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89  structures 1977  species 0  interactions 37325  sequences 733  architectures

Family: PP2C (PF00481)

Summary: Protein phosphatase 2C

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Protein phosphatase 2C Provide feedback

Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.

Literature references

  1. Das AK, Helps NR, Cohen PT, Barford D; , EMBO J 1996;15:6798-6809.: Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. PUBMED:9003755 EPMC:9003755


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001932

Protein phosphatases remove phosphate groups from various proteins that are the key components of a number of signalling pathways in eukaryotes and prokaryotes. Protein phosphatases that dephosphorylate Ser and Thr residues are classified into the phosphoprotein (PPP) and the protein phosphatase Mg2- or Mn2-dependent (PPM) families. The core structure of PPMs is the 300-residue PPM-type phosphatase domain that catalyses the dephosphorylation of phosphoserine- and phosphothreonine-containing protein. The PPM-type phosphatase domain is found as a module in diverse structural contexts and is modulated by targeting and regulatory subunits [ PUBMED:9003755 , PUBMED:9869399 , PUBMED:22115775 , PUBMED:22668558 ].

Some proteins known to contain a PPM-type phosphatase domain are listed below:

  • Bacillus subtilis stage II sporulation protein E (SpoIIE), controls the sporulation by dephosphorylating an anti-transcription factor SpoIIAA, reversing the actions of the SpoIIAB protein kinase in a process that is governed by the ADP/ATP ratio [levdikov].
  • Mycobacterium tuberculosis PP2C-family Ser/Thr phosphatase (PstP).
  • Eucaryotic PP2C, a negative regulator of protein kinase cascades that are activated as a result of stress.
  • Yeast adenyl cyclase, plays essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, cAMP.
  • Mammalian mitochondrial pyruvate dehydrogenase phosphatase 1 (PDP1).
  • Plant kinase-associated protein phosphatase (KAPP), regulates receptor-like kinase (RLK) signalling pathways.
  • Plant absissic acid-insenstive 1 and 2 (ABI1 and ABI2), play a key absissic acid (ABA) signal transduction.

The PP2C-type phosphatase domain consists of 10 segments of beta-strands and 5 segments of alpha-helix and comprises a pair of detached subdomains. The first is a small beta-sandwich with strand beta1 packed against strands beta2 and beta3; the second is a larger beta-sandwich in which a four-stranded beta-sheet packs against a three-stranded beta-sheet with flanking alpha-helices [ PUBMED:9003755 , PUBMED:22115775 ].

This entry represents a conserved region found in the N-terminal part that contains a perfectly conserved tripeptide.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan PP2C (CL0238), which has the following description:

This clan includes the PP2C family of phosphatases as well as the SpoIIE family. This suggests SpoIIE proteins may also be phosphatases.

The clan contains the following 3 members:

PP2C PP2C_2 SpoIIE

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(28)
Full
(37325)
Representative proteomes UniProt
(71740)
RP15
(6545)
RP35
(18305)
RP55
(30653)
RP75
(40520)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(28)
Full
(37325)
Representative proteomes UniProt
(71740)
RP15
(6545)
RP35
(18305)
RP55
(30653)
RP75
(40520)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(28)
Full
(37325)
Representative proteomes UniProt
(71740)
RP15
(6545)
RP35
(18305)
RP55
(30653)
RP75
(40520)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A , Finn RD
Number in seed: 28
Number in full: 37325
Average length of the domain: 220.10 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 47.95 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.3 20.3
Trusted cut-off 20.3 20.3
Noise cut-off 20.2 20.2
Model length: 258
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PP2C domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A060D932 View 3D Structure Click here
A0A075T3H0 View 3D Structure Click here
A0A075T8J6 View 3D Structure Click here
A0A075T8K1 View 3D Structure Click here
A0A096T5F5 View 3D Structure Click here
A0A0B4J374 View 3D Structure Click here
A0A0N7KS54 View 3D Structure Click here
A0A0P0VL93 View 3D Structure Click here
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A0A0P0VL96 View 3D Structure Click here
A0A0P0VLF3 View 3D Structure Click here
A0A0P0VYA4 View 3D Structure Click here
A0A0P0XTZ8 View 3D Structure Click here
A0A0P0Y6C4 View 3D Structure Click here
A0A0R0EDI1 View 3D Structure Click here
A0A0R0EP66 View 3D Structure Click here
A0A0R0EP66 View 3D Structure Click here
A0A0R0FIU5 View 3D Structure Click here
A0A0R0FSW9 View 3D Structure Click here
A0A0R0GC01 View 3D Structure Click here
A0A0R0GC70 View 3D Structure Click here
A0A0R0H9F2 View 3D Structure Click here
A0A0R0H9F2 View 3D Structure Click here
A0A0R0HLG9 View 3D Structure Click here
A0A0R0HTU9 View 3D Structure Click here
A0A0R0HVD0 View 3D Structure Click here
A0A0R0HVD0 View 3D Structure Click here
A0A0R0HWP3 View 3D Structure Click here
A0A0R0HWP3 View 3D Structure Click here
A0A0R0IAH3 View 3D Structure Click here
A0A0R0IIR5 View 3D Structure Click here
A0A0R0IXS6 View 3D Structure Click here
A0A0R0IY93 View 3D Structure Click here
A0A0R0J5S5 View 3D Structure Click here
A0A0R0J7N3 View 3D Structure Click here
A0A0R0JU00 View 3D Structure Click here
A0A0R0K895 View 3D Structure Click here
A0A0R0K895 View 3D Structure Click here
A0A0R0KB30 View 3D Structure Click here
A0A0R0KBR6 View 3D Structure Click here
A0A0R0KDL4 View 3D Structure Click here
A0A0R0KEP1 View 3D Structure Click here
A0A0R0KJZ5 View 3D Structure Click here
A0A0R0KP40 View 3D Structure Click here
A0A0R0KTE8 View 3D Structure Click here
A0A0R0KWZ4 View 3D Structure Click here
A0A0R0KYI8 View 3D Structure Click here
A0A0R0LBA6 View 3D Structure Click here
A0A0R0LFV7 View 3D Structure Click here
A0A0R4J346 View 3D Structure Click here
A0A0R4J3G6 View 3D Structure Click here
A0A0R4J3G6 View 3D Structure Click here
A0A0R4J5P1 View 3D Structure Click here
A0A0U1RRU5 View 3D Structure Click here
A0A1D6DVE9 View 3D Structure Click here
A0A1D6DW03 View 3D Structure Click here
A0A1D6E6A1 View 3D Structure Click here
A0A1D6E9K7 View 3D Structure Click here
A0A1D6EBP3 View 3D Structure Click here
A0A1D6EED5 View 3D Structure Click here
A0A1D6EEY0 View 3D Structure Click here
A0A1D6EEY0 View 3D Structure Click here
A0A1D6EEY0 View 3D Structure Click here
A0A1D6EI98 View 3D Structure Click here
A0A1D6EL89 View 3D Structure Click here
A0A1D6EME9 View 3D Structure Click here
A0A1D6ENM0 View 3D Structure Click here
A0A1D6EX05 View 3D Structure Click here
A0A1D6F1D0 View 3D Structure Click here
A0A1D6F1W3 View 3D Structure Click here
A0A1D6F2H9 View 3D Structure Click here
A0A1D6F2L1 View 3D Structure Click here
A0A1D6F4T5 View 3D Structure Click here
A0A1D6F552 View 3D Structure Click here
A0A1D6F746 View 3D Structure Click here
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A0A1D6FD33 View 3D Structure Click here
A0A1D6FDU2 View 3D Structure Click here
A0A1D6FHN3 View 3D Structure Click here
A0A1D6FHQ6 View 3D Structure Click here
A0A1D6FIA6 View 3D Structure Click here
A0A1D6FJ42 View 3D Structure Click here
A0A1D6FKT5 View 3D Structure Click here
A0A1D6FL99 View 3D Structure Click here
A0A1D6FUP5 View 3D Structure Click here
A0A1D6FUV6 View 3D Structure Click here
A0A1D6FVP5 View 3D Structure Click here
A0A1D6FXQ1 View 3D Structure Click here
A0A1D6FXQ1 View 3D Structure Click here
A0A1D6FXR7 View 3D Structure Click here
A0A1D6G2U9 View 3D Structure Click here
A0A1D6GE50 View 3D Structure Click here
A0A1D6GK65 View 3D Structure Click here
A0A1D6H2J0 View 3D Structure Click here
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A0A1D6HGI0 View 3D Structure Click here
A0A1D6HNI8 View 3D Structure Click here
A0A1D6HSJ7 View 3D Structure Click here
A0A1D6HTC4 View 3D Structure Click here
A0A1D6HVS0 View 3D Structure Click here
A0A1D6HW02 View 3D Structure Click here
A0A1D6HXF5 View 3D Structure Click here
A0A1D6HY76 View 3D Structure Click here
A0A1D6I0Z7 View 3D Structure Click here
A0A1D6I2M0 View 3D Structure Click here
A0A1D6IAL9 View 3D Structure Click here
A0A1D6IAL9 View 3D Structure Click here
A0A1D6IF37 View 3D Structure Click here
A0A1D6IK15 View 3D Structure Click here
A0A1D6ILB4 View 3D Structure Click here
A0A1D6IWM5 View 3D Structure Click here
A0A1D6IWS9 View 3D Structure Click here
A0A1D6IYT3 View 3D Structure Click here
A0A1D6J2A7 View 3D Structure Click here
A0A1D6J2A9 View 3D Structure Click here
A0A1D6J4S2 View 3D Structure Click here
A0A1D6J580 View 3D Structure Click here
A0A1D6JDD2 View 3D Structure Click here
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A0A1D6JLA5 View 3D Structure Click here
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A0A1D6JY58 View 3D Structure Click here
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A0A1D6KIB7 View 3D Structure Click here
A0A1D6KTI6 View 3D Structure Click here
A0A1D6KU98 View 3D Structure Click here
A0A1D6L1G0 View 3D Structure Click here
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A0A1D6L5J6 View 3D Structure Click here
A0A1D6L839 View 3D Structure Click here
A0A1D6L9Y0 View 3D Structure Click here
A0A1D6LCX5 View 3D Structure Click here
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A0A1D6LMV0 View 3D Structure Click here
A0A1D6LTC9 View 3D Structure Click here
A0A1D6M240 View 3D Structure Click here
A0A1D6MDW4 View 3D Structure Click here
A0A1D6ME32 View 3D Structure Click here
A0A1D6MTG2 View 3D Structure Click here
A0A1D6MTH5 View 3D Structure Click here
A0A1D6N1M4 View 3D Structure Click here
A0A1D6N7C4 View 3D Structure Click here
A0A1D6NKP3 View 3D Structure Click here
A0A1D6NMW5 View 3D Structure Click here
A0A1D6NRQ9 View 3D Structure Click here
A0A1D6P0A4 View 3D Structure Click here
A0A1D6P319 View 3D Structure Click here
A0A1D6P4V8 View 3D Structure Click here
A0A1D6P537 View 3D Structure Click here
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A0A1D6P550 View 3D Structure Click here
A0A1D6P550 View 3D Structure Click here
A0A1D6P7P9 View 3D Structure Click here
A0A1D6P7Z3 View 3D Structure Click here
A0A1D6P994 View 3D Structure Click here
A0A1D6P994 View 3D Structure Click here
A0A1D6PCB8 View 3D Structure Click here
A0A1D6PCS3 View 3D Structure Click here
A0A1D6PJL5 View 3D Structure Click here
A0A1D6PRI5 View 3D Structure Click here
A0A1D6PVX1 View 3D Structure Click here
A0A1D6Q1K9 View 3D Structure Click here
A0A1D6QAR2 View 3D Structure Click here
A0A1D6QC07 View 3D Structure Click here
A0A1D6QNV1 View 3D Structure Click here
A0A1D6QQA4 View 3D Structure Click here
A0A1D8PEN6 View 3D Structure Click here
A0A1D8PR83 View 3D Structure Click here
A0A1D8PRZ8 View 3D Structure Click here
A0A1X7YHN5 View 3D Structure Click here
A0A2R8QDD8 View 3D Structure Click here
A0A2R8QH09 View 3D Structure Click here
A0A2R8RKS6 View 3D Structure Click here
A0A2R8RM47 View 3D Structure Click here
A0A2R8RQU4 View 3D Structure Click here
A0A2R8S086 View 3D Structure Click here
A0A2R8S086 View 3D Structure Click here
A0A368UGB6 View 3D Structure Click here
A0A368UI29 View 3D Structure Click here
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A0A368UK32 View 3D Structure Click here
A0JMP2 View 3D Structure Click here
A2BE49 View 3D Structure Click here
A3A8Q4 View 3D Structure Click here
A3A8Q4 View 3D Structure Click here
A3A8W2 View 3D Structure Click here
A3A8W6 View 3D Structure Click here
A3AZ89 View 3D Structure Click here
A3CCP9 View 3D Structure Click here
A3F4K2 View 3D Structure Click here
A3QMB1 View 3D Structure Click here
A3QMB1 View 3D Structure Click here
A4HSY2 View 3D Structure Click here
A4HW33 View 3D Structure Click here
A4HWB4 View 3D Structure Click here
A4I1B7 View 3D Structure Click here
A4I329 View 3D Structure Click here
A4I565 View 3D Structure Click here
A4I6Q8 View 3D Structure Click here
A4I7Y4 View 3D Structure Click here
A4IA25 View 3D Structure Click here
A4IA26 View 3D Structure Click here
A4ICL1 View 3D Structure Click here
A4ICT4 View 3D Structure Click here
A7MBY9 View 3D Structure Click here
A8MPX8 View 3D Structure Click here
A9JRU2 View 3D Structure Click here
B1WCA0 View 3D Structure Click here
B4F7V3 View 3D Structure Click here
B4F8M0 View 3D Structure Click here
B4F8R0 View 3D Structure Click here
B4F8Y6 View 3D Structure Click here
B4F936 View 3D Structure Click here
B4FBQ5 View 3D Structure Click here
B4FDN2 View 3D Structure Click here
B4FG43 View 3D Structure Click here
B4FMH3 View 3D Structure Click here
B4FP36 View 3D Structure Click here
B4FR17 View 3D Structure Click here
B4FRY4 View 3D Structure Click here
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B4FTA0 View 3D Structure Click here
B4FTI9 View 3D Structure Click here
B4FUZ1 View 3D Structure Click here
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B4FZ34 View 3D Structure Click here
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B6SY45 View 3D Structure Click here
B6TCQ4 View 3D Structure Click here
B7F9R3 View 3D Structure Click here
B7ZYA2 View 3D Structure Click here
B8A1V9 View 3D Structure Click here
C0H4F2 View 3D Structure Click here
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C0H4T6 View 3D Structure Click here
C0HEP1 View 3D Structure Click here
C0HHW8 View 3D Structure Click here
C0HIT8 View 3D Structure Click here
C0P454 View 3D Structure Click here
C0P4W6 View 3D Structure Click here
C0P7M7 View 3D Structure Click here
C0PEY1 View 3D Structure Click here
C0PGX1 View 3D Structure Click here
C0PLV7 View 3D Structure Click here
C4JAG1 View 3D Structure Click here
C4JAK8 View 3D Structure Click here
D3ZP99 View 3D Structure Click here
D3ZZT7 View 3D Structure Click here
D4A254 View 3D Structure Click here
D4A7X5 View 3D Structure Click here
E7EY20 View 3D Structure Click here
E7FAZ1 View 3D Structure Click here
F1LNI5 View 3D Structure Click here
F1LNI5 View 3D Structure Click here
F1QD96 View 3D Structure Click here
F1QJE5 View 3D Structure Click here
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F1QKC2 View 3D Structure Click here
F1QWM5 View 3D Structure Click here
F1R0V7 View 3D Structure Click here
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F4IG99 View 3D Structure Click here
G5EDI3 View 3D Structure Click here
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I1J9C1 View 3D Structure Click here
I1J9K2 View 3D Structure Click here
I1JBC4 View 3D Structure Click here
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I1JHE6 View 3D Structure Click here
I1JI15 View 3D Structure Click here
I1JPH1 View 3D Structure Click here
I1JQY9 View 3D Structure Click here
I1JQY9 View 3D Structure Click here
I1JR75 View 3D Structure Click here
I1K2K9 View 3D Structure Click here
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I1K7B1 View 3D Structure Click here
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I1KAU7 View 3D Structure Click here
I1KF44 View 3D Structure Click here
I1KJY3 View 3D Structure Click here
I1KMJ5 View 3D Structure Click here
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I1KN61 View 3D Structure Click here
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I1L0M5 View 3D Structure Click here
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I1L484 View 3D Structure Click here
I1L698 View 3D Structure Click here
I1L765 View 3D Structure Click here
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I1LB72 View 3D Structure Click here
I1LB78 View 3D Structure Click here
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I1LF55 View 3D Structure Click here
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I1LG94 View 3D Structure Click here
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I1LS61 View 3D Structure Click here
I1LX67 View 3D Structure Click here
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I1M359 View 3D Structure Click here
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I1M834 View 3D Structure Click here
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I1M9D7 View 3D Structure Click here
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I1MBC7 View 3D Structure Click here
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I1MHZ3 View 3D Structure Click here
I1MN10 View 3D Structure Click here
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I1MRS0 View 3D Structure Click here
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I1MSE4 View 3D Structure Click here
I1MX28 View 3D Structure Click here
I1MXD3 View 3D Structure Click here
I1MXP8 View 3D Structure Click here
I1MZY0 View 3D Structure Click here
I1N2G6 View 3D Structure Click here
I1N335 View 3D Structure Click here
I1N3Z6 View 3D Structure Click here
I1N4Z5 View 3D Structure Click here
I1N738 View 3D Structure Click here
I1N985 View 3D Structure Click here
I1NA36 View 3D Structure Click here
I1NBT4 View 3D Structure Click here
I1NBU1 View 3D Structure Click here
I1NF89 View 3D Structure Click here
I1NFM6 View 3D Structure Click here
I1NG07 View 3D Structure Click here
I1NJ38 View 3D Structure Click here
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I1NJE2 View 3D Structure Click here
K7K436 View 3D Structure Click here
K7K5B2 View 3D Structure Click here
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K7KB73 View 3D Structure Click here
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