTyvsFGGAIWSPI......GKVNGVTVW P0C6W5.1/192-395 -VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG--...........YDLPDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQLvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN------........YNPATPVARLKCSYCDYYGWTPLKDIgTVNCLCGAEFQlTSSCVdaESAGVIKPGCVM..........................LLDKSPGMRlipGNRTyvsFGGAIWSPI......GKVNGVTVW A0A1B3Q5W8.1/193-395 --APIKEVLGGKGAGMSLVELTKFLGK...YRTADG--...........YELPSGIVKVA.......VKVVRK.NLPVSKQSIFTVLGVTERVvdgFYYPYS-..TNSVVSYTKPRAGATVGNTVQSVMLSMYGTEA------........YNPVTPVVRLRCSSCDFYGWVPVKDLgCVTCSCAAVHQiTSSCIdaESAGLIKQGAVM..........................LVDRSPSMRvvpGNRLyvaFGGAIWSPI......GKVNGVQVW E0ZN59.1/192-395 -VKPVQDLLGDIKPDLTLEKLTLALSD...YRKDDG--...........YDLPGGFVKIA.......VTVIRK.PVAVVKQTIFTVQGVVEQHvegYYYPYA-..PLGVVKQTKPAAGGPIGKTVEAIMLSLYGTSG------........YKPATPVARLKCSYCDHFGWTPLKDMgTVVCLCGAEYQlTSSCVdaESAGLIKPGCVM..........................LLDKSPGMRvipGNRTyvaFGGAIWSPI......GKVNDVTVW A3EXI1.1/192-395 -VKPVLELLGGIKPDLTLEKLTLALSE...YRNSDG--...........YDLPGGFVRVA.......VSVIRK.PVPVVKQTIFTVQGVVEQHvegFYYPYS-..TMSVVKHTKPRSDKPLGKTVESIMLSLYGTSG------........YSPATPVVRLRCSYCDFYGWVPPRDMgTVVCSCGAEFQlTSACVdaESAGAIKPGCVM..........................LLDRSPGMRlipGNRIyvaFGGAIWSPI......GTVNGVSVW A0A096XNJ3.2/115-290 -PIYVDQYLCGPDGTPVKKG--LEFKD...YFMNGGDI...........YVEPGKTYVRV.......WDVERK.QDDL---TLDGILSIKYL-...SDKPHKL..RDGAIQGVADAVSE-----LN-------DTN-------........QMVRFIHAFVSCP-CGKSAFTVGSWM.GFATVCCGKIVkTPMCV..KFSGEAGSIFAL..........................PVGSRGFSA..nGKRS...YAGAEFQFC......CELSGVEIW A0A240FW17.1/112-262 -VVYVDNYLCGNNGKPVVPKDKWKILS...K---GQQG...........LLADNVYYKVV.......WDVKRD.DVPYEKQNMSSIVSIRYL-...IDIPHFL..ADGAVREKKRPPQDYTTML----------VKGFPFLMA........YDWKFVNHAVKCGKCDNHVVEAGAFE.SVITSCCRDEI.VHQGV..---VTAKAGEL-..........................---------...----...---------......--------- A0A1X9JQL5.1/116-197 --IFVDQYLCGADGTPVK--RDVEFKN...YFTDGDT-...........YVEPGKTYKLV.......WNVERK.PGDL---TLSGILSIKYL-...SDKPHKL..RDGVVQEVADAVS-------------------------........--------------------------.-----------.-----..------------..........................---------...----...---------......--------- A0A1X9JQL5.1/207-287 ---------------------------...--------...........-----------.......------.-------------------...-------..--------------------------------------........---RFIHGFVSCP-CGKSAFTVGGWN.GFATVCCGVTVkSPICV..KFSGKA--GSIF.........................aLPLGSRVFG...TKRI...YAGAEFQYC......CDLSGVEIW //