Summary: PMP-22/EMP/MP20/Claudin family
PMP-22/EMP/MP20/Claudin family Provide feedback
No Pfam abstract.
Internal database links
|Similarity to PfamA using HHSearch:||SUR7 Clc-like L_HGMIC_fpl Claudin_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004031Several vertebrate small integral membrane glycoproteins are evolutionary related [PUBMED:7499407, PUBMED:7499420, PUBMED:8996089], including eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1), which is also known as tumor-associated membrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2), which is also known as XMP; epithelial membrane protein-3 (EMP-3), also known as YMP; and peripheral myelin protein 22 (PMP-22), which is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size, and contain four transmembrane segments. PMP-22, EMP-1, -2 and -3 are highly similar, while MP20 is more distantly related. This family also includes the claudins, which are components of tight junctions.
|Cellular component||membrane (GO:0016020)|
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Curation and family details
|Seed source:||Pfam-B_1393 (release 2.1)|
|Number in seed:||13|
|Number in full:||2113|
|Average length of the domain:||165.70 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||76.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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