Summary: Phosphorylase superfamily
Phosphorylase superfamily Provide feedback
Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)
Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE; , Structure 1997;5:1373-1383.: The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology. PUBMED:9351810 EPMC:9351810
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000845
Phosphorylases in this entry include:
- Purine nucleoside phosphorylase (EC) (PNP) from most bacteria (gene deoD), which catalyses the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [PUBMED:8534998].
- Uridine phosphorylase (EC) (UdRPase) from bacteria (gene udp) and mammals, which catalyses the cleavage of uridine into uracil and ribose-1-phosphate, the products of the reaction are used either as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis [PUBMED:7744869].
- 5'-methylthioadenosine phosphorylase (EC) (MTA phosphorylase) from Sulfolobus solfataricus [PUBMED:7929153].
- Purine nucleoside phosphorylase (EC) (PNP) from mammals as well as from some bacteria (gene deoD). This enzyme catalyzes the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [PUBMED:2104852].
- 5'-methylthioadenosine phosphorylase (EC) (MTA phosphorylase) from eukaryotes [PUBMED:8687427].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||catalytic activity (GO:0003824)|
|Biological process||nucleoside metabolic process (GO:0009116)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_1190 (release 3.0)|
|Author:||Finn RD, Bateman A|
|Number in seed:||159|
|Number in full:||15802|
|Average length of the domain:||227.10 aa|
|Average identity of full alignment:||18 %|
|Average coverage of the sequence by the domain:||76.95 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PNP_UDP_1 domain has been found. There are 837 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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